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Aphthous Stomatitis5

Aphthous stomatitis (canker sores) is commonly observed and is mediated by the immune system.  Lesions usually appear as painful, tiny, discrete, or grouped papules and vesicles.  These lesions are small in diameter with round, shallow ulcerations predominantly seen over the labial and buccal mucosa.  The reactions heal without scarring in 10-14 days, however, recurrence is common.  Drugs with potential to cause aphthous stomatitis are shown in Table 3.

Table 3. Drugs with potential to cause aphthous stomatitis
Azathiopurine Losartan
Captopril NSAIDs
Cyclosporine Olanzapine
Fluoxetine Penicillamine
Gold compounds Sertraline
Indinavir Sulfonamides
Interferons
 

Burning Mouth Syndrome

This syndrome may occur due to psychogenic factors, hormonal withdrawal, folate, iron, pyridoxine deficiency, or hypersensitivity reactions to the materials utilized in dental prostheses.1  There is a case report of burning mouth syndrome after taking clonazepam.6  Cases of “scalded mouth” caused by captopril, lisinopril, and enalapril have been described.7-9  The mechanism of ACE-inhibitor “scalded mouth” is uncertain, but it may be a subclinical manifestation of lichen planus.

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Page 4 of 22
Citation Number:
Vol. 4, No. 1, Page 013