The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 12 , ISSUE 6 ( November-December, 2011 ) > List of Articles

RESEARCH ARTICLE

Alterations in Serum Lipid Profile Patterns in Oral Squamous Cell Carcinoma Patients

Gaurav Ghosh, Krithika M Jayaram, Rekha V Patil, Sangeeta Malik

Citation Information : Ghosh G, Jayaram KM, Patil RV, Malik S. Alterations in Serum Lipid Profile Patterns in Oral Squamous Cell Carcinoma Patients. J Contemp Dent Pract 2011; 12 (6):451-456.

DOI: 10.5005/jp-journals-10024-1075

Published Online: 01-08-2012

Copyright Statement:  Copyright © 2011; The Author(s).


Abstract

Aim

Altered lipid profile patterns have been associated with malignancies because lipids play a pivotal role in the maintenance of cell integrity. The present study evaluated alterations in serum lipid profile in oral squamous cell carcinoma patients as well as its association with the habit of tobacco consumption.

Materials and methods

The study included 30 oral squamous cell carcinoma patients, 20 patients with the habit of tobacco consumption and 20 controls. Serum lipids, including (i) total cholesterol, (ii) LDL cholesterol (LDLC), (iii) HDL cholesterol (HDLC), (iv) VLDL cholesterol (VLDLC) and (v) triglycerides, were analyzed by spectrophotometric kits.

Results

A significant decrease in serum total cholesterol (TC) levels, triglyceride levels (p = 0.007, p = 0.029 respectively) were observed in oral squamous cell carcinoma patients as compared to the healthy control group. The mean serum HDLC levels (p = 0.003) were significantly lowered in the tobacco habituates when compared to the healthy controls. The mean serum total cholesterol levels were significantly lower in subjects with oral squamous cell carcinoma (p = 0.000) as compared to the tobacco habituates. Likewise, LDLC levels and TC:HDLC ratios (p = 0.000 and p = 0.000 respectively) were significantly decreased in oral squamous cell carcinoma patients as compared to the tobacco habituates. Our data strengthens the evidence of an inverse relationship between serum lipid levels and oral squamous cell carcinoma.

Conclusion

The lower level of serum cholesterol and other lipid constituents in the patients is thought to be due to their increased usage by tumor cells for new membrane biogenesis.

Clinical significance

The lower serum lipid profile status serves as a useful indicator for gauging initial changes occurring in tumor cells. A detailed study of the cholesterol carrying lipoprotein transport mechanisms helps in better understanding of the underlying mechanisms of the regulation of serum cholesterol concentrations in cancer.

How to cite this article

Ghosh G, Jayaram KM, Patil RV, Malik S. Alterations in Serum Lipid Profile Patterns in Oral Squamous Cell Carcinoma Patients. J Contemp Dent Pract 2011;12(6): 451-456.


PDF Share
  1. Lipid peroxidation and antioxidants status in patients with oral squamous cell carcinoma. Indian J Med Res December 2005; 122:529-34.
  2. Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian Journal of Cancer 2004;41(1):25-31.
  3. Association of low plasma cholesterol with mortality for cancer at various sites in men: 17-year followup of the prospective Basel study. Am J Clin Nutr 2000;71: 569-74.
  4. Serum antioxidative vitamin levels and lipid peroxidation in gastric carcinoma patients. Cancer Lett 1999;136:89-93.
  5. Serum retinol and the inverse relationship between serum cholesterol and cancer. Br Med J 1982284152-54.
  6. Site-specific analysis of total serum cholesterol and incident cancers in the National Health and Nutrition Examination Survey I epidemiologic follow-up study. Cancer Res 1988;48:452-58.
  7. Prospective study of serum cholesterol and site-specific cancers. J Clin Epidemiol 1992;45:287-92.
  8. Serum lipids and lipoprotein disorders in cancer patients. Cancer 1987;60: 3065-70.
  9. Blood lipid profiles in children with acute lymphoblastic leukemia. Cancer 1998;83:379-84.
  10. Study of blood lipids in 30 children with a malignant hematological disease or carcinoma. Biomed. Pharmacother 1984;38:55-59.
  11. Influence of habits on masons’ blood cholesterol. Indian J Physiol Pharmacol 2003;47(4):429-34.
  12. Harper's review of biochemistry (20th ed). Lange Maruzen publications 1986.
  13. Textbook of biochemistry for medical students (5th ed). Jaypee publications 2007.
  14. Clinical chemistry (5th ed). Mosby 2005.
  15. Lippincott's illustrated reviews in biochemistry (3rd ed). Lippincott Williams and Wilkins publications 1984.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.