The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 18 , ISSUE 12 ( December, 2017 ) > List of Articles

RESEARCH ARTICLE

Assessment of Proliferative Potential of Odontogenic Keratocyst and Dentigerous Cyst using Podoplanin: An Immunohistochemical Study

Prashant Rao, Aparna Paliwal, Shekhar Grover, Sandeep Gupta, Nidhi Choudaha

Citation Information : Rao P, Paliwal A, Grover S, Gupta S, Choudaha N. Assessment of Proliferative Potential of Odontogenic Keratocyst and Dentigerous Cyst using Podoplanin: An Immunohistochemical Study. J Contemp Dent Pract 2017; 18 (12):1173-1176.

DOI: 10.5005/jp-journals-10024-2194

Published Online: 00-12-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction

Odontogenic cysts are commonly encountered lesions among head and neck pathologies. Odontogenic keratocyst (OKC) has unique features of recurrence and local aggressiveness. Podoplanin (PDP) is a lymphatic endothelial marker and is shown to be expressed in a variety of tissues. Hence, we planned to assess the significance of PDP in OKC and dentigerous cyst (DC).

Materials and methods

The present study included assessment of immunoexpression of PDP in OKC and DC. Twenty specimens each of OKC and DC were included in the present study and were stained with D2-40 antibody. All the sections were analyzed and were categorized as negative staining, weakly positive staining, and strongly positive staining. All the results were analyzed by Statistical Package for the Social Sciences (SPSS) software.

Results

We detected PDP-positive staining in the cell membrane and cytoplasm of the cells of basal cell layer and suprabasal cell layers. In DC cases, we observed positive staining only in cases associated with inflammation.

Conclusion

Podoplanin does play a significant role in enhancing the local invasive and neoplastic properties of OKC.

Clinical significance

Podoplanin expression in OKC is potentially associated with moderate invasive nature of the neighboring structures.

How to cite this article

Gupta S, Paliwal A, Choudaha N, Gupta A, Rao P, Grover S. Assessment of Proliferative Potential of Odontogenic Keratocyst and Dentigerous Cyst using Podoplanin: An Immunohistochemical Study. J Contemp Dent Pract 2017;18(12):1173-1176.


PDF Share
  1. Classification of odontogenic tumours. A historical review. J Oral Pathol Med 2006 Oct;35(9):525-529.
  2. Ein Cholesteatomimlinken Unterkieferuntereinemretinierten weisheitszahn. Zeitsschrift fur Stomatologie 1926;24:40-59.
  3. Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press; 2005.
  4. Origin and growth of cysts of the jaws. Ann R Coll Surg Engl 1967 May;40(5):306-336.
  5. Primordial cysts versus keratocysts. Oral Surg Oral Pathol Oral Med 1975 Sep;40(3):362-364.
  6. Podoplanin: emerging functions in development, the immune system, and cancer. Front Immunol 2012 Sep;3:283.
  7. Podoplanin expression profiles characteristic of odontogenic tumour-specific tissue architectures. Pathol Res Pract 2012 Mar;208(3):140-146.
  8. Tumour invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell 2006 Apr;9(4):261-272.
  9. Significance of podoplanin expression in keratocystic odontogenic tumor. J Oral Pathol Med 2010 Jan;39(1):110-114.
  10. Enhanced expression of aggress (T1&/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma. Tumor Biol 2005 Jul-Aug;26(4):195-200.
  11. Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Int J Cancer 2005 Mar;113(6):899-910.
  12. T1alpha podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J 2003 Jul;22(14):3546-3556.
  13. Podoplanin expression in human tooth germ tissues and cystic odontogenic lesions: an immunohistochemical study. J Oral Pathol Med 2010 Jan;39(1):115-120.
  14. Expression of podoplanin in nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumours. Anticancer Res 2012 May;32(5):2125-2127.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.