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VOLUME 11 , ISSUE 1 ( January, 2010 ) > List of Articles


Limited Benefit of Copaifera Oil on Gingivitis Progression in Humans

Sérgio Luís da Silva Pereira, Cristiane Simões Barros, Thiago Daher Yunes Salgado, Vicente Paulo Pereira Filho, Flávio Nogueira Costa

Citation Information : da Silva Pereira SL, Barros CS, Salgado TD, Filho VP, Costa FN. Limited Benefit of Copaifera Oil on Gingivitis Progression in Humans. J Contemp Dent Pract 2010; 11 (1):57-64.

DOI: 10.5005/jcdp-11-1-57

License: CC BY-NC 3.0

Published Online: 01-01-2010

Copyright Statement:  Copyright © 2010; Jaypee Brothers Medical Publishers (P) Ltd.



The aim of this in vivo study was to evaluate the antiplaque and antigingivitis effect of Copaifera sp (Cp).

Methods and Materials

Twenty-three subjects participated in a randomized controlled clinical trial using a 21-day, partial-mouth experimental model of gingivitis. A custom tooth shield was fabricated for each subject to prevent the brushing of the four experimental posterior teeth in the lower-left quadrant. The subjects were randomly assigned to either the control group (using a placebo gel) or the test group (using the test gel containing 10% Cp).


The clinical results showed statistically significant differences for plaque (PLI), bleeding (BI), and gingival (GI) indexes at days 0 and 21 in both groups (p<0.05). However, on day 21 there was no statistically significant difference between groups for all indexes (p>0.05).


The test gel containing 10% Cp did not prevent plaque formation and development of gingivitis.

Clinical Significance

Several medicinal herbs are used empirically by persons in the treatment and prevention of oral conditions. Research in this area must be encouraged to determine which herbal agents would be a useful addition to the current range of chemotherapeutic periodontal treatment options.


Pereira SLS, Barros CS, Salgado THY, Filho VPP, Costa FN. Limited Benefit of Copaifera Oil on Gingivitis Progression in Humans. J Contemp Dent Pract [Internet]. 2010 Jan; 11(1):057-064. Available from: http://www.thejcdp. com/journal/view/volume11-issue1-pereira.

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