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VOLUME 17 , ISSUE 6 ( June, 2016 ) > List of Articles


Assessment of the Influence of Meal Type on Fluoride Absorption due to Ingestion of professionally Applied Gels

Andreany M Cavalli, Adriana G Rebouças, Luciane Zanin, Flávia M Flório

Citation Information : Cavalli AM, Rebouças AG, Zanin L, Flório FM. Assessment of the Influence of Meal Type on Fluoride Absorption due to Ingestion of professionally Applied Gels. J Contemp Dent Pract 2016; 17 (6):451-456.

DOI: 10.5005/jp-journals-10024-1871

Published Online: 01-10-2016

Copyright Statement:  Copyright © 2016; The Author(s).



The aim of this study is to assess the influence of eating, prior to application of professionally used gels, on the rate of fluoride absorption due to the ingestion of 1.23% acidulated phosphate fluoride (APF).

Materials and methods

After fasting for 12 hours, 16 adult volunteers (> 65 kg) ingested two types of meal: Breakfast (n = 8) and Lunch (n = 8). Accidental ingestion of fluoride gel used in molding trays was simulated (12,300 ppm; 61.5 mg F; pH = 4.65) 15 minutes after eating. After ingestion of the fluoride solution, 3 mL of venous blood were collected at the following times: Zero (before ingestion) and 15, 30, 45 minutes, 1, 2, and 3 hours. Fluoride concentrations in blood plasma were determined using an ion selective electrode.


With the exception of time 0 (p > 0.05), the average blood plasma concentration of the breakfast group (BG) (0.34 ± 0.04 mg/L) was higher than that of the lunch group (LG) (0.24 ± 0.03 mg/L), with the moment of peak concentration being 2 hours after ingestion for both groups (BG = 0.4 mg/L; LG = 0.28 mg/L).


Results reinforce the idea that eating before undergoing professional application of fluoride is a factor of extreme importance regarding its safety, and that the time following a patient's heaviest meal should be the time of choice for planning clinical care.

Clinical significance

Our results should be considered when planning collective action that involves the application of the gel on children in a school environment, thus ensuring the procedure's safety.

How to cite this article

Cavalli AM, Rebouças AG, Zanin L, Flório FM. Assessment of the Influence of Meal Type on Fluoride Absorption due to Ingestion of professionally Applied Gels. J Contemp Dent Pract 2016;17(6):451-456.

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