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VOLUME 10 , ISSUE 4 ( July, 2009 ) > List of Articles


Stem Cells: Therapeutic Potential in Dentistry

Flávio Fernando Demarco, Dárvi de Almeida André, Fernanda Nedel, Isabel Oliveira de Oliveira, Mabel M. Cordeiro, Luciano Casagrande, Sandra Beatriz Chaves Tarquinio, Jacques Eduardo Nor

Citation Information : Demarco FF, de Almeida André D, Nedel F, de Oliveira IO, Cordeiro MM, Casagrande L, Tarquinio SB, Nor JE. Stem Cells: Therapeutic Potential in Dentistry. J Contemp Dent Pract 2009; 10 (4):90-96.

DOI: 10.5005/jcdp-10-4-90

License: CC BY-NC 3.0

Published Online: 01-04-2013

Copyright Statement:  Copyright © 2009; The Author(s).



The aim of this paper is to present a review and discussion of the current status of stem cell research with regard to tooth generation.


Stem cells have been isolated from the pulp tissue of both deciduous and permanent teeth as well as from the periodontal ligament. Dental pulp stem cells demonstrate the capacity to form a dentin pulp-like complex in immunocompromised mice. A tooth-like structure was successfully formed, using a heterogeneous mixture of dental enamel epithelium, pulp mesenchymal cells, and scaffolds.


The scientific community understands the need for more investigations to completely understand the conditions that would best favor the creation of a tooth substitute. Recent gains in the understanding of the molecular regulation of tooth morphogenesis, stem cell biology, and biotechnology offers the opportunity to realize this goal.

Clinical Significance

These findings, combined with the recent progress in stem cell research and tissue engineering, might allow the development of alternatives for current materials and therapies used to treat tooth tissue loss (e.g., enamel, dentin, pulp), reconstruct dentoalveolar and craniofacial bone defects, and eventually replace an entire tooth.


Nedel F, André DA, Oliveira IO, Cordeiro MM, Casagrande L, Tarquinio SBC, Nor JE, Demarco FF. Stem Cells: Therapeutic Potential in Dentistry. J Contemp Dent Pract 2009 July; (10)4:090-096.

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