Introduction

The past months have been characterized by rapid innovation in vital bleaching, especially with the advent of new in-office options for immediate care and the emerging popularity of the direct-to-consumer systems.  Such is the case with the recently developed whitening strip – a novel bleaching system that uses a flexible polyethylene strip to deliver a hydrogen peroxide bleaching gel to the anterior dentition.¹  This “trayless” delivery system is reported to offer advantages with respect to overall peroxide dose, contact time, and ease-of-use compared to other delivery systems.²

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Evidence of the safe and efficacious use of the strip bleaching systems has been established in a series of randomized clinical trials relative to various marketed or experimental controls in studies involving different populations and time points.^3-16  Use of whitening strips was well-tolerated, with transient tooth sensitivity and minor oral irritation representing the most prominent side effects.  The majority of events were mild in severity.  In one integrated summary of 13 whitening strip clinical studies, only 1% of subjects who used strips discontinued treatment early because of tooth sensitivity or oral irritation.³

In composite, the published clinical data on whitening strips represents one of the most comprehensive bodies of research on vital bleaching in the literature.  The trials were conducted at various sites by different investigators using several study designs and measurement methods.  This extensive clinical research program evaluated whitening strip effectiveness and safety across a broad range of populations, formulations, and usage conditions.  Since the mid-year 2000 introduction of Crest_® Whitestrips^®, there are already over 80 abstracts and publications on the clinical and preclinical effectiveness and safety of strip-based vital bleaching.

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Citation Number: Vol. 5, No. 1, Page 002