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VOLUME 17 , ISSUE 1 ( January, 2016 ) > List of Articles

RESEARCH ARTICLE

Hepatitis C and Oral Lichen Planus: Evaluation of their Correlation and Risk Factors in a Longitudinal Clinical Study

Adilson Luiz Ramos, João Paulo De Carli, Maria Salete Sandini Linden, Soluete Oliveira da Silva, Micheline Sandini Trentin, Felipe de Souza Matos

Citation Information : Ramos AL, Carli JP, Linden MS, da Silva SO, Trentin MS, de Souza Matos F. Hepatitis C and Oral Lichen Planus: Evaluation of their Correlation and Risk Factors in a Longitudinal Clinical Study. J Contemp Dent Pract 2016; 17 (1):27-31.

DOI: 10.5005/jp-journals-10024-1798

Published Online: 01-06-2016

Copyright Statement:  Copyright © 2016; The Author(s).


Abstract

Objective

The aim of this study is to evaluate the correlation between hepatitis C virus (HCV) infection and oral lichen planus (OLP), and further examine the relationship between age, sex, systemic diseases and drugs with the presence of HCV infection or OLP.

Material and methods

A longitudinal clinical study was carried out from March 2010 to December 2013 with 51 individuals, of whom 33 had been presented with HCV (HCV-positive group) and 18 had OLP (OLP-positive group), in Passo Fundo, RS, Brazil. Hepatitis C virus-positive individuals who presented lesions compatible with OLP were subjected to an intraoral biopsy for histopathological diagnosis, while OLP-positive individuals underwent anti-HCV serological test for diagnosis of HCV infection. Data on age, sex, systemic diseases and drugs used were recorded for later analysis. The data were analyzed using descriptive statistics of frequency and by Pearson's Chisquare test, with a 5% significance level (p < 0.05).

Results

Out of the 33 HCV-positive individuals, only one was clinically and pathologically positive for OLP, demonstrating a significant relationship between the presence of HCV infection and the manifestation of OLP (Chi-square test −46.852, p = 7.65 × 10–12). None of the individuals in OLP-positive group had HCV infection. The most common systemic diseases were hypertension and diabetes, and the most commonly used drugs were antihypertensives. However, there was no significant relationship between these factors and the presence of OLP or HCV infection (p > 0.05).

Conclusion

There was a significant relationship between HCV infection and manifestation of OLP. Age, sex, systemic diseases and drugs were not identified as risk factors for the development of these diseases.

Clinical significance

The OLP could serve as an indicative of HCV infection in asymptomatic patients, thus enabling early diagnosis and treatment of hepatitis and hence, a better prognosis.

How to cite this article

De Carli JP, Linden MSS, da Silva SO, Trentin MS, Matos FS, Paranhos LR. Hepatitis C and Oral Lichen Planus: Evaluation of their Correlation and Risk Factors in a Longitudinal Clinical Study. J Contemp Dent Pract 2016;17(1):27-31.

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  1. Oral mucosal conditions in chronic hepatitis C Brazilian patients: a cross-sectional study. J Public Health Dent 2009 Summer;69(3):168-175.
  2. Hepatitis C virus and lichen planus. J Gastroenterol Hepatol 2004;19(10):1101-1113.
  3. Lichen planus and hepatitis C: a literature review. Rev Clín Pesq Odontol 2005;1(3):37-40.
  4. A study on the association with hepatitis B and hepatitis C in 1557 patients with lichen planus. J Eur Acad Dermatol Venereol 2010 Apr;25(4):436-440.
  5. Bilateral linear lichen planus pigmentosus associated with hepatitis C virus infection. Case Rep Dermatol 2010 Sep 11;2(3):169-172.
  6. Erosive lichen planus and cirrhotic hepatitis. Ital Gen Rev Dermatol 1978 May-Aug;15(2):123-131.
  7. Hepatitis C virus and lichen planus: a review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;98(2):171-183.
  8. Oral lichen planus and chronic hepatitis C: a controversial association. Am J Clin Pathol 2007 May;127(5):800-804.
  9. A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain. J Oral Pathol Med 2010 Jul;39(6):491-496.
  10. Oral diseases associated with hepatitis C virus infection. Part2: lichen planus and other diseases. Oral Dis 2008 Apr;14(3):217-228.
  11. Lichen planus and hepatite C virus: a multicentre study of patients with oral lesions and a systematic review. Br J Dermatol 2004 Dec;151(6):1172-1181.
  12. Oral lichen planus: a review. Minerva Stomatol 2009 Oct;58(10):519-537.
  13. The clinical features, malignant potential, and systemic association of oral lichen planus: a study of 723 patients. J Am Acad Dermatol 2002 Feb;46(2):207-214.
  14. Glucose tolerance in lichen planus. Br J Dermatol 1974 Jul;91(1):73-75.
  15. Carbohydrate metabolism in lichen planus. Br J Dermatol 1976 Jul;95(1):9-12.
  16. A clinical study of 674 patients with oral lichen planus in China. J Oral Pathol Med 2005 Sep;34(8):467-472.
  17. The medication of patients with oral lichen planus and the association of nonsteroidal anti-inflammatory drugs with erosive lesions. Oral Surg Oral Med Oral Pathol 1987 Nov;64(5):541-543.
  18. Drug-induced lichen planus. Pharmacotherapy 1994 Sep-Oct;14(5):561-571.
  19. Captopril-induced lichen planus pemphigoides. Pharmacoepidemiol Drug Saf 2008 Jul;17(7):722-724.
  20. Oral lichen planus: the evidence regarding potential malignant transformation. J Oral Pathol Med 1978 Feb;7:1-7.
  21. Lack of clinicopathological correlation in the diagnosis of oral lichen planus based on the presently available criteria and suggestion for modification. J Oral Pathol Med 2003 Oct;32:507-512.
  22. Lichen planus and hepatitis C virus in the northern Kyushu region of Japan. Eur J Clin Invest 1995 Dec;25(12):910-914.
  23. Hepatitis C virus infection in Italian patients with oral lichen planus: a prospective case-control study. J Oral Pathol Med 1996 Nov;25(10):527-533.
  24. Oral lichen planus and hepatitis C virus infection. Oral Dis 2002 Jan;8(1):42-46.
  25. Hepatitis C virus infection and oral lichen planus: a report from the Netherlands. J Oral Pathol Med 2000 Jul;29(6):255-258.
  26. Oral lichen planus in patients with chronic liver diseases. Infection 2003 Dec;31(6):383-386.
  27. Lack of evidence of hepatic disease in patients with oral lichen planus in Serbia. Oral Dis 2004 Sep;10(5):283-286.
  28. Prevalence of oral lichen planus in Brazilian patients with HCV infection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005 Sep;100(3):330-333.
  29. Oral manifestations of hepatitis C virus infection. World J Gastroenterol 2014 Jun 28;20(24):7534-7543.
  30. Course of oral lichen planus: a retrospective study of 808 northern Italian patients. Oral Dis 2009 Apr;15(3):235-243.
  31. Surveillance Secretariat of Health STD, AIDS and Viral Hepatitis. Epidemiological Bulletin: Viral Hepatitis. 2010, 96 p. Available at: http://www.aids.gov.br/sites/default/files/manual_abcde_28_09_a2.pdf
  32. Predictive factors for adverse dermatological events during pegylated/interferon alpha and ribavirin treatment for hepatitis C. J Clin Virol 2014 Jul;60(3):190-195.
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