

Aphthous Stomatitis5
Aphthous stomatitis (canker sores) is commonly observed and is mediated by the immune system. Lesions usually appear as painful, tiny, discrete, or grouped papules and vesicles. These lesions are small in diameter with round, shallow ulcerations predominantly seen over the labial and buccal mucosa. The reactions heal without scarring in 10-14 days, however, recurrence is common. Drugs with potential to cause aphthous stomatitis are shown in Table 3.
| Table 3. Drugs with potential to cause aphthous stomatitis | |
| Azathiopurine | Losartan |
| Captopril | NSAIDs |
| Cyclosporine | Olanzapine |
| Fluoxetine | Penicillamine |
| Gold compounds | Sertraline |
| Indinavir | Sulfonamides |
| Interferons |
|
Burning Mouth Syndrome
This syndrome may occur
due to psychogenic factors, hormonal withdrawal, folate, iron, pyridoxine deficiency,
or hypersensitivity reactions to the materials utilized in dental prostheses.1
There is a case report of burning mouth syndrome after taking clonazepam.6
Cases of “scalded mouth” caused by captopril, lisinopril, and enalapril
have been described.7-9
The mechanism of ACE-inhibitor “scalded mouth” is uncertain, but
it may be a subclinical manifestation of lichen planus.