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VOLUME 16 , ISSUE 5 ( May, 2015 ) > List of Articles


Evaluation of the Effects of Dental Implants on Oral Lesions

Farzaneh Agha-Hosseini, Bita Rohani

Citation Information : Agha-Hosseini F, Rohani B. Evaluation of the Effects of Dental Implants on Oral Lesions. J Contemp Dent Pract 2015; 16 (5):400-406.

DOI: 10.5005/jp-journals-10024-1697

Published Online: 01-05-2015

Copyright Statement:  Copyright © 2015; Jaypee Brothers Medical Publishers (P) Ltd.



To determine whether dental implants impress oral lesions, and to evaluate the nature of their effect on the lesions.

Materials and methods

A comprehensive search was done via Google and PubMed for articles (including case reports and literature reviews) containing the keywords ‘oral squamous cell carcinoma’ (OSCC), ‘oral lichen planus’ (OLP), ‘lichenoid contact reaction’ (LCR), ‘osseointegrated implants’, and ‘dental implants’, in the last 10 years (2002-2012).


The study included 24 articles involving patients with dental implants, and some oral lesions (e.g. oral lichen planus and oral squamous cell carcinoma) or with a history of lesions. In these publications, there is evidence suggesting the possibility of emergence, exacerbation, recurrence, or even malignant transformation of the oral lesions after implant placement in some cases.


Based on our review of the literature, implant treatment does not seem to be completely safe under any circumstances, but may have some complications in subjects with certain diseases (e.g. oral lesions, autoimmune diseases, malignancies, allergic reactions, etc.). Therefore prior to treatment, patients should be fully informed of the risks.

Clinical significance

Implant treatment is best done with caution in patients with cancer or mucocutaneous disorders.

How to cite this article

Agha-Hosseini F, Rohani B. Evaluation of the Effects of Dental Implants on Oral Lesions. J Contemp Dent Pract 2015;16(5):400-406.

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  1. Journey from 2D to 3D: implant imaging a review. Int J Contemp Dent Med Rev 2014, Article ID 091114. doi: 10.15713/ins.ijcdmr.
  2. Dental implants in patients with oral mucosal alterations: an update. Med Oral Patol Oral Cir Bucal 2011;16(6):e787-793.
  3. Oral lichen planus and dental implants. Int J Oral Maxillofac Surg 2006;35(3):237-240.
  4. Implant retained overdentures for two patients with severe lichen planus: a clinical report. J Prosthet Dent 2003;89(1):6-10.
  5. Dental implants and squamous cell carcinoma in the at risk patient-report of three cases. Br Dent J 2008;205(10):543-545.
  6. squamous cell carcinoma recurrence around dental implants. J Oral Maxillofac Surg 2010;68(10):2507-2512.
  7. Further malignancy in field change adjacent to osseointegrated implants. Int J Oral Maxillofac Surg 2004;33(4):353-355.
  8. Oral squamous cell carcinoma in association with dental osseointegrated implants. Arch Otolaryngol Head Neck Surg 1996;122:1402-1403.
  9. Squamous cell carcinoma appearing as peri-implants bone loss: a case report. J Oral Maxillofac Surg 2001;59:1349-1352.
  10. Peri-implantitis or squamous cell carcinoma. Rev Stomatol Chir Maxillofac 2007;108:458-460.
  11. Oral squamous cell carcinoma around dental implants. Quintessence Int 2006;37(9):707-711.
  12. Squamous cell carcinoma associated with a mandibular staple implant. J Oral Maxillofac Surg 1997;55:1020-1022.
  13. Oral squamous cell carcinoma associated with a dental implant: a case report and literature review. J Clin Exp Dent 2011;3(2):e166-168.
  14. Epidemiology of squamous cell carcinoma of the oral cavity in Iran. J Craniofac Surg 2008;19(6):1699-1702.
  15. Oral squamous cell carcinoma: an analysis of 1,564 cases showing advances in early detection. J Oral Sci 2010;52(2):267-273.
  16. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108.
  17. Squamous cell carcinoma of the oral cavity: a case series analysis of clinical presentation and histological grading of 1,425 cases from Iraq. Clin Oral Invest 2008;12:15-18.
  18. molecular mechanisms of inflammationinduced carcinogenesis. J Clin Biochem Nutr 2006;39:103-113.
  19. Expression of pro-inflammatory protein, iNOS, VEGF and COX-2 in oral squamous cell carcinoma (OSCC), relationship with angiogenesis and their clinicopathological correlation. Med Oral Patol Oral Cir Bucal 2009;14(7):E319-324.
  20. Inflammation and cancer: how hot is the link? Biochemical Pharmacology 2006;72:1605-1621.
  21. Role of chemokines in tumor growth. Cancer Letters 2007;256:137-165.
  22. Immune activation and chronic inflammation as the cause of malignancy in oral lichen planus: is there any evidence. Oral Oncol 2004;40(2):120-130.
  23. Inflammatory chemokines in cancer growth and progression. Eur J Cancer 2006;42:760-767.
  24. Chemokines and chemokine reseptors: new insights into cancer-related inflammation. Trends Mol Med 2010;16(3):133-144.
  25. Regulation of angiostatic chemokines driven by IL-12 and IL-27 in human tumors. J Leukocyte Bio 2011;90(5):875-882.
  26. The clinicopathological significance of the expression of CXCR4 protein in oral squamous cell carcinoma. Int J Oncol 2004;25(1):65-71.
  27. CXCR4 expression is associated with lymphnode metastasis of oral squamous cell carcinoma. Int J Oncol 2006;28(1):61-66.
  28. Association of CCL2 with lymph node metastasis and macrophage infiltration in oral cavity and lip squamous cell carcinoma. Tumour Biol 2008;29:114-121.
  29. Oral and oropharyngeal squamous cell carcinomas expressing CCR7 have poor prognoses. Auris Nasus Larynx 2006;33:37-42.
  30. Chronic periodontitis and the incidence of head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2009;18(9):2406-2412.
  31. Oral lichen planus is a unique disease model for studying chronic inflammation and oral cancer. Medical Hypotheses 2010;75:492-494.
  32. Relationship between oral cancer and implants: clinical cases and systematic literature review. Med Oral Patol Oral Cir Bucal 2012;17(1):e23-28.
  33. Removal of an oral squamous cell carcinoma including parts of osseointegrated implants in the marginal mandibulectomy. Oral Maxillofac Surg 2010;14(4):253-256.
  34. Squamous cell carcinoma in association with dental implants: an assessment of previously hypothesized carcinogenic mechanisms and a case report. J Oral Implantol Epub 2011 May 16. 2012;38(6):792-798.
  35. Squamous carcinoma after dental implants: a clinical case. Rev Port Estomatol Cir Maxillofac 2008;49:97-100.
  36. Squamous cell carcinoma presenting as peri-implantitis: a case report. Ann R Coll Surg Engl 2009;91(7):w8-10.
  37. Oral squamous cell carcinoma: etiology, pathogenesis and prognostic value of genomic alterations. Ind J Cancer 2006;43:60-66.
  38. Early detection of oral cancer. Egypt J Oral Maxillofac Surg 2010;1:25-31.
  39. Immunohistochemistry Analysis of P53 and Ki-67 Proteins in Oral Lichen Planus and Normal Oral Mucosa. Iranian J Publ Health 2009;38(2):37-43.
  40. Comparative evaluation of low-level laser and CO2 laser in treatment of patients with oral lichen planus. Int J Oral Maxillofac Surg 2012;41(10):1265-1269.
  41. Efficacy of IMOD in the treatment of oral lichen planus. Open J Stomatol 2011;1:13-17.
  42. Efficacy of purslane in the treatment of oral lichen planus. Phytother Res 2010;24:240-244.
  43. Oral lichen planus-Review on etiopathogenesis. Natl J Maxillofac Surg 2011;2(1):15-16.
  44. Update on oral lichen planus: etiopathogenesis and management. Crit Rev Oral Biol Med 1998;9(1):86-122.
  45. The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med 2002;13(4):350-365.
  46. Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation. J Oral Sci 2007;49:89-106.
  47. Oxidative stress status and DNA damage in saliva of human subjects with oral lichen planus and oral squamous cell carcinoma. J Oral Pathol Med 2012;41(10):736-740.
  48. Oxidative stress markers in oral lichen planus. Biofactors 2008;33(4):301-310.
  49. A universal diagnostic criteria for oral lichen planus: an exigency. Int J Contemp Dent Med Rev 2014, Article ID 041214. doi: 10.15713/ins.ijcdmr.
  50. Relationship between human oral lichen planus and oral squamous cell carcinoma at a genomic level: a datamining study. Bioinformation 2009;4(6):258-262.
  51. Titanium implants induce expression of matrix metalloproteinases in bone during osseointegration. JRRD 2004;41(6A):757-766.
  52. Primary mineralization at the surfaces of implants. Crit Rev Oral Biol Med 2000;11(4):423-436.
  53. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001;17:463-516.
  54. Oral mucosa and skin reactions related to amalgam. Adv Dent Res 1992;6:120-124.
  55. Oral lichenoid lesions and allergy to dental materials. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2007;151(2):333-339.
  56. Allergies to dental metals. Titanium: a new allergen. Rev Med Brux 2010;31(1):44-49.
  57. Hypersensitivity to titanium: clinical and laboratory evidence. Neuro Endocrinol Lett 2006;27:31-35.
  58. Four years of clinical experience with an adverse reaction unit for dental biomaterials. Comm Dent Oral Epidemiol 2004;32:150-157.
  59. Investigation of reactions to dental materials. Br J Dermatol 2005;153(3):479-485.
  60. Titanium allergy in dental implant patients: a clinical study on 1500 consecutive patients. Clin Oral Impl Res 2008;19:823-835.
  61. Implant failure due to titanium hypersensitivity/allergy: report of a case. SADJ 2007;62(1):22,24-25.
  62. Suspected association of an allergic reaction with titanium dental implants: a clinical report. J Prosthet Dentist 2008;100(5):344-347.
  63. Reactive lesions of peri-implant mucosa associated with titanium dental implants: a report of two cases. Int J Oral Maxillofac Surg 2010;39:503-507.
  64. Peripheral giant cell granuloma associated with a dental implant. Int J Oral Maxillofac Implant 2004;19:295-296.
  65. An analysis of peripheral giant cell granuloma associated with dental implant treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:618-622.
  66. Peripheral giant cell granuloma associated with dental implants. J Periodontol 2003;74:1381-1384.
  67. Peripheral giant cell granuloma associated with a dental implant: a case report. Minerva Stomatol 2008;57:529-534.
  68. Osteoradionecrosis and dental implants. Rev Stomatol Chir Maxillofac 2008;109(6):387-391.
  69. Maxillary osteosarcoma associated with a dental implant: report of a case and review of the literature regarding implant-related sarcomas. J Am Dent Assoc 2008;139(8):1052-1059.
  70. Orthopaedic implant-related sarcoma: a study of twelve cases. Mod Pathol 2001;14(10):969-977.
  71. Malignant tumors at the site of total hip prosthesis: analytic review of 46 cases. J Arthroplasty 2006;21(3):311-323.
  72. Plasmacytoma of the mandible associated with a dental implant failure: a clinical report. Clin Oral Implants Res 2007;18(4):540-543.
  73. Breast metastasis around dental implants: a case report. Clin Implant Dent Relat Res 2007;9(2):112-115.
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