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VOLUME 16 , ISSUE 4 ( April, 2015 ) > List of Articles

CASE REPORT

Nonsurgical Management of Phenytoin-induced Gingival Hyperplasia

Yousef A AlJehani

Citation Information : AlJehani YA. Nonsurgical Management of Phenytoin-induced Gingival Hyperplasia. J Contemp Dent Pract 2015; 16 (4):319-321.

DOI: 10.5005/jp-journals-10024-1683

Published Online: 01-09-2015

Copyright Statement:  Copyright © 2015; The Author(s).


Abstract

Introduction

The aim of this report is to present a severe case of phenytoin (PHT)-induced gingival hyperplasia in a Saudi patient.

Materials and methods

A 12-year-old male epileptic patient, undergoing PHT therapy, was diagnosed clinically with severe gingival hyperplasia. His treatment consisted meticulous oral care and weekly professional prophylaxis. The patient was advised oral folic acid supplementation (0.5 mg/day) and was also recommended 0.2% chlorhexidine gluconate mouthwash twice daily.

Results

There was significant reduction in the hyperplastic tissue within 4 weeks of treatment.

Conclusion

It is possible to treat PHT-induced gingival hyperplasia non-surgically with intensive dental care, correct oral hygiene and oral folic acid supplements.

How to cite this article

AlJehani YA. Nonsurgical Management of Phenytoin-induced Gingival Hyperplasia. J Contemp Dent Pract 2015;16(4):319-321.


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  1. Understanding the patient with epilepsy and seizures in the dental practice. J Can Dent Assoc 2007;73(1):71-76.
  2. The pathogenesis of druginduced gingival overgrowth. J Clin Periodont 1996;23(3):165-175.
  3. Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. Epilepsia 1996;37(s1):S74-S80.
  4. Drug-induced gingival overgrowth. Oral Surg Oral Med Oral Pathol 1993;76(4):543-548.
  5. Folic acid and phenytoin induced gingival overgrowth—is there a preventive effect. J Ind Soc Pedod Prev Dent 2004;22(2):82-91.
  6. A clinical review of drug-induced gingival overgrowths. Aust Dent J 1999;44(4):219-232.
  7. Effect of folic acid on recurrence of phenytoin-induced gingival overgrowth following gingivectomy. J Clin Periodont 1991;18(2):134-139.
  8. Administration of folic acid to institutionalized epileptic adults with phenytoin induced gingival hyperplasia: a double blind, randomised, placebo controlled parallel study. Oral Surg Oral Med Oral Pathol 1991;71:565.
  9. Incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients in general medical practice. Community Dent Oral Epidemiol 1992;20(5):288-291.
  10. Phenytoin as a risk factor in gingival hyperplasia. Ther Drug Monit 1995;17(5):445-448.
  11. Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth. J Clin Periodontol 1998;25(1):42-47.
  12. J Am Med Assoc 1939;112:1244-1939.
  13. Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children. Neurology 2011;76(15):1338-1343.
  14. Practice parameter update: management issues for women with epilepsy—focus on pregnancy (an evidence-based review): Vitamin K, folic acid, blood levels, and breastfeeding Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 2009;73(2):142-149.
  15. The subgingival microflora in phenytoin-induced gingival hyperplasia. J Periodontal Res 2003;38(5):477-481.
  16. Drug-induced gingival hyperplasia in transplant recipients. Progress in Transplantation 2002;12(1):17-23.
  17. Idiopathic gingival hyperplasia and orthodontic treatment: a case report. J Orthod 2003;30(1):13-19.
  18. J Clin Periodont 2006;33(6):434-439.
  19. Effectiveness of periodontal treatments on cyclosporine-induced gingival overgrowth in transplant patients. Br Dent J 1997;183(3):89-94.
  20. A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report. Acta Neurol Scand 1994;90(5):367-370.
  21. Effects of a chlorhexidine gluconate-containing mouthwash on the vitality and antimicrobial susceptibility of in vitro oral bacterial ecosystems. Appl Environ Microbiol 2003;69(8):4770-4776.
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