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VOLUME 1 , ISSUE 4 ( Fall Issue, 1999 ) > List of Articles

RESEARCH ARTICLE

Anticalculus Effects of a Novel, Dual-Phase Polypyrophosphate Dentifrice: Chemical Basis, Mechanism, and Clinical Response

Donald J. White, Robert W. Gerlach

Citation Information : White DJ, Gerlach RW. Anticalculus Effects of a Novel, Dual-Phase Polypyrophosphate Dentifrice: Chemical Basis, Mechanism, and Clinical Response. J Contemp Dent Pract 1999; 1 (4):59-70.

DOI: 10.5005/jcdp-1-4-59

License: CC BY-NC 3.0

Published Online: 01-11-2004

Copyright Statement:  Copyright © 2000; The Author(s).


Abstract

A primary patient motivation for oral hygiene is effective cleaning. Dentifrice serves this function by including ingredients such as abrasives, surfactants, and specialized cleaning ingredients such as anticalculus agents. This introductory article aims to introduce professionals, educators, and researchers on the rationale behind the development of an improved cleaning dentifrice formulation, Crest® Multicare Advanced Cleaning. This new dentifrice is based upon the application of an improved tartar control/cleaning ingredient that is a polymeric adjunct of a pyrophosphate anion commonly applied in tartar control and stain control whitening dentifrices. The polypyrophosphate anion, also referred to as sodium hexametaphosphate, produces superior activity and substantivity on oral surfaces as compared to both pyrophosphate and some other commonly used dental cleaning ingredients and cleaning/conditioning adjuncts. The increased activity and substantivity translate into significant improvements in the prevention of dental stains and supragingival calculus and in the non-abrasive removal of dental stains.

This article describes the structure of polypyrophosphate as compared to the parent pyrophosphate molecule, the rationale for its improved chemistry, and, in particular, its tartar control chemistry. In addition, the fundamental mechanisms of calculus formation and inhibition are reviewed. Lastly, a preliminary clinical study evaluating the improved efficacy of a polypyrophosphate dentifrice is described where the tartar control activity of the polypyrophosphate dentifrice is shown to be superior to that of a clinically established and marketed industry standard pyrophosphate dentifrice.


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  1. Dental calculus: recent insights into occurrence, formation, prevention, removal and oral health effects of suprangingival and subgingival deposits. Eur J Oral Sci 1997;105:508-522.
  2. Tartar control dentifrices: current status and future prospects. In:Embery G, Rolla G, editors. Clinical and Biological Aspects of Dentifrices. Oxford: Oxford University Press, 1992:277-291.
  3. The association between supragingival calculus deposits and the extent of gingival recession in a sample of Thai children and teenagers. J Clin Dent 1991;6-11.
  4. Influence of soluble pyrophosphate on calculus formation in adults. J Dent Res 1985;64:1159-1162.
  5. The effect of soluble pyrophosphates on dental calculus in adults. J Am Dent Assoc 1985;110:737-738.
  6. A gene for smooth running joints. Science 2000;289:226-227.
  7. Processes contributing to the formation of dental calculus. Biofouling 1991;4:209-218.
  8. Composition of supragingival calculus. J Dent Res 1967;46:114-119.
  9. Physical chemical aspects of dental calculus formation and inhibition: in vitro and in vivo. In: ten Cate J, editor. Recent Advances in the Study of Dental Calculus. 1989:175-188.
  10. Dentifrice effects on uptake and retention of pyrophosphate in plaque. J Dent Res 1989;68:421 Abstract.
  11. Calculus inhibition agents: A review of recent clinical trials. Adv Dental Res 1995;9:410-418.
  12. Clinical efficacy of chemicals for calculus prevention. In: ten Cate J, editor. Recent Advances in the Study of Dental Calculus. Oxford: IRL Press, 1989:235-258.
  13. A review of calculus clinical efficacy studies. J Clin Dent 1992;4:71-81.
  14. In vivo calculus assessment, part I: a method and its examiner reproducibility. J Periodontol 1965;36:299-304.
  15. In vitro evaluations of pyrophosphate/copolymer/NaF as an anticalculus agent. Compend Supplt 1987;Suppl. 8: S242-250.
  16. Desorption of acquired enamel pellicle in vivo by pryophosphate. Scand J Dent Res 1990;98:(3)211-214.
  17. Effect of pyrophosphate on protein adsorption to hydroxyapatite in vitro and on pellicle formation in vivo. Scand J Dent Res 1988;96:517-522. Abstract.
  18. Dentifrice effects toward chemical stain control: An in vitro comparison. J Dent Res 2000;79:404 Abstract.
  19. Inventors. Dentifrice compositions containing polyphosphate and fluoride. 1999; (U.S. Patent #5,939,052).
  20. Novel model for evaluating anticalculus efficacy of tartar control dentifrices. J Dent Res 1999;78:497 Abstract.
  21. Comparative intraoral tolerance of polyphosphate and pyrophosphate antitartar dentifrices. J Dent Res 2000;79:429 Abstract.
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