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VOLUME 14 , ISSUE 1 ( January-February, 2013 ) > List of Articles

RESEARCH ARTICLE

p53 as a Neoplastic Biomarker in Patients with Erosive and Plaque Like Forms of Oral Lichen Planus

Iraj Mirzaii-Dizgah, Farzaneh Agha-Hosseini

Citation Information : Mirzaii-Dizgah I, Agha-Hosseini F. p53 as a Neoplastic Biomarker in Patients with Erosive and Plaque Like Forms of Oral Lichen Planus. J Contemp Dent Pract 2013; 14 (1):1-3.

DOI: 10.5005/jp-journals-10024-1259

Published Online: 01-02-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

Unstimulated whole salivary p53 was assessed in patients suffering from erosive and plaque-like form of oral lichen planus (OLP).

Materials and methods

Eighteen patients with erosive form, 17 patients suffering from plaque-like form and 38 noninvolvement subjects were enrolled. The unstimulated whole saliva p53 level was assayed by ELISA.

Results

The mean concentration of salivary p53 was significantly higher in patients with plaque-like form compared to both patients with erosive form and the control group.

Conclusion

We conclude that plaque like form of OLP is important in view of the potential for malignancy and is not safety form.

Clinical significance

It seems that all forms of OLP must be considered accurately, should be followed up with biannual examinations, and if possible, assessment of salivary p53 every year.

How to cite this article

Agha-Hosseini F, Mirzaii-Dizgah I. p53 as a Neoplastic Biomarker in Patients with Erosive and Plaque Like Forms of Oral Lichen Planus. J Contemp Dent Pract 2013;14(1):1-3.


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