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VOLUME 11 , ISSUE 1 ( January, 2010 ) > List of Articles

RESEARCH ARTICLE

Use of Ankaferd Blood Stopper™ as a Hemostatic Agent: A Clinical Experience

Timuçin Baykul, E. Guchan Alanoglu, Gulperi Kocer

Citation Information : Baykul T, Alanoglu EG, Kocer G. Use of Ankaferd Blood Stopper™ as a Hemostatic Agent: A Clinical Experience. J Contemp Dent Pract 2010; 11 (1):88-94.

DOI: 10.5005/jcdp-11-1-88

License: CC BY-NC 3.0

Published Online: 01-01-2010

Copyright Statement:  Copyright © 2010; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

To determine the efficacy of the topical application of Ankaferd Blood Stopper™ (ABS) on hemorrhagic diathesis following dental procedures under different conditions.

Background

Some patients have a tendency to bleed excessively after dental surgery for a variety of reasons, making oral surgical procedures more risky for these patients.1 Since hemorrhage can cause major morbidity and mortality, the identification of a novel, effective hemostatic agent could improve the management of excessive bleeding that occurs during dental procedures.

Case Descriptions

Four patients (3 females, 1 male) aged 28–45 with bleeding tendencies due to different presurgical conditions such as von Willebrand Disease, chronic liver failure, and mitral valve replacement presented for tooth extraction. Hematological consultations were obtained prior to surgical intervention and their international normalized (INR) ratio values were adjusted to less than 1.5; none received clotting factor replacement. All the extractions were performed under local anesthesia with and without epinephrine. In the presence of postsurgical bleeding, the efficacy of the ampule form of topical ABS was observed. Sex, age, anamnesis, von Willebrand Factor, activated partial thromboplastin time, factor VIII, and platelet counts of patients were recorded prior to the extractions.

Conclusions

ABS was found to be effective within 10 to 20 minutes in controlling bleeding in most of the patients after dental surgery. These observations suggest the use of ABS may be a beneficial hemostatic agent for use in patients with hemorrhagic diathesis following tooth extraction. Additional research is needed to clarify the role of this unique medicinal product in the surgical treatment of dental patients with bleeding tendency.

Clinical Significance

ABS has demonstrated potential for being an effective hemostatic agent for the treatment of excessive bleeding following dental surgery in four patients with hemorrhagic diathesis.

Citation

Baykul T, Alanoglu EG, Kocer G. Use of Ankaferd Blood Stopper™ as a Hemostatic Agent: A Clinical Experience. J Contemp Dent Pract [Internet]. 2010 Jan; 11(1):088-094. Available from: http://www.thejcdp.com/journal/ view/volume11-issue1-baykul.


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  1. Oral surgery in patients on anticoagulant therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002; 94(1):57-64.
  2. Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper. J Int Med Res. 2008; 36(1):163-70.
  3. Ultrastructural and morphological analyses of the in vitro and in vivo hemostatic effects of Ankaferd Blood Stopper. Clin Appl Thromb Hemost. (Forthcoming 2009). Epub 2009 Oct 14.
  4. In vivo hemostatic effect of the medicinal plant extract Ankaferd Blood Stopper in rats pretreated with warfarin. Clin Appl Thromb Hemost. 2009; 15(3):270-6.
  5. The efficacy of Ankaferd Blood Stopper in antithrombotic drug-induced primary and secondary hemostatic abnormalities of a rat-bleeding model. Blood Coagul Fibrinolysis. 2009; 20(3):185-90.
  6. Safety and efficacy of Ankaferd Blood Stopper in dental surgery and bleeding. Oral Surg Oral Med Oral Path Oral Radio Endod. (submitted).
  7. Bleeding disorders of importance in dental care and related patient management. J Can Dent Assoc. 2007; 73(1):77-83.
  8. Lack of a scientific basis for routine discontinuation of oral anticoagulation therapy before dental treatment. J Am Dent Assoc. 2003; 134(11):1492-7.
  9. Contemporary oral and maxillofacial surgery. 3rd ed. St. Louis, MO: C.V. Mosby; 1998. p. 270-4.
  10. Antimicrobial activity of plant extract Ankaferd Blood Stopper. Fitoterapia. 2009;80(1):48-50. Epub 2008 Oct 7.
  11. Ankaferd Blood Stopper as an effective adjunctive hemostatic agent for the management of life-threatening arterial bleeding of the digestive tract. Endoscopy. 2008;40 Suppl 2:E262. Epub 2008 Dec 17.
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