

Glossitis5
Glossitis is inflammation of the tongue that is characterized by swelling and intense pain that may be referred to the ear area. Salivation, fever, and enlarged regional lymph nodes may develop during an infectious disease or after a burn, bile, or other injury. Drugs that have potential to cause glossitis are shown in Table 4.
| Table 4. Drugs that have potential to cause glossitis | ||
| Atrovastatin | Etidronate | Penicillamine |
| Benzodiazepines | Fluoxetine | Penicillins |
| Bleomycin | Fluvoxamine | Rivastigmine |
| Captopril | Gabapentin | Serteraline |
| Carbamazepine | Gold compounds | Sildenafil |
| Cephalosporines | Imipenem/cilastatin | Sulfonamides |
| Chloramphenicol | Lansoprazole | Tacrine |
| Chlorhexidine | Mefenamic acid | Tetracyclines |
| Clarithromycin | Mercaptopurine | Triamterene |
| Clomipramine | Methotrexate | Tricyclic antidepressants |
| Cyclosporine | Metronidazole | Trihexyphenidyl |
| Doxepin | NSAIDs | Venlafaxine |
| Enalapril | Olanzapine | |
Erythema Multiforme (Stevens–Johnson Syndrome)1,5,10-12
Erythema muultiforme, which when severe is termed Stevens–Johnson Syndrome, is a mucocutaneous disorder characterized by various clinical types of lesions. Young male adults are predominantly affected. The lips are swollen, crusted, and bleeding. Widespread erythema can be seen within the mouth. The oral lesions disappear within 14 days of drug withdrawal. Only 4% of erythema multiforme reactions are caused by drugs, however, 80% of cases occur in Stevens–Johnson Syndrome. Drugs with potential to cause erythema multiforme are shown in Table 5.
| Table 5. Drugs with potential to cause erythema multiforme | ||
| Allopurinol | Ginseng | Penicillins |
| Barbiturates | Gold compounds | Phenothiazines |
| Carbamazepine | Iodine–containing mouth washes | Phenytoin |
| Chlorpropamide | Sulphonamides | Rifampicin |
| Clindamycin | Minoxidil | Tetracyclines |
| Combination of antimalarial drugs (chloroquine and sulfadoxine-pyrimethamine) | NSAIDs | Tolbutamide |
| Estrogens/Progestins | Penicillamine | Verapamil |
| Ethambutol | ||