The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 12 , ISSUE 3 ( May-June, 2011 ) > List of Articles

RESEARCH ARTICLE

Unstimulated Whole Saliva Parathyroid Hormone in Postmenopausal Women with Xerostomia

Iraj Mirzaii-Dizgah, Farzaneh Agha-Hosseini

Citation Information : Mirzaii-Dizgah I, Agha-Hosseini F. Unstimulated Whole Saliva Parathyroid Hormone in Postmenopausal Women with Xerostomia. J Contemp Dent Pract 2011; 12 (3):196-199.

DOI: 10.5005/jp-journals-10024-1034

Published Online: 01-06-2011

Copyright Statement:  Copyright © 2011; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Objective

The aim of this study was to evaluate the correlation of xerostomia severity with unstimulated saliva parathyroid hormone (PTH) and to compare unstimulated whole saliva PTH between postmenopausal women with/without xerostomia.

Methods

A case-control study was carried out in 60 (30 as case and 30 as control) selected postmenopausal women with/ without xerostomia conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia inventory (XI) score was also used as an index of xerostomia severity. PTH concentration was analyzed by enzyme-linked immunosorbent assay (ELISA). Statistical analysis of Student's t-test and Spearman correlation was used.

Results

The mean unstimulated saliva PTH concentration was significantly higher but flow rate was lower in the case group compared with control. XI score correlated significantly with saliva PTH (r = 0.688, p = 0.001) and flow rate (r = – 0.529, p = 0.001).

Conclusion

Xerostomia severity correlated positively with unstimulated whole saliva PTH and negatively with saliva flow rate in this group of postmenopausal women. Thus, salivary flow rate and PTH levels appear associated with xerostomia and menopause.

Clinical significance

Salivary PTH level appears to be associated with xerostomia and menopause.

How to cite this article

Agha-Hosseini F, Mirzaii-Dizgah I. Unstimulated Whole Saliva Parathyroid Hormone in Postmenopausal Women with Xerostomia. J Contemp Dent Pract 2011;12(3):196-199.


PDF Share
  1. Oral manifestations of menopause. Compendium 1993;14:1586-91.
  2. Oral manifestations and dental treatment in menopause. Med Oral 2002;7:31-35.
  3. Improving the oral health of older people: The approach of the WHO Global Oral Health Programme. Community Dent Oral Epidemiol 2005;33(2): 81-92.
  4. Xerostomia and hyposalivation: Causes, consequences and treatment in the elderly. Drugs Aging 1999;15:103-16.
  5. Xerostomia and hyposalivation. Adv Dent Res 2000;14:48-56.
  6. Xerostomia and the geriatric patient. J Am Geriatr Soc 2002;50:35-43.
  7. The composition of unstimulated whole saliva of healthy dental students. J Contemp Dent Pract 2006;7:104-11.
  8. Minor gland and whole saliva in postmenopausal women using a low potency oestrogen (oestriol). Arch Oral Biol 2003;48:511-17.
  9. Relationship of stimulated saliva 17ƒÀ-estradiol and oral dryness in menopause. Maturitas 2009;62(2):197-99.
  10. Serum and stimulated whole saliva parathyroid hormone in menopausal women with oral dry feeling. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107(6):806-10.
  11. Relationship of stimulated whole saliva cortisol level with the severity of a feeling of dry mouth in menopausal women. Gerodontology 2010.
  12. Relationship of unstimulated whole saliva cortisol level with severity of oral dryness feeling in menopausal women. Aust Dent J 2011;56: 171-74.
  13. Stimulated and unstimulated saliva progesterone in menopausal women with oral dryness feeling. Clin Oral Investig 2010.
  14. Do cyclic AMP concentrations in saliva reflect PTH biologic activity? Metabolism 1985;34(6):505-08.
  15. Dynamics of parathyroid hormone secretion in health and secondary hyperparathyroidism. Clin J Am Soc Nephrol 2007;2:1283-305.
  16. Stimulated whole salivary flow rate and composition in menopausal women with oral dryness feeling. Oral Dis 2007;13: 320-23.
  17. Relationship of lumbar spine bone mineral density and oral dryness feeling in menopause. Menopause 2011.
  18. Relationship between salivary flow rates and candida counts in subjects with xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:149-54.
  19. Further testing of the xerostomia inventory. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89:46-50.
  20. Diagnosis and treatment of xerostomia (dry mouth). Odontology 2009;97(2):76-83.
  21. The effect of menopause, hormone replacement therapy (HRT), alendronate (ALN), and calcium supplements on saliva. J Contemp Dent Pract 2005;6: 10-17.
  22. Low unstimulated salivary flow and subjective oral dryness: Association with medication, anxiety, depression, and stress. J Dent Res 2000;79:1652-58.
  23. Resting and stimulated whole salivary flow rates in Sjogren's syndrome patients over time: A diagnostic aid for subsidized dental care? Acta Odontol Scand 2004;62(5):264-68.
  24. The relationship between the levels of salivary cortisol and the presence of xerostomia in menopausal women. A preliminary study. Med Oral Patol Oral Cir Bucal 2006;11(5):E407-12.
  25. How much saliva is enough for avoidance of xerostomia? Caries Res 2004;38:236-40.
  26. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001;22: 477-501.
  27. Hormone replacement therapy and some salivary antimicrobial factors in post and perimenopausal women. Maturitas 1997;27:145-51.
  28. Suppression of parathyroid hormone secretion with oral calcium in normal subjects and patients with primary hyperparathyroidism. J Clin Endocrinol Metab 1990; 70:951-56.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.