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VOLUME 13 , ISSUE 2 ( March-April, 2012 ) > List of Articles


Salivary Immunoglobulin Classes in Nigerians with Periodontitis

OA Olayanju, SK Rahamon, IO Joseph, OG Arinola

Citation Information : Olayanju O, Rahamon S, Joseph I, Arinola O. Salivary Immunoglobulin Classes in Nigerians with Periodontitis. J Contemp Dent Pract 2012; 13 (2):163-166.

DOI: 10.5005/jp-journals-10024-1114

Published Online: 01-04-2012

Copyright Statement:  Copyright © 2012; Jaypee Brothers Medical Publishers (P) Ltd.



To provide information on the usefulness of salivary immunoglobulin classes in the diagnosis of periodontitis.

Materials and methods

About 5 ml of unstimulated saliva was collected from 25 newly diagnosed subjects with periodontitis and 21 sex/age-matched apparently healthy individuals into plain sample bottles. The samples were collected between 9 am and 11 am at least, 1 hour after eating or washing of mouth and levels of salivary immunoglobulin classes (IgA, IgG, IgE and IgM) were determined using enzyme-linked immunosorbent assay (ELISA).


Only the mean level of IgA was significantly raised (p = 0.05) in the saliva of periodontitis patients compared with controls. The mean levels of IgG, IgM and IgE were not significantly elevated in patients with periodontitis, when compared with controls (p > 0.05).


This study showed that elevated salivary levels of IgA could be used as a screening tool for periodontitis.

Clinical significance

Identification of patients at risk and the diagnosis of active phases of periodontal disease remains a challenge due to lack of laboratory test routinely employed in the diagnosis and monitoring of patients with periodontal disease. This study showed that elevated salivary levels of immunoglobulin classes especially, IgA could be used as a screening tool for periodontitis.

How to cite this article

Olayanju OA, Rahamon SK, Joseph IO, Arinola OG. Salivary Immunoglobulin Classes in Nigerians with Periodontitis. J Contemp Dent Pract 2012;13(2):163-166.

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