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VOLUME 17 , ISSUE 7 ( July, 2016 ) > List of Articles

RESEARCH ARTICLE

Oral Leukoplakia: Clinicopathological Correlation and Its Relevance to Regional Tobacco-related Habit Index

Prashanth Shetty, Shweta Hegde, KS Vinod, Salona Kalra, Prasoon Goyal, Mimansha Patel

Citation Information : Shetty P, Hegde S, Vinod K, Kalra S, Goyal P, Patel M. Oral Leukoplakia: Clinicopathological Correlation and Its Relevance to Regional Tobacco-related Habit Index. J Contemp Dent Pract 2016; 17 (7):601-608.

DOI: 10.5005/jp-journals-10024-1897

Published Online: 01-07-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction

A case control study was carried out to evaluate the synergistic effects of habits quantified by habit index and its effect and severity on the clinicopathological features of oral leukoplakia in a cohort of 100 patients visiting Triveni Dental College, Bilaspur, Chhattisgarh, India.

Materials and methods

One hundred patients indulging in tobacco-related habits (smoking and smokeless forms) were categorized into two groups: A case/experimental group consisting of 50 patients presenting with oral leukoplakia lesion and a control group consisting of 50 patients with no clinical signs of oral leukoplakia. Habit index was calculated in both groups. Case group was further subjected to incisional biopsy of the lesion followed by histopathological examination. All the variables in the study were statistically analyzed for the mean, standard deviation, i.e., value of central tendency, z-test, test of significance, and Pearson's correlation (r-test).

Results

For p < 0.05 bidi habit index was significantly higher in the case group. Higher bidi habit index was evident in the severe stages of lesion ice, p < 0.001 (highly significant). The degree of dysplasia was higher with advancing clinical stage of the lesion.

Conclusion

Higher bidi habit index in the case group contributed significantly for severe stages of lesion and thereby indicates its probable progression toward malignancy. Nonhomogenous leukoplakia of the speckled subtype exhibited moderate and severe epithelial dysplasia. Hence, quantification of tobacco-related habits and the clinical appearance of the premalignant lesion predict the risk of subsequent malignant transformation of the disease.

How to cite this article

Shetty P, Hegde S, Vinod KS, Kalra S, Goyal P, Patel M. Oral Leukoplakia: Clinicopathological Correlation and Its Relevance to Regional Tobacco-related Habit Index. J Contemp Dent Pract 2016;17(7):601-608.


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