The aim of the present study is to observe the changes in bone turnover markers, deoxypyridinoline (Dpd), osteocalcin, n-telopeptide (NTx), and bone alkaline phosphatase (balp) during the experimental orthodontic intrusion of maxillary premolar teeth.  The study population required fixed appliance therapy involving the extraction of the maxillary first premolar teeth.  Gingival crevicular fluid (GCF) samples were collected from each patient by using paper strips before the appliances were fitted and 1, 24, and 168 hours after the activation of appliances.  After the second activation on the 21^st, 22^nd, and 28^th days of the study, samples were collected.  Enzyme-Linked Immunosorbent Assay (ELISA) tests were performed following manufacturer’s recommendations.  The results of the study indicate Dpd, osteocalcin, and balp values decrease with force application.  Among the tested parameters only Dpd values showed statistically significant changes through time.  One, 7, 22, and 28 day results show a significant amount of decrease when compared to 0 days.  The extra decrease on the 22^nd day (the day after the second activation) is also significantly lower.  NTx crosslink values could not be detected in the experimental samples.

Keywords:  Intrusion, osteocalcin, bone alkaline phosphatase, deoxypyridinoline, n-telopeptide

Citation:  Isik F, Sayinsu K, Arun T, Ünlüçerçi Y.  Bone Marker Levels in Gingival Crevicular Fluid During Orthodontic Intrusive Tooth Movement: A Preliminary Study.  J Contemp Dent Pract 2005 May;(6)2:027-035.