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VOLUME 19 , ISSUE 11 ( November, 2018 ) > List of Articles

ORIGINAL ARTICLE

Clinical Impact and Cosmetic Acceptability of Chlorhexidineenriched Toothpaste and Mouthwash Application on Periodontal Disease: A Randomized Clinical Study

Vanessa R Magaz, Bárbara F Llovera, Miriam Martí, Aurora Garre

Keywords : Allantoin, Chlorhexidine, Dexpanthenol, Mouthwash, Periodontal-disease-index, Toothpaste

Citation Information : Magaz VR, Llovera BF, Martí M, Garre A. Clinical Impact and Cosmetic Acceptability of Chlorhexidineenriched Toothpaste and Mouthwash Application on Periodontal Disease: A Randomized Clinical Study. J Contemp Dent Pract 2018; 19 (11):1295-1300.

DOI: 10.5005/jp-journals-10024-2421

License: CC BY-NC 4.0

Published Online: 01-11-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aims: Oral hygiene is key to prevent periodontal disease (PD). The efficacy of chlorhexidine-containing products has been largely proven, often being tooth discoloration an unwanted associated side-effect. Importantly, some differences related to the pharmaceutical presentation of these products have also been reported. This study aimed to evaluate the efficacy of two different pharmaceutical forms [toothpaste (TP) and mouthwash (MW)] of a new product containing chlorhexidine, dexpanthenol, allantoin and bioadhesive excipient (CDAB) (Bexident® Gums Coadjuvant Treatment) on volunteers with PD. Their preferences, acceptability and cosmetic properties, as well as tooth discoloration, were also assessed. Materials and methods: Total 60 subjects showing mildmoderate symptoms of gingivitis were randomly assigned to two different groups: one receiving TP (n = 30) and the other one receiving MW (n = 30). Periodontal disease index (PDI) was used to evaluate clinical signs at baseline (T0) and after 21 days (T21) of daily use of the products. Satisfaction was assessed through the affirmative/negative answers obtained with the visual analog scale (VAS). Results: All participants completed the study. A significant improvement of PDI score after treatment was reported in both groups (T21/T0) (p < 0.001). Thus, gingivitis improved from moderate to negative [increase = 20.0% (TP)/36.7% (MW)] and from mild to negative [increase = 56.7% (TP)/50.0% (MW)]. After treatment, all subjects reported to have healthier and/or less bleeding teeth (TP 9.0/9.4; MW 8.0/8.2) and would recommend the product (TP:100%/MW:96.6%) with no specific preference regarding its presentation. No change of teeth color was observed. Conclusion: Subjects with PD who received oral care with a new formulation of either chlorhexidine-containing TP or MW for 21 days, reported a significant improvement of their symptoms and resolution of the gingivitis with no associated tooth discoloration. Patients did not show a specific preference for any of the pharmaceutical presentations. Clinical significance: This new formulation of a chlorhexidinecontaining product in both TP and MW forms resulted effective for PD treatment and well accepted by the patients.


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