The Journal of Contemporary Dental Practice

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 14 , ISSUE 5 ( September-October, 2013 ) > List of Articles


Comparison of the Serum Immunoglobulin IgM Level in Diabetic and Nondiabetic Patients with Chronic Periodontitis

TS Srinivasa, Reena Kulshrestha, J Kranthi, KNV Sudhakar, PV Krishnam Raju, Ankur Razdan

Citation Information : Srinivasa T, Kulshrestha R, Kranthi J, Sudhakar K, Raju PK, Razdan A. Comparison of the Serum Immunoglobulin IgM Level in Diabetic and Nondiabetic Patients with Chronic Periodontitis. J Contemp Dent Pract 2013; 14 (5):814-818.

DOI: 10.5005/jp-journals-10024-1408

Published Online: 00-10-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.



To evaluate and compare the serum IgM level in diabetic and nondiabetic patients with chronic periodontitis.

Materials and methods

A total of 60 patients were selected for the study and divided into four groups, diabetic with periodontitis, diabetic without periodontitis, nondiabetic with periodontitis and nondiabetic without periodontitis (control) were analyzed for the quantitative estimation of serum immunoglobulins M by turbidimetric immunoassay. The serum of the diabetic and nondiabetic patients was evaluated and turbidimetric method was used for immunological assay by using Quantia IgM turbidimetric immunoassay for estimation of immunoglobulin IgM in human serum. The data for the level of immunoglobulin thus obtained were compared with clinically healthy patient taken as control. Sugar level was estimated the by checking the random blood sugar level by glucose test kit based on end point and kinetic assay and compared with the HbA1c percentage of the patients, by using NycoCard Reader.


The group A patients having diabetes with periodontitis showed nonsignificant increase in serum IgM level as compared to controls and other groups. Group B showed significance of p = 0.074. Group C showed significance of p = 0.982 and group D showed significance of p = 0.520. There was significant increase in HbA1c with an increase percentage serum IgM.


In the present study, significantly high concentrations of the IgM in serum of diabetic and nondiabetic patients were found as compared to the healthy subjects who had neither diabetes nor periodontitis.

Clinical significance

By this study, we can emphasize on the fact of the importance of the immune system and its correlation with glycemic control, especially in patients diagnosed with periodontitis, also suggests that the alteration in immune response in poorly controlled diabetic patients may contribute to the pathogenesis of periodontitis and is the cause of increased incidence of periodontitis in patients with diabetes.

How to cite this article

Kranthi J, Sudhakar KNV, Kulshrestha R, Raju PVK, Razdan A, Srinivasa TS. Comparison of the Serum Immunoglobulin IgM Level in Diabetic and Nondiabetic Patients with Chronic Periodontitis. J Contemp Dent Pract 2013;14(5):814-818.

PDF Share
  1. Periodontitis and diabetes interrelationships: role of inflammation. Ann Periodontol 2001;6:125-137.
  2. Diabetes and periodontal infection: making the connection. Clin Diabetes 2005;23:171-178.
  3. Periodontal disease and C-reactive protein-associated cardiovascular risk. J Periodontol Res 2004;39:236-242.
  4. Periodontal disease as part of the insulin resistance syndrome in diabetic patients. J Int Acad Periodontol 2005;7:16-20.
  5. The relationship between periodontal diseases and diabetes: an overview. Ann Periodontol 2001;6:91-98.
  6. Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Ann Periodontol 2001;6:99-112.
  7. Diagnosis, classification and pathogenesis of diabetes mellitus. Rev Esp Cardiol 2002 May;55(5):528-535.
  8. Periodontopathogens: bacteriology of periodontal disease: mini review. J Pure Applied Microbiol 2013 Mar;7(1):583-586.
  9. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Report of a WHO Consultation. Geneva: WHO; 1999. p. 1-33.
  10. Alterations in HbA1c following minimal or enhanced nonsurgical, nonantibiotic treatment of gingivitis or mild periodontitis in type 2 diabetic patients: a pilot trial. J Contemp Dent Pract 2008 Jul;9(5):9-16.
  11. Periodontal Disease: associations with diabetes, glycemic control and complications. Oral Dis 2008;14:191-203.
  12. Comparison of neutrophil chemotactic response in diabetic patients with mild and severe periodontal disease. J Periodontol 1981;52:410-415.
  13. Diabetes and periodontal disease: a bidirectional relationship. Med and Biol 2007;14(1):6-9.
  14. Diabetes mellitus and periodontal disease. Periodontology 2007;44:127-153.
  15. Periodontal microbial ecology. Periodontol 2000 2005;38:135-187.
  16. Inflammatory mediator response as a potential risk marker for periodontal in insulin-dependent diseases diabetes mellitus patients. J Periodontol 1997;68:127-135.
  17. Enhanced interaction of advanced glycation end products with their cellular receptor RAGE: implications for the pathogenesis of accelerated periodontal disease in diabetes. Ann Periodontol 1998;3:13-19.
  18. Enzyme activity in crevicular fluid in relation to metabolic control of diabetes and other periodontal risk factors. J Periodontol 1993;64:358-362.
  19. Epidemiological and clinical aspects of periodontal disease in diabetics. Ann Periodontol 1998;3:3-12.
  20. A longitudinal study on insulin dependent diabetes mellitus and periodontal disease. J Clin Periodontol 1993;20:161-165.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.