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VOLUME 11 , ISSUE 2 ( March, 2010 ) > List of Articles

RESEARCH ARTICLE

Gingival Enlargement in Neurofibromatosis Type 1: A Case Report and Literature Review

Ashu Bhardwaj, Ajay Mahajan

Citation Information : Bhardwaj A, Mahajan A. Gingival Enlargement in Neurofibromatosis Type 1: A Case Report and Literature Review. J Contemp Dent Pract 2010; 11 (2):57-63.

DOI: 10.5005/jcdp-11-2-57

License: CC BY-NC 3.0

Published Online: 00-03-2010

Copyright Statement:  Copyright © 2010; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

The purpose of this article is to describe a rare case of neurofibromatosis1 (NF1) of the gingiva and a review of the current literature.

Background

Neurofibromatosis1 (NF1) of the gingiva is an uncommon cause of gingival enlargement. The disease is clinically characterized by epidermal melanosis, nevi, and flabby skin or bone malformations; in addition, the lesions may undergo malignant transformation. Involvement of the gingiva with or without concurrent skin lesions has been reported only occasionally.

Case Description

A 40-year-old male patient with a history of NF1 came to us with a chief complaint of enlargement of the gums. Clinical examination revealed diffuse gingival enlargement with no signs of inflammation. The characteristic skin lesions associated with NF1 were also present. A gingival specimen was sent for biopsy.

Results

Based on the history, clinical, and histological findings, NF1 was established as the cause of the gingival enlargement.

Summary

NF1 may affect the gingival tissue; considering the neurological complications and malignant potential, NF1 must be diagnosed early and monitored regularly.

Clinical Significance

The clinician should be aware of clinical and histopathological findings of NF1 considering the fact that the condition has malignant potential.

Citation

Mahajan A, Dixit J, Bhardwaj A. Gingival Enlargement in Neurofibromatosis Type 1: A Case Report and Literature Review. J Contemp Dent Pract [Internet]. 2010 March; 11(2):057-063. Available from: http://www.thejcdp. com/journal/view/volume11-issue2-mahajan.


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  1. False gingival enlargement as a diagnostic problem: a case report. Int J Dent Hyg. 2008; 6(1):68-71.
  2. A clinical and pathological study of oral disease. J Am Med Assoc. 1941; 116:16-21.
  3. Growths of the gingiva and palate; connective tissue tumors. Oral Surg Oral Med Oral Pathol. 1948; 1(12):1098-1108.
  4. Genetics and cancer. In: Thompson & Thompson genetics in medicine. 6th ed. Philadelphia: W.B. Saunders Company; 2001. p. 311-35.
  5. Gingival enlargement. In: Newman MG, Takei H, Klokkevold P, Carranza FA. Carranza's clinical periodontology. 10th ed. Philadelphia: Saunders; 2006. p. 373-90.
  6. Neurofibromatosis: oral and radiographic manifestations. Oral Surg Oral Med Oral Pathol. 1984; 58(4):493-8.
  7. Diffuse but unilateral gingival enlargement associated with von Recklinghausen neurofibromatosis: a case report. J Clin Periodontol. 2000; 27(5):361-5.
  8. Neurofibromatosis type 1 with periodontal manifestation. A case report and literature review. Br Dent J. 2004; 196(8):457-60.
  9. Oral manifestations of neurofibromatosis types I and II. Oral Surg Oral Med Oral Pathol. 1992; 73(3):376-82.
  10. Syndromes of the head and neck. 3rd ed. New York: Oxford University Press; 1990. p. 353-416.
  11. Epidemiology of neurofibromatosis type1. Am J Med Genet. 1999; 89(1):1-6.
  12. Neurofibromas in children with neurofibromatosis 1. J Child Neurol. 2002;17(8):585-91, discussion 602-4, 646-51.
  13. Multiple neurofibromatosis with oral manifestations. J Oral Surg. 1975; 33(5):360-3.
  14. Neurofibromatosis: review and report of case. J Am Dent Assoc. 1988; 117(6):735-7.
  15. Manifestations of the tongue in Neurofibromatosis type1. Oral Dis. 2006; 12(2):125-9.
  16. Jaw and skull changes in neurofibromatosis. Oral Surg Oral Med Oral Pathol. 1988; 66(3):391-6.
  17. Robbins’ pathologic basis of disease. 5th ed. Philadelphia: W.B. Saunders; 1994.
  18. Neurofibromatosis type 1 and pregnancy. Am J Med Genet. 1996;66(1):7-10
  19. Neurofibromatosis: phenotype, natural history, and pathogenesis. 3rd ed. Baltimore: John Hopkins Press; 1999.
  20. Unusual form of recurrent giant cell granuloma of the mandible and lower extremities in a patient with neurofibromatosis type1. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999; 87(1):67-72.
  21. Bilateral intraosseous neurofibromata of the mandible. Br J Oral Maxillofac Surg. 1990; 28(5):344-6.
  22. Hyperplastic lesions of the gingiva and alveolar mucosa. A study of 175 cases. Acta Odontol Scand. 1983; 41(2):75-86.
  23. Neurofibroma of the palatal mucosa. A case report. J Periodontol. 1990; 61(7):456-8.
  24. Oral Surg Oral Med Oral Pathol Oral Radiol endod 199273376-82. s/b n. 9
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