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VOLUME 15 , ISSUE 6 ( November-December, 2014 ) > List of Articles


Evaluation of the Effect of Diacetyl Morphine on Salivary Factors and their Changes after Methadone Therapy

Majid Akbari, Reza Afshari, Mahsa Sharifi, Seyed Isaac Hashemy, Sara Majidinia, Naser Karimian Tousi

Citation Information : Akbari M, Afshari R, Sharifi M, Hashemy SI, Majidinia S, Tousi NK. Evaluation of the Effect of Diacetyl Morphine on Salivary Factors and their Changes after Methadone Therapy. J Contemp Dent Pract 2014; 15 (6):730-734.

DOI: 10.5005/jp-journals-10024-1607

Published Online: 01-04-2015

Copyright Statement:  Copyright © 2014; The Author(s).



Psychoactive drugs are responsible for pathological changes in the mouth including dental caries, which most troublesome. The aim of the present study was to evaluate the effect of heroin on several salivary factors which are involved in the oral health and their changes after methadone maintenance therapy (MMT).

Materials and methods

Forty patients with heroin abuse history, who referred to Imam Reza Hospital for MMT were included.

Saliva sampling was carried out two times; at the first visit (time 1) and repeated 1 month after MMT (time 2). The saliva was analyzed immediately to evaluate the total volume, Ph, CPR, the Uric acid concentration, nitric oxide and antioxidant capacity.


The mean values for saliva volume, pH, CRP, Uric acid, antioxidant and nitric oxide were 0.38 ± 0.14, 7.63 ± 1.22, 5.2 ± 2.3, 1.47 ± 0.8, 0.80 ± 0.23, and 0.26 ± 0.03, respectively at first visit and 0.34 ± 0.22, 7.37 ± 1.01, 6.1 ± 2.6, 2.18 ± 0.9, 0.74 ± 0.3 and 0.29 ± 0.08 after 1 month of MMT.

These values are below the normal ranges; however, there was no significant difference between two times in term of saliva volume, pH and saliva component (p > 0.05).


Heroin addiction changed the effective salivary factors and therefore could negatively contribute to oral health. These factors were not return to the normal range after 1 month of MMT. Physicians should be informed about focusing on oral health in patients under MMT.

Clinical significance

Heroin addiction changed the effective salivary factors and these factors were not return to the normal range after 1 month of MMT.

How to cite this article

Akbari M, Afshari R, Sharifi M, Hashemy SI, Majidinia S, Tousi NK. Evaluation of the Effect of Diacetyl Morphine on Salivary Factors and their Changes after Methadone Therapy. J Contemp Dent Pract 2014;15(6):730-734.

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