Efficacy of Autofluorescence Imaging as an Adjunctive Technique for Examination and Detection of Oral Potentially Malignant Disorders: A Systematic Review
Citation Information :
Efficacy of Autofluorescence Imaging as an Adjunctive Technique for Examination and Detection of Oral Potentially Malignant Disorders: A Systematic Review. J Contemp Dent Pract 2015; 16 (9):744-749.
Oral cancer is a serious global issue and early diagnosis of oral cancer is the key in reducing the high mortality rate. Autofluorescence properties of oral mucosa have been gaining interest in the field of early diagnosis of oral premalignant lesions.
Objective
The aim of the study was to evaluate the clinical usefulness of an autofluorescence based imaging system to detect oral premalignant and malignant lesions.
Materials and methods
A systematic review of the Englishlanguage literature to evaluate the effectiveness of visually enhanced lesion scope (VELscope) published between 1966 and March, 2014 was undertaken. Data relating to study design, sampling and characteristics of the study group, interventions, and reported outcomes and diagnostic value of VELscope were abstracted from articles meeting inclusion and exclusion criteria.
Results
Eleven articles that met the inclusion criteria were included. In nine studies, all the lesions underwent histological assessment, whereas the remaining four studies only performed histological assessment on suspicious lesions. Visually enhanced lesion scope showed high sensitivity values in detecting oral premalignant and malignant lesions. However, most of the studies reported it inability in discriminating dysplasia cases from nondysplasia cases.
Conclusion
There is insufficient evidence to support the use of VELscope in primary care setting, however, they may be useful in hands of a specialist.
How to cite this article
Awan KH, Patil S. Efficacy of Autofluorescence Imaging as an Adjunctive Technique for Examination and Detection of Oral Potentially Malignant Disorders: A Systematic Review. J Contemp Dent Pract 2015;16(9):744-749.
Cancer incidence in five continents, Vol. VIII. Lyon: IARC Scientific Publications No. 155, IARC Press; 2002.
SEER cancer statistics review, 1975-2005. bethesda: National Cancer Institute; 2008.
The experiences of young oral cancer patients in Scotland: symptom recognition and delays in seeking professional help. Br Dent J 2010;208:465-471.
Errors in the diagnosis of oral malignancies. J Can Dent Assoc 1993;59:935-938.
A systematic review of test performance in screening for oral cancer and precancer. Oral Oncol 2004;40:264-273.
Evaluation of an autofluorescence based imaging system (VELscope™) in the detection of oral potentially malignant disorders and benign keratoses. Oral Oncol 2011;47:274-277.
Utility of toluidine blue as a diagnostic adjunct in the detection of potentially malignant disorders of the oral cavity: a clinical and histological assessment. Oral Dis 2012;18:728-733.
Utility of chemiluminescence (ViziLite™) in the detection of oral potentially malignant disorders and benign keratoses. J Oral Pathol Med 2011;40:541-544.
Oral cancer: current and future diagnostic techniques. Am J Dent 2008;21:199-209.
Adjunctive techniques for oral cancer examination and lesion diagnosis: a systematic review of the literature. J Am Dent Assoc 2008;139:896-905.
Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas. J Am Dent Assoc 2010;141:509-520.
Diagnostic clinical aids in oral cancer. Oral Oncol 2010;46:418-422.
Optical diagnostics in the oral cavity: an overview. Oral Dis 2010;16:717-728.
Analysis of new diagnostic methods in suspicious lesions of oral mucosa. Med Oral Patol Cir Bucal 2009;14:E210-216.
Influence of fluorescence on screening decisions for oral mucosal lesions in community dental practices. J Oral Pathol Med 2014;43:7-13.
The detection of oral pre-malignant lesions with an autofluorescence based imaging system (VELscope™): a single blinded clinical evaluation. Head Face Med 2013;9:23.
The role of direct visual fluorescent examination (VELscope) in routine screening for potentially malignant oral mucosal lesions. Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:636-643.
Use of fluorescent light in detecting malignant and premalignant lesions in the oral cavity: a prospective, single-blind study. J Otolaryngol Head Neck Surg 2012;41:164-168.
Clinical evaluation of an autofluorescence diagnostic device for oral cancer detection: a prospective randomized diagnostic study. Eur J Cancer Prev 2012;21:460-466.
Efficacy of tissue autofluorescence imaging (VELScope) in the visualization of oral mucosal lesions. Head Neck 2012;34:856-862.
Autofluorescence imaging of potentially malignant mucosa lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111:568-577.
Direct visualization of oral-cavity tissue fluorescence as novel aid for early oral cancer diagnosis and potentially malignant disorders monitoring. Int J Immunopathol Pharmacol 2011;24:121-128.
A cross-sectional study evaluating chemiluminescence and autofluorescence in the detection of clinically innocuous precancerous and cancerous oral lesions. J Am Dent Assoc 2010;141:151-156.
Effectiveness of autofluorescence to identify suspicious oral lesions—a prospective, blinded clinical trial. Clin Oral Investig 2011;15:975-982.
Etudes sur les aspects offerts par des tumeurs experimentales examines a la lumiere de Wood. CR Soc Biol 1924;91:1423-1424.
A comparative study of normal inspection, autofluorescence and 5-ALA-induced PPIX fluorescence for oral cancer diagnosis. Int J Cancer 2002;97:245-252.