Citation Information :
Singh V, Khare N, Varghese T, Prashant M, Dodani K, Nagpal N. Resistin and Plasma-reactive Oxygen Metabolite Levels in Obese and Nonobese Individuals with Chronic Periodontitis in Response to Nonsurgical Periodontal Therapy. J Contemp Dent Pract 2018; 19 (12):1526-1531.
Aim: To assess and compare the impact of non-surgical periodontal therapy on plasma reactive oxygen metabolites and resistin values in chronic periodontitis obese and non-obese patients.
Materials and methods: Total 200 subjects were included in the present study and were broadly divided into two study groups with 100 patients in each group as follows: group A: Obese patients with chronic periodontitis, group B: Non-obese, normal weight patients with chronic periodontitis. Various following periodontal parameter were calculated at the baseline time and two months after the nonsurgical periodontal therapy. Plasma reactive oxygen metabolite (RM) and serum and GCF resistin levelswere evaluated. Assessment of all the results was done by Statistical Package for Social Sciences (SPSS) software.
Results: Significant results were obtained while doing an intergroup comparison of clinical attachment levels between two study groups. Significant results were obtained while comparing the clinical attachment levels in both the study groups at different time intervals. Significantmki 9 reduction in the RM was seen in Group B subjects in comparison to Group A subjects 2 months after nonsurgical periodontal therapy.
Conclusion: In patients with chronic periodontitis, obesity can be considered as an important factor in the alteration of resistin levels.
Clinical significance: Obese patients should be motivated for reducing weight so that periodontal therapy and other treatment modalities could be carried out more effectively.
Beamonte-Barrientos R, Verhulst S. Plasma reactive oxygen metabolites, and non-enzymatic antioxidant capacity are not affected by an acute increase of metabolic rate in zebra finches. J Comp Physiol B. 2013 Jul;183(5):675-83.
Amarasena N, Ogawa H, Yoshihara A, Hanada N, Miyazaki H. Serum vitamin C-periodontal relationship in communitydwelling elderly Japanese. J Clin Periodontol 2005;32:93-97.
Amaliya, Timmerman MF, Abbas F, Van der Weijden GA, Van Winkelhoff AJ, Winkel EG, et al. Java project on periodontal diseases: The relationship between vitamin C and the severity of periodontitis. J Clin Periodontol 2007;34:299-304.
Panjamurthy K, Manoharan S, Ramachandran CR. Lipid peroxidation and antioxidant status in patients with periodontitis. Cell Mol Biol Lett 2005;10:255-264.
Jamaluddin MS, Weakley SM, Yao Q, Chen C. Resistin: functional roles and therapeutic considerations for cardiovascular disease. British Journal of Pharmacology. 2012;165(3):622-632.
Gerber M, Boettner A, Seidel B, Lammert A, Bar J, Schuster E, et al. Serum resistin levels of obese and lean children and adolescents: biochemical analysis and clinical relevance. J Clin Endocrinol Metab. 2005;90:4503-4509.
Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
Physical status: The use and interpretation of anthropometry. Report of a WHO expert committee. World Health Organ Tech Rep Ser 1995;854:1-452
Alberti KG, Zimmet P, Shaw J. Metabolic syndrome–A new world-wide definition. A Consensus statement from the international diabetes federation. Diabet Med 2006;23:469-480
Suresh S, Mahendra J, Singh G, Pradeep Kumar AR, Thilagar S, Rao N. Effect of nonsurgical periodontal therapy on plasma-reactive oxygen metabolite and gingival crevicular fluid resistin and serum resistin levels in obese and normal weight individuals with chronic periodontitis. J Indian Soc Periodontol 2018;22:310-316
Furugen R, Hayashida H, Yamaguchi N, Yoshihara A, Ogawa H, Miyazaki H, et al. The relationship between periodontal condition and serum levels of resistin and adiponectin in elderly Japanese. J Periodontal Res 2008;43:556-562.
Tamaki N, Tomofuji T, Ekuni D, Yamanaka R, Yamamoto T, Morita M, et al. Short-term effects of non-surgical periodontal treatment on plasma level of reactive oxygen metabolites in patients with chronic periodontitis. J Periodontol 2009;80: 901-906.
Tamaki N, Tomofuji T, Maruyama T, Ekuni D, Yamanaka R, Takeuchi N, et al. Relationship between periodontal condition and plasma reactive oxygen metabolites in patients in the maintenance phase of periodontal treatment. J Periodontol 2008;79:2136-2142.
Nieva-Vazquez A, Pérez-Fuentes R, Torres-Rasgado E, López- López JG, Romero JR. Serum Resistin Levels Are Associated with Adiposity and Insulin Sensitivity in Obese Hispanic Subjects. Metabolic Syndrome and Related Disorders. 2014;12(2):143-148.
McTernan PG, McTernan CL, Chetty R, Jenner K, Fisher FM, Lauer MN.. Increased resistin gene and protein expression in human abdominal adipose tissue. J Clin Endocrinol Metab 2002;87:2407-2410
Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, Ravussin E, et al. Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. J Clin Endocrinol Metab 2004;89: 1844-1848
Vendrell J, Broch M, Vilarrasa N, Molina A, Gómez JM, Gutiérrez C, et al. Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: Relationships in obesity. Obes Res 2004;12:962-971.
Waddington RJ, Moseley R, Embery G. Reactive oxygen species: A potential role in the pathogenesis of periodontal diseases. Oral Dis 2000;6:138-151.
Suvan JE, Petrie A, Nibali L, Darbar U, Rakmanee T, Donos N, et al. Association between overweight/obesity and increased risk of periodontitis. J Clin Periodontol 2015;42:733-739.
Gonçalves TE, Feres M, Zimmermann GS, Faveri M, Figueiredo LC, Braga PG, et al. Effects of scaling and root planing on clinical response and serum levels of adipocytokines in patients with obesity and chronic periodontitis. J Periodontol 2015;86:53-61.
Machida T, Tomofuji T, Ekuni D, Yamane M, Yoneda T, Kawabata Y et al. Longitudinal Relationship between Plasma Reactive Oxygen Metabolites and Periodontal Condition in the Maintenance Phase of Periodontal Treatment. Dis Markers. 2014;2014:41-49.
Patel SP, Raju PA. Gingival crevicular fluid and serum levels of resistin in obese and non-obese subjects with and without periodontitis and association with single nucleotide polymorphism at-420. J Indian Soc Periodontol 2014;18:555-559.
Suresh S1, Mahendra J, Sudhakar U, Pradeep AR, Singh G. Evaluation of plasma reactive oxygen metabolites levels in obese subjects with periodontal disease. Indian J Dent Res. 2016 Mar-Apr;27(2):155-159.