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VOLUME 10 , ISSUE 5 ( September, 2009 ) > List of Articles

RESEARCH ARTICLE

Oral Squamous Cell Carcinoma: A Clinicopathological Study of 342 Thai Cases

Robert P. Langlais, Aree Jainkittivong, Somporn Swasdison, Malee Thangpisityotin

Citation Information : Langlais RP, Jainkittivong A, Swasdison S, Thangpisityotin M. Oral Squamous Cell Carcinoma: A Clinicopathological Study of 342 Thai Cases. J Contemp Dent Pract 2009; 10 (5):33-41.

DOI: 10.5005/jcdp-10-5-33

License: CC BY-NC 3.0

Published Online: 01-09-2009

Copyright Statement:  Copyright © 2009; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

To conduct a clinicopathological review of oral squamous cell carcinoma (SCC) and to analyze it with respect to gender, age at diagnosis, clinical presentation, lesion location, and histological grading.

Methods and Materials

Information on the clinicopathological characteristics of SCC was obtained from pathology reports of 342 cases.

Results

The male to female ratio was 1:1 and the incidence increased with age. Among the patients 4.7% were younger than 40 years and males were predominant in this subgroup. The alveolar ridge and gingiva were the most commonly affected sites (50%). The majority of the SCC cases presented as ulcers or masses. Swelling and/or pain were the first signs and/ or symptoms in most patients (52.6%). The age at diagnosis in relation to the site of occurrence varied. Conventional SCC was the most common subtype (88%). Well-differentiated SCC was the most common histological grading (78.6%).

Conclusion

In the present study, the incidence of SCC was age-related and showed equal gender distribution.

Clinical Significance

Routine examination of the oral cavity by dental practitioners and other health care providers aids in the early detection of premalignant and malignant oral disease. Dentists can play a significant role in disseminating information regarding oral cancer.

Citation

Jainkittivong A, Swasdison S, Thangpisityotin M, Lnaglais RP. Oral Squamous Cell Carcinoma: A Clinicopathological study of 342 Thai Cases. J Contemp Dent Pract [Internet]. 2009 Sept; 10(5). Available from: http://www.thejcdp. com/journal/view/oralsquamous-cell-carcinoma-aclinicopathological- study-of-342-thai-cases.


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  1. Oral cancer and precancerous lesions. CA Cancer J Clin. 2002; 52(4):195-215.
  2. Squamous cell carcinoma of the oral tissues: a comprehensive review for oral healthcare providers. J Contemp Dent Pract. 2005; 6(4): 1-16.
  3. Histologic subtypes of oral squamous cell carcinoma: prognostic relevance. J Can Dent Assoc. 2007; 73(4):339-44.
  4. Primary malignant neoplasms of orofacial origin: a retrospective review of 256 cases in a Nigerian tertiary hospital. Int J Oral Maxillofac Surg. 2007; 36(5):403-8.
  5. Oral and pharyngeal cancer mortality rates in Mexico, 1979-2003. J Oral Pathol Med. 2008; 37(1):11-7.
  6. Mucosal condition of the oral cavity and sites of origin of squamous cell carcinoma. J Oral Maxillofac Surg. 1995; 53(2):144-7.
  7. Smoking, alcohol and oral cancer in south east Scotland: a 10-year experience. Br J Oral Maxillofac Surg. 1994; 32(3):146-52.
  8. Identification of risk factors for specific subsites within the oral and oropharyngeal region—a study of 647 cancer patients. Indian J Cancer. 2000; 37(2-3):114-22.
  9. Oral squamous cell carcinoma: a retrospective study of 740 cases in a Brazilian population. Braz Dent J. 2001; 12(1):57-61.
  10. Analysis of 587 cases of oral squamous cell carcinoma in northern Thailand with a focus on young people. Int J Oral Maxillofac Surg. 2004; 33(1):84-8.
  11. Clinico-pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age. J Oral Pathol Med. 2005; 34(3):129-33.
  12. Oral cavity and pharynxthroat cancer in the United States, 1973-2003. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 104(5):653-8.
  13. Squamous cell carcinoma of the gingiva. A case series analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995; 80(2):183-7.
  14. Oral squamous cell carcinoma in North-Eastern Hungary. I. Epidemiology. Fogorv Sz. 2006; 99(4):161-7.
  15. Squamous cell carcinoma of the oral cavity. A clinico-pathological study of 106 Nigerian cases. J Maxillofac Surg. 1986; 14(5):267-9.
  16. Oral squamous cell carcinoma: a review of 246 Nigerian cases. Afr J Med Med Sci. 1999; 28(3-4):141-4.
  17. Smoking, gender, and age as risk factors for site-specific intraoral squamous cell carcinoma. A case-series analysis. Cancer. 1994; 73(3):509-13.
  18. Squamous cell carcinoma of the oral cavity in patients younger than 40 years. Otolaryngol Head Neck Surg. 1997; 117(3 Pt 1):268-75.
  19. Intra-oral squamous cell carcinoma in Nigerians under 40 years of age: a clinicopathological review of eight cases. Afr J Med Med Sci. 2005; 34(1):99-102.
  20. Squamous cell carcinoma of the oral cavity, maxillary antrum and lip in a Zimbabwean population: a descriptive epidemiological study. Oral Oncol. 2006; 42(2):184-9.
  21. Tumours of the oral cavity and oropharynx. In: WHO classification of tumours. Pathology and genetics: Head and neck tumours. Lyon: IARC Press; 2005. p. 163-75.
  22. Basaloid squamous cell carcinoma of the oral mucosa: a new case and review of 45 cases in the literature. Oral Oncol. 2002; 38(1):120-4.
  23. Prognoses of oral basaloid squamous cell carcinoma and squamous cell carcinoma: a comparison. Arch Otolaryngol Head Neck Surg. 2004; 130(1):83-6.
  24. Squamous cell carcinoma of the upper aerodigestive tract: precursors and problematic variants. Mod Pathol. 2002; 15(3):229-54.
  25. Cancer incidence in Thailand, 1988-1991. Cancer Epidem Biomarkers Prev. 1995; 4(5):475-83.
  26. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer. 1993; 54(4):594-606.
  27. 2nd ed. Berlin: Springer-Verlag; 1997. p. 10-6.
  28. Oral cancer in Enugu, Nigeria, 1998-2003. Br J Oral Maxillofac Surg. 2007; 45(4):298-301.
  29. Cancer control in Thailand. Jpn J Clin Oncol. 2002;32(Suppl):S82-91.
  30. Risk factors for squamous cell carcinoma of the oral cavity in young people—a comprehensive literature review. Oral Oncol. 2001; 37(5):401-18.
  31. An analysis of risk factors for oral cancer in young people: a case-control study. Oral Oncol. 2004; 40(3):304-13.
  32. Malignant orofacial neoplasms in Lagos, Nigeria. East Afr Med J. 2006; 83(3):62-8.
  33. Clinical and histopathological analysis of oral squamous cell carcinoma in young people: a descriptive study in Brazilians. Br J Oral Maxillofac Surg. 2009; 47(2):95-8.
  34. Oral cavity cancers at a young age: analysis of patients, tumor and treatment characteristics in Chiang Mai University Hospital. Oral Oncol. 2006; 42(1):83-8.
  35. Demographic, aeitiological and survival differences of oral squamous cell carcinoma in the young and the old in Sri Lanka. Oral Oncol. 2006; 42(8):831-6.
  36. Oral squamous cell carcinoma: a clinicopathologic review of 233 cases in Lagos, Nigeria. J Oral Maxillofac Surg. 2008; 66(8):1595-9.
  37. Lip cancer in Northern Finland: changing incidence and clinical characteristics. J Oral Pathol Med. 2000; 29(7):299-302.
  38. Lip cancer experience in Mexico. An 11-year retrospective study. Oral Oncol. 2004; 40(10):992-9.
  39. Squamous cell carcinoma of the oral cavity: a case series analysis of clinical presentation and histological grading of 1,425 cases from Iraq. Clin Oral Investig. 2008; 12(1):15-8.
  40. Squamous cell carcinoma of the lips in a northern Greek population. Evaluation of prognostic factors on 5-year survival rate—I. Eur J Cancer B Oral Oncol. 1995;31B(5):333-9.
  41. Clinicopathological factors in early squamous cell carcinoma of the tongue and floor of the mouth, in Biscay (the Basque Country, Spain). Med Oral. 2001; 6(2):87-94.
  42. Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 106(5):685-95.
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