Citation Information :
Dash KC, Bandyopadhyay A, Panda A, Ramachandra S, Mishra P. Glucose Transporter 1 Expression in Odontogenic Keratocyst, Dentigerous Cyst, and Ameloblastoma: An Immunohistochemical Study. J Contemp Dent Pract 2017; 18 (5):366-370.
An array of odontogenic lesions manifest in the maxillofacial region with variable presentations. The biological behavior of lesions, such as odontogenic keratocyst (OKC), dentigerous cyst (DC), and ameloblastoma (AM) always invite debate. Glucose transporter 1 (GLUT-1) is proven to be an indicator of metabolic behavior of several benign and malignant neoplasms.
Aim
The purpose of this study was to evaluate the expression of GLUT-1 in OKC, DC, and AM to understand their metabolic behavior.
Materials and methods
Immunohistochemical expression of GLUT-1 was evaluated in each of the 15 cases of OKC, DC, and AM. The number of labeled cells, staining intensity, and membrane or cytoplasmic expressions were the parameters assessed and analyzed using chi-square test.
Results
All cases showed positive GLUT-1 expression: 86.6% OKC showed more than 50% labeled cells followed by DC (40%) and AM (26.5%); 53.3% OKC showed strong intensity in comparison to AM, which showed weak intensity in 53.3% cases; 86.6% of OKCs showed both membrane and cytoplasmic expression followed by DC (40%) and AM (26.6%), whereas 73.3% of AM showed only membrane expression followed by DC (60%) and OKC (13.3%).
Conclusion
Odontogenic keratocyst was found out to be more metabolically active followed by DC and AM.
How to cite this article
Bandyopadhyay A, Panda A, Behura SS, Ramachandra S, Dash KC, Mishra P. Glucose Transporter 1 Expression in Odontogenic Keratocyst, Dentigerous Cyst, and Ameloblastoma: An Immunohistochemical Study. J Contemp Dent Pract 2017;18(5):366-370.
Frequency of odontogenic cysts and tumors: a systematic review. J Investig Clin Dent 2014 Feb;5(1):9-14.
; Speight, P. Odontogenic keratocyst. In: Cysts of the oral and maxillofacial regions. 4th ed. Singapore: Blackwell Munksgaard; 2007. p. 6-58.
Clinical, radiological and therapeutic features of keratocystic odontogenic tumours: a study over a decade. J Clin Exp Dent 2014 Jul;6(3):e259-e264.
Analysis of 153 cases of odontogenic cysts in a South Indian sample population: a retrospective study over a decade. Braz Oral Res 2012 Jun;26(4):330-334.
; Philipsen, HP. Solid multicystic ameloblastoma. In: Odontogenic tumors and allied lesions. 1st ed. London: Quintessence Publishing; 2004. p. 43-58.
Ameloblastoma in the northeast region of Brazil: a review of 112 cases. J Oral Maxillofac Pathol 2014 Sep;18(Suppl 1):S66-S71.
; Eveson, JW.; Reichart, P.; Sidransky, D. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC; 2005.
Glucose transporters in the 21st century. Am J Physiol Endocrinol Metab 2010 Feb;298(2):E141-E145.
Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr 2003 Jan;89(1):3-9.
GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker. Clinics (Sao Paulo) 2011 Jun;66(6):965-972.
Correlation between FDG-PET findings and GLUT1 expression in salivary gland pleomorphic adenomas. Ann Nucl Med 2008 Oct;22(8):693-698.
Expression of Glut-1, HIF-1a, PI3K and p-Akt in a case of ceruminous adenoma. Head Neck Oncol 2012 May;4(1):18.
Expression of GLUT-1 in oral squamous cell carcinoma in tobacco and non-tobacco users. J Oral Biol Craniofac Res 2016 Jan-Apr;6(1):24-30.
Usefulness of 18F-fluorodeoxyglucose positron emission tomography for detecting ameloblastoma, with special reference to glucose transporter-1 expression. J Oral Maxillofac Surg 2008 Aug;66(8):1761-1765.
Immunohistochemical expression of GLUT-1, GLUT-3, and carbonic anhydrase IX in benign odontogenic lesions. J Oral Pathol Med 2016 Oct;45(9):712-717.
Immunohistochemical expression of glucose transporter 1 in keratin-producing odontogenic cysts. BMC Oral Health 2016 Dec;16(1):32.
Expression of inducible nitric oxide synthase in the epithelial linings of odontogenic keratocyst, dentigerous cyst and radicular cyst: a pathological insight. Ann Med Health Sci Res 2014 Jul-Aug;4(4):583-589.
The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 1: clinical and early experimental evidence of aggressive behaviour. Oral Oncol 2002 Apr;38(3):219-226.
Evaluation of Ki-67 and cyclin D1 expression in odontogenic keratocysts and orthokeratinised jaw cysts. SADJ 2012 Aug;67(7):370-373.
Differential expression of cyclin D1 in keratin-producing odontogenic cysts. Med Oral Patol Oral Cir Bucal 2015 Jan;20(1):e59-e65.
Functional properties and genomics of glucose transporters. Curr Genomics 2007 Apr;8(2):113-128.
Coexpression of hypoxia-inducible factor-1a and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients. Histopathology 2011 Mar;58(7):1136-1147.
Facilitative glucose transporter expression in human cancer tissue. Br J Biomed Sci 1999 Feb;56(4):285-292.
GLUT1 and GLUT3 as potential prognostic markers for oral squamous cell carcinoma. Molecules 2010 Apr;15(4):2374-2387.
Immunohistochemical study of GLUT-1 in oral peripheral nerve sheath tumors. Oral Dis 2008 Sep;14(6):510-513.
Immunohistochemical expression of the glucose transporters GLUT-1 and GLUT-3 in human malignant melanomas and benign melanocytic lesions. J Exp Clin Cancer Res 2008 Sep;27(1):34.
Ghost cells in pilomatrixoma, craniopharyngioma, and calcifying cystic odontogenic tumor: histological, immunohistochemical, and ultrastructural study. J Oral Pathol Med 2015 Apr;44(4):284-290.
FDG-PET findings of ameloblastoma: a case report. Springerplus 2015 Jun;4:250.
Immunohistochemical expression of GLUT-1 and HIF-1a in tooth germ, ameloblastoma, and ameloblastic carcinoma. Int J Surg Pathol 2016 Aug;24(5):410-418.
GLUT-1 expression in cutaneous basal and squamous cell carcinomas. Int J Surg Pathol 2015 Sep;23(6):447-453.
GLUT-1 immunoexpression in oral epithelial dysplasia, oral squamous cell carcinoma, and verrucous carcinoma. J Oral Sci 2015 Jun;57(2):115-122.
Glut-1, best immunohistochemical marker for perineurial cells. Head Neck Pathol 2015 Mar;9(1):104-106.