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VOLUME 15 , ISSUE 5 ( September-October, 2014 ) > List of Articles


The Effect of Temperature on Bisphenol: An Elution from Dental Resins

Didem Atabek, Itir Aydintug, Alev Alaçam, Aysel Berkkan

Citation Information : Atabek D, Aydintug I, Alaçam A, Berkkan A. The Effect of Temperature on Bisphenol: An Elution from Dental Resins. J Contemp Dent Pract 2014; 15 (5):576-580.

DOI: 10.5005/jp-journals-10024-1582

Published Online: 01-02-2015

Copyright Statement:  Copyright © 2014; The Author(s).



Bisphenol A (BPA) elution from baby bottles into content has been of great public interest and debate in recent year. Uncontrolled BPA elution due to temperature increase may create a risk factor for human health. However, dental resins that are used in pediatric dentistry also have BPA derivatives. The aim of this study is to evaluate BPA elution from dental resins and to determine the effect of temperature increase on this elution.

Materials and methods

Four dental resins containing BPA derivatives (Filtek Z250, Filtek Supreme XT, Fissurit FX, and Admira) and a control group (BPA free G-aenial) were used in this study. Each specimen was stored in 2 ml of 75% ethanolwater solution at 37°C. Water at a temperature of 59°C ± 1°C (preferred temperature of hot drinks) was added to the study samples at certain time intervals (1, 6, 24 hours and 2, 3, 4, 5 and 6 days). The methanol samples were analyzed using high-performance liquid chromatography (HPLC). Data was analyzed using multivariate and repeated measures analysis of variance (p < 0.05).


The study samples generally eluted more BPA than the control samples (p < 0.05). The greatest amount of BPA for an individual time period was measured after 6 hours for the groups A to D; the same was found after 24 hours for group E.


While the BPA elution levels evaluated in the study samples were more than control samples, all measured values were under the reference levels and the amounts do not constitute a risk.

Clinical significance

Resin-based dental materials can act as a source of BPA (within safety margins), especially when they react with hot water.

How to cite this article

Atabek D, Aydintug I, Alaçam A, Berkkan A. The Effect of Temperature on Bisphenol: An Elution from Dental Resins. J Contemp Dent Pract 2014;15(5):576-580.

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  1. Bisphenol A and related compounds in dental materials. Pediatrics 2010 Oct;126(4):760-768.
  2. Bisphenol A and children's health. Curr Opin Pediatr 2011 Apr;23(2):233-239.
  3. Exposure to bisphenol A from bisglycidyl dimethacrylate-based dental sealants. J Am Dent Assoc 2006 Mar;137(3):353-362.
  4. Is there a risk of harm or toxicity in the placement of pit and fissure sealant materials? A systematic review. J Can Dent Assoc 2008 Mar;74(2):179-183.
  5. Timerelated bisphenol-A content and estrogenic activity in saliva samples collected in relation to placement of fissure sealants. Clin Oral Investig 1999 Sep;3(3):120-125.
  6. Pharmacokinetics of bisphenol A released from a dental sealant. J Am Dent Assoc 2000 Jan;131(1):51-58.
  7. Determination of bisphenol A and related aromatic compounds released from Bis-GMAbased composites and sealants by high performance liquid chromatography. Environ Health Perspect 2000 Jan;108(1):21-27.
  8. Bis-GMA-based resins in dentistry: are they safe? J Am Dent Assoc 1999 Feb;130(2):201-209.
  9. Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect 1996 Mar;104(3):298-305.
  10. Bisphenol-A content of resin monomers and related degradation products. Clin Oral Investig 1999 Sep;3(3):114-119.
  11. Long-term release of monomers from modern dental-composite materials. Eur J Oral Sci 2009 Feb;117(1):68-75.
  12. Salivary bisphenol-A levels detected by ELISA after restoration with composite resin. J Mater Sci Mater Med 2005 Apr;16(4):297-300.
  13. Detection of bisphenol-A in dental materials by gas chromatography-mass spectrometry. Dent Mater J 2000 Mar;19(1):75-86.
  14. Monomer elution from nanohybrid and ormocer-based composites cured with different light sources. Dent Mater 2011 Apr;27(4):371-378.
  15. How much do resin-based dental materials release? A metaanalytical approach. Dent Mater 2011 Aug;27(8):723-747.
  16. Release of bisphenol-A from a light-cured adhesive bonded to lingual fixed retainers. Am J Orthod Dentofacial Orthop 2011 Feb;139(2):192-195.
  17. Cytotoxicity of dental composites and their leached components. Quintessence Int 2007 Oct;38(9):789-795.
  18. At what temperature do consumers like to drink coffee?: Mixing methods. J Food Sci 2002 Sep;67(7):2774-2777.
  19. A review of dietary and non-dietary exposure to bisphenol-A. Food Chem Toxicol 2012 Oct;50(10):3725-3740.
  20. Analysis of Bisphenol A in milk by using a multicommuted fluorimetric sensor. Talanta 2012 Jul 15;96:195-201.
  21. Minimizing patients’ exposure to uncured components in a dental sealant. J Am Dent Assoc 1999 Dec;130(12):1751-1757.
  22. HPLC analysis of eluted monomers from two composite resins cured with LED and halogen curing lights. J Biomed Mater Res B Appl Biomater 2009 Jan;88(1):191-196.
  23. Elution study of unreacted Bis-GMA, TEGDMA, UDMA, and Bis-EMA from light-cured dental resins and resin composites using HPLC. J Biomed Mater Res B Appl Biomater 2005 Jul;74(1):617-626.
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