The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 14 , ISSUE 6 ( November-December, 2013 ) > List of Articles

RESEARCH ARTICLE

The Use of Controlled Release Locally Delivered 10% Doxycycline Hyclate Gel as an adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis: Clinical and Microbiological Results

Md Jalaluddin, Shabeer Ahamed, Imran Khalid, Ninad Moon, TK Shafi, Fareedi Mukram Ali

Citation Information : Jalaluddin M, Ahamed S, Khalid I, Moon N, Shafi T, Ali FM. The Use of Controlled Release Locally Delivered 10% Doxycycline Hyclate Gel as an adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis: Clinical and Microbiological Results. J Contemp Dent Pract 2013; 14 (6):1080-1086.

DOI: 10.5005/jp-journals-10024-1455

Published Online: 01-12-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background

Local delivery of antimicrobial agents provides higher concentration of the drug in the periodontal site for longer periods than systemically delivered methods. In the present study an attempt is made to know the efficacy of controlled local drug delivery of doxycycline as an adjunctive treatment in the management of chronic periodontitis.

Materials and methods

A total of 12 patients, diagnosed as Chronic Periodontitis in the age of 25 to 55 years, were selected of both the sexes in this study. They were divided into Experimental group consisted of 30 sites who received complete scaling and root planing (SRP) followed by placement of Atridox gel and control group consisted of 30 sites who received only SRP. Clinical parameters were recorded at, baseline, days 30, 90 and 180. Parameters were plaque index, gingival index, gingival bleeding index and microbial analysis, probing pocket depth and Clinical attachment level (CAL). The microbiological analysis was done at baseline visit and at 90th day. Probing pocket depth and CAL were recorded only on day 0 and 180th day.

Results

In 180 days study, both the groups exhibited a significant improvement in periodontal status. Significant gain in attachment level was observed in both the group. Between both the groups the clinical parameters in the experimental groups exhibited better results as compared to the control group. Both the groups exhibited significant reduction in the number of spirochetes.

Conclusion

Combination therapy of SRP and 10% DH gel demonstrated better results at all levels suggesting that this therapy can play a significant role as an adjunct to SRP in the management of chronic periodontitis.

How to cite this article

Ahamed S, Jalaluddin Md, Khalid I, Moon N, Shafi TK, Ali FM. The Use of Controlled Release Locally Delivered 10% Doxycycline Hyclate Gel as an adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis: Clinical and Microbiological Results. J Contemp Dent Pract 2013;14(6):1080-1086.


PDF Share
  1. A randomized placebo – controlled trial of doxycycline: effect on the microflora of recurrent periodontitis lesions in high risk patients. J Periodontol 1991;62:197-202.
  2. Periodontal pocket treatment in beagle dogs using subgingival doxycycline from a biodegradable system. Initial clinical responses. J Periodontol 1996;67:1176-1184.
  3. Two 9 months multicenter studies evaluating locally delivered doxycycline hyclate 8.5%, placebo control oral hygiene and scaling and root planing in the treatment of periodontitis. J Periodontol 1999;70:490-503.
  4. The effects of sustained release doxycycline on the anaerobic flora and antibiotic resistant patterns in subgingival plaque and saliva. J Periodontol 2000;71:768-774.
  5. Periodontal diseases in pregnancy (2) correlation between oral hygiene and periodontal condition. Acta Odontol Scan 1964;24:747-759.
  6. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975;25:229-235.
  7. A modified gingival index for use in clinical trials. Clin Prev Dent 1986;8:3-6.
  8. The effectiveness of subgingival scaling and root planing in calculus removal. J Periodontol 1981;52:119-123.
  9. Scaling and root planing efficacy in multirooted teeth. J Periodontol 1989;60:402-409.
  10. Periodontal disease treatment by local drug delivery. J Periodontol 1985;56:265-272.
  11. Controlled – release local delivery antimicrobials in periodontics: prospects for the future. J Periodontol 1993;64:782-791.
  12. The role of local drug delivery in the management of periodontal diseases: a comprehensive review. J Periodontol 1998;69:507-520.
  13. Multicenter comparative evaluation of subgingivally delivered sanguinarine and doxycycline in the treatment of periodontitis. II. Clinical results. J Periodontol 1997;68:119-126.
  14. Locally delivered doxycycline improves the healing following nonsurgical periodontal therapy in smokers’. J Clin Periodontol 2004;31:589-595.
  15. Locally delivered Doxycycline as an adjunctive therapy to scaling and root planing in the treatment of smokers: a clinical study. J Periodontol 2004;75:464-469.
  16. Evaluation of periodontal treatments using controlled-release tetracycline fibers: microbiological response. J Periodontol 1995;66:700-707.
  17. The pharmacokinetic profile of a biodegradable controlledrelease delivery system containing doxycycline compared to systemically delivered doxycycline in gingival crevicular fluid, saliva and serum. J Periodontol 1998;69:1085-1091.
  18. A 4 quadrant comparative study of periodontal treatment using tetracycline containing drug delivery fibers and scaling. J Clin Periodontol 1991;18:111-116.
  19. Controlled local delivery of tetracycline with polymer strips in the treatment of periodontitis. J Periodontol 2002 Jan;73(1):13-19.
  20. Discussion: design issue specific to studies of periodontitis. J Periodontol Res 1992(spec issue);27: 412-416.
  21. Multicentre evaluation of Tetracycline fiber therapy. II clinical responses. J Periodont Res 1991;26:371-379.
  22. A 6-month multicenter evaluation of adjunctive tetracycline fiber therapy used in conjunction with scaling and root planing in maintenance patients: clinical results. J Periodontol 1994;65:685-691.
  23. Relative distribution of bacteria at clinically healthy and periodontally disease sites in human. J Clin Periodontol 1978;5:115-132.
  24. Relation of motility of subgingival microflora as a clinical parameter to periodontal disease status in human subjects. J Clin Periodontol 2000;27:405-410.
  25. The effect of plaque control after scaling and root planing on the subgingival microflora in human periodontitis. J Clin Periodontol 1987;14:295-299.
  26. Variations in subgingival microflora from healthy and intervention sites using probing depth and bacteriologic identification criteria. J Periodontol 1984;55: 391-397.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.