The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 11 , ISSUE 2 ( March, 2010 ) > List of Articles

RESEARCH ARTICLE

Non-syndromic Oligodontia in Permanent Dentition of Monozygotic Twins: Report of a Rare Case

Keerthilatha M. Pai, Amar A. Sholapurkar, Rohit B. Gadda

Citation Information : Pai KM, Sholapurkar AA, Gadda RB. Non-syndromic Oligodontia in Permanent Dentition of Monozygotic Twins: Report of a Rare Case. J Contemp Dent Pract 2010; 11 (2):71-77.

DOI: 10.5005/jcdp-11-2-71

License: CC BY-NC 3.0

Published Online: 00-03-2010

Copyright Statement:  Copyright © 2010; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

To report a case of non-syndromic oligodontia involving 26 permanent teeth in monozygotic twin sisters and to discuss the possible genetic etiology, inheritance pattern and associated dental anomalies of this condition.

Background

Hypodontia constitutes one of the most common developmental anomalies in humans and is defined as developmental absence of one or more teeth with reported prevalence of 1.6 to 9.6% in the permanent dentition. Oligodontia is defined as agenesis of six or more teeth excluding third molars.

Case Report

This article describes a case of non-syndromic oligodontia involving 26 permanent teeth in monozygotic twin sisters. The twins had positive family history of hypodontia in their paternal grandmother, parental consanguinity (first cousin) and similarity in pattern of oligodontia. Root formation of permanent maxillary first molars and central incisors was delayed in both the twins.

Summary

This article reports a case of nonsyndromic oligodontia in permanent dentition of monozygotic twins. Possible genetic etiology, inheritance pattern and associated dental anomalies are discussed.

Clinical Significance

Strong genetic link associated with oligodontia help the dentist to know the possibility of its occurrence in other family members and in future generations.

Citation

Gadda RB, Pai KM, Sholapurkar AA. Non-syndromic Oligodontia in Permanent Dentition of Monozygotic Twins: Report of a Rare Case. J Contemp Dent Pract [Internet]. 2010 March; 11(2):071-077. Available from: http://www.thejcdp. com/journal/view/volume11-issue2-gadda.


PDF Share
  1. Severe hypodontia in a set of triplets. Br Dent J. 2006; 201(2):93-6.
  2. Oral and maxillofacial pathology. Philadelphia: WB Saunders; 1995. p. 60-61.
  3. Genetic basis of tooth development and dental defects. Acta Odontol Scand. 2000; 58(5):191-4.
  4. Hypodontia: 1. Clinical features and the management of mild to moderate hypodontia. Dental Update. 1994; 21:381-4.
  5. The genetics of human tooth agenesis: new discoveries for understanding dental anomalies. Am J Orthod Dentofacial Orthop. 2000; 117(6):650-6.
  6. Nonsyndromic oligodontia in permanent dentition: three siblings. Internet J Dent Sci. 2006;3(2).
  7. Congenital absence of teeth: a review with emphasis on inheritance patterns. J Am Dent Assoc. 1978; 96(2):266-75.
  8. Tooth agenesis: from molecular genetics to molecular dentistry. J Dent Res. 2008; 87(7):617-23.
  9. Hypodontia: genotype or environment? A case report of monozygotic twins. Br J Orthod. 1998; 25(3):175-8.
  10. Genetic mutations in certain head and neck conditions of interest to the dentist. J Can Dent Assoc. 2001; 67(10):583-8.
  11. Novel MSX1 frameshift causes autosomal-dominant oligodontia. J Dent Res 2006; 85(3): 267-71.
  12. Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am J Hum Genet. 2004; 74(5):1043-50.
  13. Oligodontia of the permanent dentition in two sisters with polycystic ovarian syndrome: case reports. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997; 84(4):368-71.
  14. Tooth formation in patients with oligodontia. Angle Orthod. 1993; 63(1):31-7.
  15. Treatment of a patient with oligodontia: a case report. J Contemp Dent Pract. 2008; 9(3):121-7.
  16. Severe hypodontia and asymptomatic bilaterally ectopic impacted teeth in the coronoid processes: a case report. Quintessence Int. 2004;35(7):582–3.
  17. Hypodontia: 2. The management of severe hypodontia. Dent Update. 1995; 22(1):8-11.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.