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VOLUME 19 , ISSUE 5 ( 2018 ) > List of Articles


Biomarkers as Independent Predictors of Bone Regeneration around Biomaterials: A Systematic Review of Literature

Sultan Albeshri, Abdulaziz Alblaihess, Abdurahman A Niazy, Sundar Ramalingam, Chalini Sundar, Hamdan S Alghamdi

Keywords : Biomarkers, Biomaterials, Bone regeneration, Systematic review

Citation Information : Albeshri S, Alblaihess A, Niazy AA, Ramalingam S, Sundar C, Alghamdi HS. Biomarkers as Independent Predictors of Bone Regeneration around Biomaterials: A Systematic Review of Literature. J Contemp Dent Pract 2018; 19 (5):605-618.

DOI: 10.5005/jp-journals-10024-2306

License: CC BY-NC 3.0

Published Online: 01-04-2018

Copyright Statement:  Copyright © 2018; The Author(s).


Background: Biomarkers are detected during bone formation and resorption associated with the dynamics of bone metabolism and are gaining importance as preferential indicators of bone healing in comparison with conventional methodologies. Current literature suggests that the usage of bone turnover markers for monitoring bone regeneration in association with biomaterials is limited. Aim: To systematically review literature and evaluate whether bone-biomarkers can independently predict bone regeneration following implantation of various bone biomaterials. Materials and methods: An electronic search was conducted in PubMed (MEDLINE) database from 1980 to January 2017. The articles for systematic review were selected based on formulated inclusion and exclusion criteria Results: Upon database searching, 443 articles were retrieved and thoroughly reviewed based on the inclusion and exclusion criteria. In all, 41 studies were finally included for evaluation out of which 4 were clinical studies and the remaining 37 studies utilized animal models. On further evaluation, 12 studies reported the presence of biomarkers in association with cellular response during bone regeneration around biomaterials. Moreover, biomarkers related to enzyme activity and matrix protein derivatives were enhanced during bone-matrix deposition as reported in 14 studies. Inorganic skeletal matrix biomarkers indicative of bone mineralization showed positive expression in eight studies. Conclusion: Several biomarkers appear to be useful for the assessment of bone regeneration around biomaterials. Although biomarkers are capable of independently predicting bone regeneration, lack of substantial evidence in the literature limits their true clinical utility. Clinical significance: Noninvasive and inexpensive methods of isolating and characterization of biomarkers from cellular and extracellular skeletal matrix during bone regeneration have proven value in evaluating success of bone biomaterials.

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