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VOLUME 15 , ISSUE 4 ( July-August, 2014 ) > List of Articles

RESEARCH ARTICLE

Clinicopathologic Evaluation of Lesions associated with Tobacco Usage

Yalamanchili Samatha, Avula Jogendra Sai Sankar, KS Ganapathy, Kandula Srinivas, Dasari Ankineedu, Alluri Leela Subhashini Choudary

Citation Information : Samatha Y, Sankar AJ, Ganapathy K, Srinivas K, Ankineedu D, Choudary AL. Clinicopathologic Evaluation of Lesions associated with Tobacco Usage. J Contemp Dent Pract 2014; 15 (4):466-472.

DOI: 10.5005/jp-journals-10024-1564

Published Online: 01-08-2014

Copyright Statement:  Copyright © 2014; The Author(s).


Abstract

Introduction

Tobacco usage in different forms is the single most common etiological factor responsible for oral cancers. The aim of the present study was to record various mucosal lesions associated with tobacco usage and to ascertain the prevalence of dysplasia in them by histopathological evaluation and to compare the extent of dysplastic features seen among patients associated with a habit of smoked and smokeless form of tobacco.

Materials and methods

Seventy-six patients with the clinical diagnosis of tobacco related lesions (Leukoplakia, Erythroplakia, Nicotina stomatitis, Tobacco pouch keratosis) were selected. A detailed description of the clinical presentation of the lesion was noted and the patients were subjected to incisional biopsy followed by a histopathological evaluation.

Results

Showed dysplastic changes in 50 cases (65.8%) ranging from mild dysplasia in 27 cases (35.5%), moderate dysplasia in 17 cases (22.4%) and 6 cases (7.9%) showed severe dysplasia. Moderate to severe dysplasia was 1.83 times more likely to occur with smokeless tobacco usage when compared to smoked form. Data obtained from this study reveals that patients with a duration of tobacco usage more than 10 years were 2.17 times more likely to have moderate to severe dysplasia (p = 0.154).

Conclusion

Thus, the study highlights the role of oral physicians in detecting oral mucosal lesions and screening high-risk patients on a regular basis and also reaffirms the importance of public education, stressing the risk factors for oral cancers.

How to cite this article

Samatha Y, Sankar AJS, Ganapathy KS, Srinivas K, Ankineedu D, Choudary ALS. Clinicopathologic Evaluation of Lesions associated with Tobacco Usage. J Contemp Dent Pract 2014;15(4):466-472.


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  1. The oral effects of tobacco abuse. J Amer Dent Inst Cont Educ 1992;43:3-17.
  2. Tobacco-related oral mucosal lesions and conditions in India, Basic Dental Research Unit, Tata Institute of Fundamental Research, Bombay, India 1993.
  3. Evaluation of screening for oral cancer and precancer in a company headquarters. Community Dentistry and Oral Epidemiology 1995;23(2):84-88.
  4. Pathologic basis of disease. 5th ed. Philadelphia. WB Saunders Company 1992.
  5. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;79(3):321-329.
  6. Premalignant lesions of the oral mucosa. A discussion about the place of oral intraepithelial neoplasia (OIN). Oral Oncol 2002;38:125-130.
  7. Epidemiologic and histologic study of oral cancer and leukoplakia among 50915 villagers in India. Cancer 1969;24(4):832-849.
  8. An epidemiologic study of oral cancer and precancerous conditions among 101761 villagers in Maharashtra, India. Int J Cancer 1972;10(1):134-141.
  9. Smokeless tobacco use and oral epithelial dysplasia. Cancer 1989;64(7):1527-1530.
  10. Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10-year follow-up-study of Indian villagers. Community Dent Oral Epidemiol 1980;8(6):287-333.
  11. Leukoplakia: an epidemiologic study of 1504 cases observed at the Tata Memorial Hospital Bombay, India. Br J Cancer 1971;25(4):657-668.
  12. Bidi smoking and oral cancer: a meta-analysis. Int J Cancer 2003;106(4):600-604.
  13. Tobacco use and cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;80(2):178-182.
  14. Observations on the clinical characteristics of oral lesions showing histologic epithelial dysplasia. Oral Surg Oral Med Oral Path 1972;33(3):389-399.
  15. The prevalence of oral lesions in smokeless tobacco users and an evaluation of risk factors. Cancer 1992;70(11):2579-2585.
  16. Betel quid without tobacco as a risk factor for oral precancers. Oral Oncol 2004;40(7):697-704.
  17. Risk factors for oral epithelial dysplasia: the role of smoking and alcohol. Oral Oncol 1999;35(2):151-156.
  18. The role of alcohol in nonsmokers and tobacco in nondrinkers in the aetiology of oral epithelial dysplasia. Int J Cancer 1998;77(3):333-336.
  19. Toombak-associated oral mucosal lesions in Sudanese show a low prevalence of epithelial dysplasia. J Oral Pathol Med 1996;25(5):239-244.
  20. Clinical risk factors of oral leukoplakia in a representative sample of the US population. Oral Oncol 2004;40(2):158-163.
  21. Oral Oncology 1998;34(4):270-275.
  22. Progress in determining the malignant potential of oral lesions. J Oral Pathol Med 2003;32(5):251-256.
  23. Oral epithelial dysplasia: clinical characteristics of western European residents. Oral Oncol 2003;39(6):589-596.
  24. ‘When is an oral leukoplakia premalignant?’ Oral Oncology2002;38(8):813-814.
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