The Journal of Contemporary Dental Practice

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 18 , ISSUE 5 ( May, 2017 ) > List of Articles


Intricate Assessment and Evaluation of Long-term Implant Success as affected by Clinicomicrobial and Salivary Diagnostics in Type II Diabetic Patients: A Longitudinal Study

Fawaz Alqahtani, Zaheer Kola, Deepti Raghav, Fatima J Albaker, Tushar V Bhagat

Citation Information : Alqahtani F, Kola Z, Raghav D, Albaker FJ, Bhagat TV. Intricate Assessment and Evaluation of Long-term Implant Success as affected by Clinicomicrobial and Salivary Diagnostics in Type II Diabetic Patients: A Longitudinal Study. J Contemp Dent Pract 2017; 18 (5):405-409.

DOI: 10.5005/jp-journals-10024-2055

Published Online: 01-09-2017

Copyright Statement:  Copyright © 2017; The Author(s).



Replacement of missing teeth by dental implants is one of the most common methods employed these days. Because of significant advancement in the design of implants and modifications in the procedure of dental implant surgery, the survival rate of the dental implants has reached up to approximately 95%. Osseointegration is one of the important factors affecting the survival of dental implants. Apart from these, the body's physiologic alterations can also predispose the dental implants for failure. Diabetes is one such metabolic disease characterized by abnormal or delayed wound healing. Hence, we assessed the clinicomicrobial and salivary profile of diabetic patients undergoing rehabilitation by dental implants.

Materials and methods

This study included diabetic patients who underwent dental implant surgeries for prosthetic rehabilitation. Follow-up records of the patients’ up to 1 year were maintained. Various clinicoradiographic and periodontal parameters were measured at various time intervals during follow-up time; 25 mL of salivary and blood sample was taken from all the subjects and was sent to the laboratories for assessment of various salivary biomarkers. All the results were analyzed by Statistical Package for the Social Sciences software.


The mean level of interleukin-â at baseline time was found to be 2.38 and 2.21 in diabetic group and control group respectively. While comparing the levels of osteoprotegerin in both study groups, a significant correlation was obtained. In diabetic and control group, 62 and 61 years was the mean age of the patients respectively. No significant correlation was obtained while comparing the microbial flora of diabetic and control group.


In both diabetic and nondiabetic patients, similar microbial, salivary marker, and clinicoradiological patterns were seen.

Clinical significance

Diabetic patients who maintain their body's metabolic rate show similar success rate of dental implants as seen in nondiabetic patients.

How to cite this article

Raghav D, Alqahtani F, Albaker FJ, Bhagat TV, Kola Z. Intricate Assessment and Evaluation of Long-term Implant Success as affected by Clinicomicrobial and Salivary Diagnostics in Type II Diabetic Patients: A Longitudinal Study. J Contemp Dent Pract 2017;18(5):405-409.

PDF Share
  1. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review. Int J Oral Maxillofac Surg 2015 Mar;44(3):377-388.
  2. Periodontal status of diabetics compared with nondiabetics: a meta-analysis. J Diabetes Complications 2006 Jan-Feb;20(1):59-68.
  3. The mechanism of protracted wound healing on oral mucosa in diabetes. Review. Bosn J Basic Med Sci 2010 Aug;10(3):186-191.
  4. Comparison of different data analyses for detecting changes in attachment level. J Clin Periodontol 1983 May;10(3):298-310.
  5. Prevalence of periodontal pathogens in localized and generalized forms of early-onset periodontitis. J Periodontal Res 2000 Aug;35(4):232-241.
  6. Prevalence of diabetes among men and women in China. N Engl J Med 2010 Mar;362(12):1090-1101.
  7. Prevalence of diabetes mellitus in a rural population of Goa, India. Natl Med J India 2011 Jan-Feb;24(1):16-18.
  8. Diabetes atlas. 4th ed. Montreal, Canada: International Diabetes Federation; 2009.
  9. Dental implants for immediate fixed restoration of partially edentulous patients: a 1-year prospective pilot clinical trial in periodontally susceptible patients. J Periodontol 2007 Jul;78(7):1188-1194.
  10. A retrospective evaluation of 1,387 single-tooth implants: a 6-year follow-up. J Periodontol 2006 Dec;77(12):2080-2083.
  11. Success of dental implants placed in intraoral block bone grafts. J Periodontol 2007 Jan;78(1):18-21.
  12. Calcium homeostasis in diabetes mellitus. J Clin Endocrinol Metab 1979 Sep;49(3):462-466.
  13. Peri-implant disease in subjects with and without preventive maintenance: a 5-year follow-up. J Clin Periodontol 2012 Feb;39(2):173-181.
  14. Osteoprotegerin and biomarkers of vascular inflammation in type 2 diabetes. Diabetes Metab Res Rev 2010 Sep;26(6):496-502.
  15. Increased osteoprotegerin serum levels in men with coronary artery disease. J Clin Endocrinol Metab 2003 Mar;88(3):1024-1028.
  16. Clinical course of chronic periodontitis. III. Patterns, variations and risks of attachment loss. J Clin Periodontol 2003 Oct;30(10):909-918.
  17. Intra-oral pattern of tooth and periodontal bone loss between the age of 50 and 60 years. A longitudinal prospective study. Acta Odontol Scand 2004 Aug;62(4):214-222.
  18. Detection of putative periodontal pathogens in non-insulin-dependent diabetes mellitus and non-diabetes mellitus by polymerase chain reaction. J Periodontal Res 2001 Feb;36(1):18-24.
  19. IL-1 gene polymorphism and smoking as risk factors for peri-implant bone loss in a well-maintained population. Clin Oral Implants Res 2003 Feb;14(1):10-17.
  20. Survival analysis of implant in patients with diabetes mellitus: a systematic review. Implant Dent 2016 Oct;25(5):663-674.
  21. Comparison of clinical and radiographic parameters around short (6 to 8 mm in length) and long (11 mm in length) dental implants placed in patients with and without type 2 diabetes mellitus: 3-year follow-up results. Clin Oral Implants Res 2016 Jul 29. doi: 10.1111/clr.12938. [Epub ahead of print]
  22. Does a higher glycemic level lead to a higher rate of dental implant failure? A meta-analysis. J Am Dent Assoc 2016 Nov;147(11):875-881.
  23. Outcome of dental implants in diabetic patients with and without cardiovascular disease: a 5-year post-loading retrospective study. Eur J Oral Implantol 2016 Spring;9(1):87-95.
  24. The effect of smoking on osseointegrated dental implants. Part II: peri-implant bone loss. Int J Prosthodont 2006 Nov-Dec;19(6):560-566.
  25. Impact of type 2 diabetes on the gene expression of bone-related factors at sites receiving dental implants. Int J Oral Maxillofac Surg 2015 Oct;44(10):1302-1308.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.