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VOLUME 19 , ISSUE 1 ( January, 2018 ) > List of Articles

ORIGINAL RESEARCH

Effect of Topical Honey on Mandibular Bone Defect Healing in Rats

Bahman Derakhshan, Farhad Hajizadeh, Zahra Abbasi

Citation Information : Derakhshan B, Hajizadeh F, Abbasi Z. Effect of Topical Honey on Mandibular Bone Defect Healing in Rats. J Contemp Dent Pract 2018; 19 (1):47-51.

DOI: 10.5005/jp-journals-10024-2210

License: CC BY-NC 3.0

Published Online: 01-01-2018


Abstract

pharmacological effects, from wound dressing to anticancerogenic and from anti-inflammatory to antibacterial activities. The aim of the current study was to evaluate the effect of honey on healing of mandibular bone defects in a rat model. Materials and methods: This animal study was performed on 24 wild-type Wistar rats. Following shaving, disinfection, and extraoral incision, a 2 × 2 mm defect was created at mandibular angle. In the experimental group, the defect was filled with sterile honey, while it was left unfilled in the control group. The rats were sacrificed after 2 and 4 weeks and defects were assessed histologically. The results were compared using Mann–Whitney U-test (α = 0.05). Results: After 2 weeks, five samples of the experimental group were in mineralization phase, while all samples of the control group were in the vascularization phase (p = 0.015). After 4 weeks, the defects were filled in four samples of the experimental group, while all samples of the control group were in the mineralization stage (p = 0.002). Histomorphometric assessment revealed that the mean new bone formation in the experimental group was significantly more than the control group, both after 2 and 4 weeks (p = 0.041). Conclusion: The results showed that honey could accentuate bone healing of mandibular small defects in rats. Clinical significance: Honey might have potential in repair of human alveolar bone defects.


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  1. Motamedian SR, Iranparvar P, Nahvi G, Khojasteh A. Bone tissue engineering: a literature review. Regen Reconstr Restor 2016 Apr;1(3):103-120
  2. Success rate of implants placed in autogenous bone blocks versus allogenic bone blocks: a systematic literature review. Ann Maxillofac Surg 2016 Jan-Jun;6(1):78-90
  3. Regenerative medicine in the treatment of alveolar cleft defect: a systematic review of the literature. J Craniomaxillofac Surg 2015 Oct;43(8):1608-1613
  4. Application of selected scaffolds for bone tissue engineering: a systematic review. Oral Maxillofac Surg 2017 Jun;21(2):109-129
  5. Smart scaffolds in bone tissue engineering: a systematic review of literature. World J Stem Cells 2015 Apr;7(3):657-668
  6. Response of dental pulp stem cells to synthetic, allograft, and xenograft bone scaffolds. Int J Periodontics Restorative Dent 2016 Aug
  7. Polymeric vs hydroxyapatite-based scaffolds on dental pulp stem cell proliferation and differentiation. World J Stem Cells 2015 Nov;7(10):1215-1221
  8. Anterior interbody fusion for severe cervical disc degeneration. Surg Gynecol Obstet 1972 May;134(5):755-758
  9. Transplantation of bone. Surg Clin North Am 1978 Apr;58(2):403-427
  10. Principles of bone healing. Neurosurg Focus 2001 Apr;10(4):E1
  11. Bone healing in surgically created defects treated with either bioactive glass particles, a calcium sulfate barrier, or a combination of both materials. A histological and histometric study in rat tibias. Clin Oral Implants Res 2005 Dec;16(6):683-691
  12. Polychrome labeling of bone with seven different fluorochromes: enhancing fluorochrome discrimination by spectral image analysis. Bone 2005 Oct;37(4):441-445
  13. In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects. Acta Biomater 2009 Jun;5(5):1775-1784
  14. Effects of daily consumption of honey solution on hematological indices and blood levels of minerals and enzymes in normal individuals. J Med Food 2003 Summer;6(2):135-140
  15. The safety and efficacy of a mixture of honey, olive oil, and beeswax for the management of hemorrhoids and anal fissure: a pilot study. Sci World J 2006 Feb;6:1998-2005
  16. Bone mechanical properties and mineral density in response to cessation of jumping exercise and honey supplementation in young female rats. Biomed Res Int 2015 Jun;2015:938782
  17. Evaluation of the phenolic contents and antioxidant capacities of two Malaysian floral honeys. Food Chem 2004 May;85(4):513-518
  18. Honey in modern wound care: a systematic review. Burns 2013 Dec;39(8):1514-1525
  19. Effects of honey and its mechanisms of action on the development and progression of cancer. Molecules 2014 Feb;19(2):2497-2522
  20. Anti-inflammatory activity of a honey flavonoid extract on lipopolysaccharide-activated N13 microglial cells. J Agric Food Chem 2012 Dec;60(50):12304-12311
  21. Gelam honey inhibits the production of proinflammatory, mediators NO, PGE(2), TNF-α, and IL-6 in carrageenan-induced acute paw edema in rats. Evid Based Complement Alternat Med 2012 Apr;2012:109636
  22. The antibacterial activity of honey. 1. The nature of the antibacterial activity. Bee World 1992;73(1):5-28
  23. The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey. BMC Complement Altern Med 2009 Sep;9:34
  24. Honey with high levels of antioxidants can provide protection to healthy human subjects. J Agric Food Chem 2003 Mar;51(6):1732-1735
  25. Why do some cavity wounds treated with honey or sugar paste heal without scarring? J Wound Care 2002 Feb;11(2):53-55
  26. Honey a sweet approach to alveolar osteitis: a study. Natl J Maxillofac Surg 2014 Jan;5(1):31-34
  27. Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity. Nutr Res 2010 Sep;30(9):650-659
  28. Protective effects of tualang honey on bone structure in experimental postmenopausal rats. Clinics (Sao Paulo) 2012 Jul;67(7):779-784
  29. Review: evidence on the effectiveness of honey for healing wounds is limited. Evid Based Nurs 2009 Apr;12(2):53
  30. Honey and wound healing: an overview. Am J Clin Dermatol 2011 Jun;12(3):181-190
  31. A review of molecular mechanisms of the anti-leukemic effects of phenolic compounds in honey. Int J Mol Sci 2012 Nov;13(11):15054-15073
  32. Clinical observations on the wound healing properties of honey. Br J Surg 1988 Jul;75(7):679-681
  33. The contribution of catalase and other natural products to the antibacterial activity of honey: a review. Food Chem 2000 Nov;71(2):235-239
  34. The effects of supplemental zinc and honey on wound healing in rats. Iran J Basic Med Sci 2011 Jul;14(4):391-398
  35. Topically applied lactic acid increases spontaneous secretion of vascular endothelial growth factor by human reconstructed epidermis. Br J Dermatol 2001 Jul;145(1):3-9
  36. The insulin-like effect of hydrogen peroxide on pathways of lipid synthesis in rat adipocytes. J Biol Chem 1979 Sep;254(18):9017-9021
  37. A taste of honey. J Paediatr Child Health 2000 Dec;36(6):596-597
  38. Infant botulism in Israel: knowledge enables prompt diagnosis. Isr Med Assoc J 2004 Apr;6(4):249-250
  39. Why honey is effective as a medicine. 2. The scientific explanation of its effects. Bee World 2001;82(1):22-40.
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