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VOLUME 14 , ISSUE 3 ( May-June, 2013 ) > List of Articles


Histometric Study of Resorption on Replanted Teeth with Enamel Matrix-derived Protein

Marcelo Tomas de Oliveira, Luiz Guilherme Bentregani, Braulio Pasternak, Fabio Dagostin Cancelier, Diego Rocha de Jesus, Gustavo Otoboni Molina

Citation Information : de Oliveira MT, Bentregani LG, Pasternak B, Cancelier FD, de Jesus DR, Molina GO. Histometric Study of Resorption on Replanted Teeth with Enamel Matrix-derived Protein. J Contemp Dent Pract 2013; 14 (3):468-472.

DOI: 10.5005/jp-journals-10024-1346

Published Online: 01-10-2013

Copyright Statement:  Copyright © 2013; The Author(s).



Enamel matrix-derived proteins (Emdogain) stimulate the proliferation of periodontal ligament cells, contributing to their regeneration.


This study was to perform histometric assessment of root surface resorption in replanted teeth with the use of Emdogain®.

Materials and methods

Male Wistar rats (Rattus norvegicus), weighing 180 to 200 gm, were anesthetized, subjected to extraction of the upper right incisor tooth, which was then replanted into the alveoli with the following treatment: (a) control group - tooth with root canal filled with calcium hydroxide paste and (b) treated group - tooth with root canal filled with enamel matrix-derived protein. The animals were sacrificed 25 days after tooth replantation. The maxilla was processed to obtain thin sections (6 ì) and stained with hematoxylin and eosin. The resorption volume percentage of each dental element was calculated from the cementoenamel junction to the apex.


Quantification of resorption revealed that Emdogaintreated teeth showed a lower percentage of resorption (31.58%) compared to controls (80.48%) (statistically significant values – t-test p-value = 0.0431).


It was concluded that Emdogain used as root canal filling has properties capable of showing a lower percentage of resorption in replanted teeth.

How to cite this article

de Oliveira MT, Bentregani LG, Pasternak B, Cancelier FD, de Jesus DR, Molina GO. Histometric Study of Resorption on Replanted Teeth with Enamel Matrix-derived Protein. J Contemp Dent Pract 2013;14(3):468-472.

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