Keywords :
Bone morphogenic protein 7, Lymphatic metastasis, Squamous cell carcinoma.
Citation Information :
Eshghyar N, Titidej A, Jolehar M. Prognostic New Marker (Bone Morphogenetic Protein 7) in Squamous Cell Carcinoma. J Contemp Dent Pract 2018; 19 (6):675-679.
Aim: Despite advances in the treatment of oral squamous cell carcinoma (OSCC), its prognosis is still poor. Therefore, it is important to identify the prognostic factors. The aim was to investigate the level of bone morphogenetic protein 7 (BMP7) in SCC of tongue and its relationship with some clinicopathologic parameters.
Materials and methods: In this cross-sectional study, 128 patients with primary SCC of tongue were evaluated. Data were extracted and paraffin blocks were retrieved from the archives of Emam Khomeini Hospital, Tehran, and immunohistochemistry staining was done for the detection of marker. Data were analyzed using Statistical Package for the Social Sciences (SPSS) version 16 and through chi-square and logistic regression tests.
Results: The highest level of BMP7 expression was 54% in men (p = 0.044), 70% in the group aged under 45 years (p = 0.001), 68.2% in patients with lymph node metastasis (p < 0.001), and 100% in those with poorly differentiated tumors (p < 0.001). In multivariate analysis, the presence of lymph node metastasis and increased histopathological grade associated with 5.7 fold and 4.3 fold increase in the odds ratio (OR) of BMP7 expression respectively.
Conclusion: Based on the results, there was a significant relationship between BMP7 expression and poor cellular differentiation and lymph node metastasis, so this marker could be a new prognostic marker in oral cancer.
Clinical significance: This new marker could help clinicians to determine the prognosis of oral cancer, so it has an effect on optimal treatment.
Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol 2008 Feb;26(4):612-619.
Patel SC, Carpenter WR, Tyree S, Couch ME, Weissler M, Hackman T, Hayes DN, Shores C, Chera BS. Increasing incidence of oral tongue squamous cell carcinoma in young white women, age 18 to 44 years. J Clin Oncol 2011 Apr;29(11): 1488-1494.
Warnakulasuriya S. Causes of oral cancer–an appraisal of controversies. Br Dent J 2009 Nov;207(10):471-475.
Petersen PE. Oral cancer prevention and control–the approach of the World Health Organization. Oral Oncol 2009 Apr-May;45(4-5):454-460.
Wang B, Zhang S, Yue K, Wang XD. The recurrence and survival of oral squamous cell carcinoma: a report of 275 cases. Chin J Cancer 2013 Nov;32(11):614-618.
Gloeckler Ries, LA.; Kosary, CL.; Hankey, BF.; Miller, BA.; Harras, A.; Edwards, BK.; editors. SEER cancer statistics review, 1973-1994. NIH publication no. 97-2789. Bethesda (MD): National Cancer Institute; 1997. Available from: http:// seer.cancer.gov/csr/.
Zhang P, Zhang Y, Mao L, Zhang Z, Chen W. Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes. Cancer Lett 2009 May;277(2):227-234.
Marocchio LS, Lima J, Sperandio FF, Corrêa L, de Sousa SO. Oral squamous cell carcinoma: an analysis of 1,564 cases showing advances in early detection. J Oral Sci 2010 Jun;52(2): 267-273.
Xu G, Tang S, Yang J, Chen K, Kang J, Zhao G, Feng F, Yang X, Zhao L, Lu Q, et al. BMP7 expression in esophageal squamous cell carcinoma and its potential role in modulating metastasis. Dig Dis Sci 2013 Jul;58(7):1871-1879.
King M, Chatelain K, Farris D, Jensen D, Pickup J, Swapp A, O'Malley S, Kingsley K. Oral squamous cell carcinoma proliferative phenotype is modulated by proanthocyanidins: a potential prevention and treatment alternative for oral cancer. BMC Complement Altern Med 2007 Jun;7(1):22.
Alarmo EL, Rauta J, Kauraniemi P, Karhu R, Kuukasjarvi T, Kallioniemi A. Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer. Genes Chromosomes Cancer 2006 Apr;45(4):411-419.
Megumi K, Ishigami S, Uchikado Y, Kita Y, Okumura H, Matsumoto M, Uenosono Y, Arigami T, Kijima Y, Kitazono M, et al. Clinicopathological significance of BMP7 expression in esophageal squamous cell carcinoma. Ann Surg Oncol 2012 Jun;19(6):2066-2071.
Miyazaki H, Watabe T, Kitamura T, Miyazono K. BMP signals inhibit proliferation and in vivo tumor growth of androgen-insensitive prostate carcinoma cells. Oncogene 2004 Dec;23(58):9326-9335.
Beck SE, Jung BH, Del Rosario E, Gomez J, Carethers JM. BMPinduced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK. Cell Signal 2007 Jul;19(7):1465-1472.
Rothhammer T, Wild PJ, Meyer S, Bataille F, Pauer A, Klinkhammer-Schalke M, Hein R, Hofstaedter F, Bosserhoff AK. Bone morphogenetic protein 7 (BMP7) expression is a potential novel prognostic marker for recurrence in patients with primary melanoma. Cancer Biomark 2007 Feb;3(2):111-117.
Alarmo EL, Kuukasjärvi T, Karhu R, Kallioniemi A. A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. Breast Cancer Res Treat 2007 Jun;103(2):239-246.
Wang S, Chen Q, Simon TC et al. Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy. Kidney Int 2003;63:2037–2049.
Motoyama K, Tanaka F, Kosaka Y, Mimori K, Uetake H, Inoue H, Sugihara K, Mori M. Clinical significance of BMP7 in human colorectal cancer. Ann Surg Oncol 2008 May;15(5): 1530-1537.
Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S. Expression of BMP-7 in human gastric cancer and its clinical significance. Br J Cancer 2011 Feb;104(4):714-718.
Masuda H, Fukabori Y, Nakano K, Takezawa Y, csuzuki T, Yamanaka H. Increased expression of bone morphogenetic protein-7 in bone metastatic prostate cancer. Prostate 2003 Mar;54(4):268-274.
Miyazono K, Kusanagi K, Inoue H. Divergence and convergence of TGF-beta/BMP signaling. J Cell Physiol 2001 Jun;187(3):265-276.
Thawani JP, Wang AC, Than KD, Lin CY, La Marca F, Park P. Bone morphogenetic proteins and cancer: review of the literature. Neurosurgery 2010 Feb;66(2):233-246.
Yang YM, Lee J, Kim YI, Cho BH, Park SB. Axial cervical vertebrae-based multivariate regression model for the estimation of skeletal-maturation status. Orthod Craniofac Res 2014 Aug;17(3):187-196.
Proffit, WR.; Fields, HW.; Sarver, DM. Contemporary orthodontics. St. Louis (MO): Mosby; 2012.
Singh IJ, Savara BS. Norms of size and annual increments of seven anatomical measures of maxillae in girls from three to sixteen years of age. Angle Orthod 1966 Oct;36(4):312-324.
Perinetti G, Sbardella V, Contardo L. Diagnostic reliability of the third finger middle phalanx maturation (MPM) method in the identification of the mandibular growth peak. Eur J Orthod 2016 Sep;39(2):194-201.
Patil AA, Revankar AV. Reliability of the frontal sinus index as a maturity indicator. Indian J Dent Res 2013 Jul-Aug;24(4):523.
Hegde G, Hegde N, Kumar A, Keshavaraj. A new system for assessment of growth using mandibular canine calcification stages and its correlation with modified MP3 stages. J Pharm Bioallied Sci 2014 Jul;6(Suppl 1):S58-S63.
Surendran S, Thomas E. Tooth mineralization stages as a diagnostic tool for assessment of skeletal maturity. Am J Orthod Dentofacial Orthop 2014 Jan;145(1):7-14.
Hagg U, Taranger J. Maturation indicators and the pubertal growth spurt. Am J Orthod 1982 Oct;82(4):299-309.
Uysal T, Sari Z, Ramoglu S, Basciftci F. Relationships between dental and skeletal maturity in Turkish subjects. Angle Orthod 2004 Oct;74(5):657-664.
O'Reilly MT, Yanniello GJ. Mandibular growth changes and maturation of cervical vertebrae—a longitudinal cephalometric study. Angle Orthod 1988 Apr;58(2):179-184.
Greulich, WW.; Pyle, SI. Radiographic atlas of skeletal development of the hand and wrist. 2nd ed. Stanford (CA): Stanford University Press; 1959.
Mito T, Sato K, Mitani H. Cervical vertebral bone age in girls. Am J Orthod Dentofacial Orthop 2002 Oct;122(4):380-385.
Chen F, Terada K, Hanada K. A new method of predicting mandibular length increment on the basis of cervical vertebrae. Angle Orthod 2004 Oct;74(5):630-634.
Byun, BR.; Kim, YI.; Yamaguchi, T.; Maki, K.; Son, WS. Quantitative assessment of cervical vertebral maturation using cone beam computed tomography in Korean girls. Comput Math Methods Med 2015 Mar;2015:1-9.
Choi YK, Kim J, Yamaguchi T, Maki K, Ko C, Kim Y. Cervical vertebral body's volume as a new parameter for predicting the skeletal maturation stages. Biomed Res 2016 May;2016:1-7.
Crawford B, Kim DG, Moon ES, Johnson E, Fields HW, Palomo JM, Johnston WM. Cervical vertebral bone mineral density changes in adolescents during orthodontic treatment. Am J Orthod Dentofacial Orthop 2014 Aug;146(2):183-189.
Altan M, Nebioðlu Dalci Ö, Ýseri H. Growth of the cervical vertebrae in girls from 8 to 17 years. A longitudinal study. Eur J Orthod. 2012 Jun;34(3):327-34.
Lamparski, DJ. Skeletal age assessment utilizing cervical vertebrae [Ph.D. thesis]. Pittsburgh (PA): University of Pittsburgh; 1972.
Byun BR, Kim YI, Yamaguchi T, Maki K, Ko CC, Hwang DS, Park SB, Son WS. Quantitative skeletal maturation estimation using cone-beam computed tomography-generated cervical vertebral images: a pilot study in 5- to 18-year-old Japanese children. Clin Oral Investig 2015 Nov;19(8):2133-2140.
Smits. The energy body in yoga – Ekhart Yoga. 2015 (cited 2017 Apr 22). Available from: https://www.ekhartyoga. com/blog/the-energy-body-in-yoga.
Rshikesan P, Subramanya P, Singh D, et al. Sleep quality and body composition variations in obese male adults after 14 weeks of yoga intervention: A randomized controlled trial. Int J Yoga2017;10(3):128.
Ebrahimi M, Guilan-Nejad TN, Pordanjani AF, et al. Effect of yoga and aerobics exercise on sleep quality in women with Type 2 diabetes: a randomized controlled trial. Sleep Sci 2017;10(2):68-72.
Halpern J, Cohen M, Kennedy G, Reece J, Cahan C, Baharav A, et al. Yoga for improving sleep quality and quality of life for older adults. Altern Ther Health Med 2014;20(3):37–46.
Rao M, Metri KG, Nagarathna R, Nagendra H, et al. Effects of Mind Sound Resonance Technique (Yogic Relaxation) on Psychological States, Sleep Quality, and Cognitive Functions in Female Teachers: A Randomized, Controlled Trial. Adv Mind Body Med 2017;31(1):4-9.
Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ, et al. The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. psychiatry Res. 1989;28(2):193-213.
Cohen S, Kamarck T, Mermelstein R, et al. A Global Measure of Perceived Stress. J Health Soc Behav 1983;24(4):385-96.
World Health Organization. WHOQOL-BREF: introduction, administration, scoring and generic version of the assessment: field trial version, december 1996. Geneva; 1996.
Deshpande S, Nagendra HR, Raghuram N, et al. A randomized control trial of the effect of yoga on Gunas (personality) and Health in normal healthy volunteers. Int J Yoga 2008 Jan;1(1):2-10.
Patra S, Telles S, et al. Positive impact of cyclic meditation on subsequent sleep. Med Sci Monit 2009 Jul;15(7):CR375-81.
Hegde A, Metri K, Chwadhary P, Babu N, Nagendra HR, et al. Effects of yoga on cardiac health sleep quality, mental health and quality of life of elderly individuals with chronic ailments. Voice Res. 2017;6(1):1-5.
Splinter MY. Rotigotine: transdermal dopamine agonist treatment of Parkinson's disease and restless legs syndrome. Ann Pharmacother 2007 Feb;41(2):285-295.
Iranzo A, Molinuevo JL, Santamaría J, Serradell M, Martí MJ, Valldeoriola F, Tolosa E. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurol 2006 Jul;5(7):572-577.
Howell MJ, Schenck CH. Rapid eye movement sleep behavior disorder and neurodegenerative disease. JAMA Neurol 2015 Jun;72(6):707-712.
Sixel-Döring F, Trautmann E, Mollenhauer B, Trenkwalder C. Rapid eye movement sleep behavioral events: a new marker for neurodegeneration in early Parkinson disease? Sleep 2014 Mar;37(3):431-438.
Vibha D, Shukla G, Goyal V, Singh S, Srivastava AK, Behari M. RBD in Parkinson's disease: a clinical case control study from North India. Clin Neurol Neurosurg 2011 Jul;113(6):472-476.
Vibha D, Shukla G, Singh S, Goyal V, Srivastava AK, Behari M. Lower prevalence of sleep disturbances in familial versus sporadic Parkinson's disease: a questionnaire based study. J Neurol Sci 2010 Aug;295(1-2):27-30.
Abu Alhaija ES, Al-Nimri KS, Al-Khateeb SN. Self perception of malocclusion among Jordanian school children. Eur J Orthod 2005 Jun;27(3):292-295.
Kolawole KA, Otuyemi DE, Jebode SO, Unweni AA. Awareness for malocclusion and desire for orthodontic treatment need in 11-14year old Nigerian school and their parents. Aust Orthod J 2008 May;24(1):21-25.
Cucalon A 3rd, Smith RJ. Relationship between by adolescent orthodontics patients and performance on psychological tests. Angle Orthod 1990 Summer;60(2):107-114.
Southard KA, Tolley EA, Arheart KL, Hackett-Renner CA, Southard TE. Application of the Millon Adolescent Personality Inventory in evaluating orthodontic compliance. Am J Orthod Dentofacial Orthop 1991 Dec;100(6):553-561.
Kharbanda OP. What is the prevalence of malocclusion in India? Do we know orthodontic treatment needs of our country. J Indian Orthod Soc 1999 Apr-Jun;32(2):33-41.
Siddiqui TA, Shaikh A, Fida M. Agreement between orthodontist and patient perception using Index of Orthodontic Treatment Need. Saudi Dent J 2014 Oct;26(4):156-165.
Borzabadi-Farahani A, Borzabadi-Farahani A, Eslamipour F. Orthodontic treatment needs in an urban Iranian population in epidemiological study of 11-14 years old children. Eur J Paediatr Dent 2009 Jun;10(2):69-74.
Grando G, Young AA, Vedovello Filho M, Vedovello SA, Ramirez-Yañez GO. Prevalence of malocclusions in a young Brazilian population. Int J Orthod Milwaukee 2008 Summer;19(2):13-16.
Nadim R, Aslam K, Rizwan S. Frequency of malocclusion among 12 -15 years old school children in three sectors of Karachi. Pak Oral Dent J 2014 Sep;34(3):510-514.
Reddy ER, Manjula M, Sreelakshmi N, Rani ST, Aduri R, Patil BD. Prevalence of malocclusion among 6 to 10 year old Nalgonda school children. J Int Oral Health 2013 Dec;5(6): 49-54.
Onyeaso CO. Prevalence of malocclusion among adolescents in Ibadan, Nigeria. Am J Orthod Dentofacial Orthop 2004 Nov;126(5):604-607.
Kaur H, Pavithra US, Abraham R. Prevalence of malocclusion among adolescents in South Indian population. J Int Soc Prev Community Dent 2013 Jul-Dec;3(2):97-102.
Lauc T. Orofacial analysis on the Adriatic islands: an epidemiological study of malocclusions on Hvar Island. Eur J Orthod 2003 Jun;25(3):273-278.
Zimmermann E, Gamborg M, Holst C, Baker JL, Sørensen TI, Berentzen TL. Body mass index in school-aged children and the risk of routinely diagnosed non-alcoholic fatty liver disease in adulthood: a prospective study based on the Copenhagen School Health Records Register. BMJ Open 2015 May;5(4):e006998.
Reece EA, Hagay Z, Roberts AB, DeGennaro N, Homko CJ, Connolly-Diamond M, Sherwin R, Tamborlane WV, Diamond MP. Fetal Doppler and behavioral responses during hypoglycemia induced with the insulin clamp technique in pregnant diabetic women. Am J Obstet Gynecol 1995 Jan;172(1 Pt 1):151-155.
Patrick J, Campbell K, Carmichael L, Natale R, Richardson B. Patterns of gross fetal body movements over 24-hour observation intervals during the last 10 weeks of pregnancy. Am J Obstet Gynecol 1982 Feb;142(4):363-371.
Ornoy A, Ratzon N, Greenbaum C, Peretz E, Soriano D, Dulitzky M. Neurobehavior of school age children born to diabetic mothers. Arch Dis Child Fetal Neonatal Ed 1998 Sep;79(2):F94-F99.
Wolf, A. Developmental evaluation on early school age children born to gestational diabetic mothers. Israel: Hebrew University; 1997.
Mulder EJ, Leiblum DM, Visser GH. Fetal breathing movements in late diabetic pregnancy: relationship to fetal heart rate patterns and Braxton Hicks’ contractions. Early Hum Dev 1995 Nov;43(3):225-232.
Schulte FJ, Michaelis R, Nolte R, Albert G, Parl U, Lasson U. Brain and behavioral maturation in newborn infants of diabetic mothers. I. Nerve conduction and EEG patterns. Neuropadiatrie 1969 Jan-Jul;1(1):24-35.
Devoe LD, Youssef AA, Castillo RA, Croom CS. Fetal biophysical activities in third-trimester pregnancies complicated by diabetes mellitus. Am J Obstet Gynecol 1994 Aug;171(2):298-303.
Dierker LJ Jr, Pillay S, Sorokin Y, Rosen MG. The change in fetal activity periods in diabetic and nondiabetic pregnancies. Am J Obstet Gynecol 1982 May;143(2):181-185.
Doherty NN, Hepper PG. Habituation in fetuses of diabetic mothers. Early Hum Dev 2000 Aug;59(2):85-93.
Kainer F, Prechtl HF, Engele H, Einspieler C. Assessment of the quality of general movements in fetuses and infants of women with type-1 diabetes mellitus. Early Hum Dev 1997 Nov;50(1):13-25.
Mulder EJ, O'Brien MJ, Lems YL, Visser GH, Prechtl HF. Body and breathing movements in near-term fetuses and newborn infants of type-1 diabetic women. Early Hum Dev 1990 Nov;24(2):131-152.
Mulder EJ, Visser GH. Growth and motor development in fetuses of women with type-1 diabetes. I. Early growth patterns. Early Hum Dev 1991 May;25(2):91-106.
Mulder EJ, Visser GH. Growth and motor development in fetuses of women with type-1 diabetes. II. Emergence of specific movement patterns. Early Hum Dev 1991 May;25(2):107-115.
Mulder EJ, Visser GH. Impact of early growth delay on subsequent fetal growth and functional development: a study on diabetic pregnancy. Early Hum Dev 1992 Dec;31(2):91-95.
Mulder EJ, Visser GH, Bekedam DJ, Prechtl HF. Emergence of behavioral states in fetuses of type-1 diabetic women. Early Hum Dev 1987 Jul;15(4):231-251.
Mulder EJ, Visser GH, Morssink LP, de Vries JI. Growth and motor development in fetuses of women with type-1 diabetes. III. First trimester quantity of fetal movement patterns. Early Hum Dev 1991 May;25(2):117-133.
Aberg A, Westbom L, Kallen B. Congenital malformations among infants whose mothers had gestational diabetes or preexisting diabetes. Early Hum Dev 2001 Mar;61(2):85-95.
Deregnier RA, Nelson CA, Thomas KM, Wewerka S, Georgieff MK. Neurophysiologic evaluation of auditory recognition memory in healthy newborn infants and infants of diabetic mothers. J Pediatr 2000 Dec;137(6):777-784.
Nelson CA, Wewerka S, Thomas KM, Tribby-Walbridge S, deRegnier R, Georgieff M. Neurocognitive sequelae of infants of diabetic mothers. Behav Neurosci 2000 Oct;114(5):950-956.
Reece EA, Homko CJ. Infant of the diabetic mother. Semin Perinatol 1994 Oct;18(5):459-469.
Reece EA, Homko CJ. Why do diabetic women deliver malformed infants? Clin Obstet Gynecol 2000 Mar;43(1):32-45.
Rizzo T, Metzger BE, Burns WJ, Burns K. Correlations between antepartum maternal metabolism and intelligence of offspring. N Engl J Med 1991 Sep;325(13):911-916.
Rizzo TA, Metzger BE, Dooley SL, Cho NH. Early malnutrition and child neurobehavioral development: insights from the study of children of diabetic mothers. Child Dev 1997 Feb;68(1):26-38.
Schwartz R, Teramo KA. Effects of diabetic pregnancy on the fetus and newborn. Semin Perinatol 2000 Apr;24(2):120-135.
Vaarasmaki MS, Hartikainen A, Anttila M, Pramila S, Koivisto M. Factors predicting peri- and neonatal outcome in diabetic pregnancy. Early Hum Dev 2000 Jul;59(1):61-70.
Robertson SS, Dierker LJ. Fetal cyclic motor activity in diabetic pregnancies: sensitivity to maternal blood glucose. Dev Psychobiol 2003 Jan;42(1):9-16.
Accardo PJ, Blondis TA, Whitman BY. Disorders of attention and activity level in a referral population. Pediatrics 1990 Mar;85(3 Pt 2):426-431.
Ornoy A, Uriel L, Tennenbaum A. Inattention, hyperactivity and speech delay at 2-4 years of age as a predictor for ADDADHD syndrome. Isr J Psychiatry Relat Sci 1993;30(3):155-163.
Smyth TR. Impaired motor skill (clumsiness) in otherwise normal children: a review. Child Care Health Dev 1992 Sep-Oct;18(5):283-300.
Petersen MB, Pedersen SA, Greisen G, Pedersen JF, Mølsted- Pedersen L. Early growth delay in diabetic pregnancy: relation to psychomotor development at age 4. Br Med J (Clin Res Ed) 1988 Feb;296(6622):598-600.
Sells CJ, Robinson NM, Brown Z, Knopp RH. Long-term developmental follow-up of infants of diabetic mothers. J Pediatr 1994 Jul;125(1):S9-S17.
Vladareanu R, Lebit D, Constantinescu S. Ultrasound assessment of fetal neurobehaviour in high risk pregnancies. DSJUOG 2012 Apr-Jun;6(2):132-147.
Talic A, Kurjak A, Ahmed B, Stanojevic M, Predojevic M, Kadic AS, Di Renzo GC. The potential of 4D sonography in the assessment of fetal behavior in high-risk pregnancies. J Matern Fetal Neonatal Med 2011 Jul;24(7):948-954.
Bekedam DJ, Visser GH, de Vries JJ, Prechtl HF. Motor behaviour in the growth retarded fetus. Early Hum Dev 1985 Nov;12(2):155-165.
Cioni G, Prechtl HF. Preterm and early postterm motor behaviour in low-risk premature infants. Early Hum Dev 1990 Sep;23(3):159-191.
Seme-Ciglenecki P. Predictive value of assessment of general movements for neurological development of highrisk preterm infants: comparative study. Croat Med J 2003 Dec;44(6):721-727.
Abo-Yaqoub S, Kurjak A, Mohammed AB, Shadad A, Abdel-Maaboud M. The role of 4-D ultrasonography in prenatal assessment of fetal neurobehaviour and prediction of neurological outcome. J Matern Fetal Neonatal Med 2012 Mar;25(3):231-236.
Athanasiadis AP, Mikos T, Tambakoudis GP, Theodoridis TD, Papastergiou M, Assimakopoulos E, Tarlatzis BC. Neurodevelopmental fetal assessment using KANET scoring system in low and high-risk pregnancies. J Matern Fetal Neonatal Med 2013 Mar;26(4):363-368.
Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, Carmina E, Chang J, Yildiz BO, Laven JS, et al. Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 2012 Jan;97(1):28-38.e25
Sirmans SM, Pate KA. Epidemiology, diagnosis and management of polycystic ovary syndrome. Clin Epidemiol 2014; 6:1-13.
Fauser BC, Diedrich K, Bouchard P, Domínguez F, Matzuk M, Franks S, Hamamah S, Simón C, Devroey P, Ezcurra D, et al. Contemporary genetic technologies and female reproduction. Human Reproduction Update 2011 Nov;17(6):829-847.
Balen A, Conway G, Kaltsas G. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod 1995 Aug;10(8):2107-2111.
Azziz R, Sanchez L, Knochenhauer ES, Moran C, Lazenby J, Stephens KC, Taylor K, Boots LR. Androgen excess in women: experience with over 1000 consecutive patients. J Clin Endocrinol Metab 2004 Feb;89(2):453-462.
Wild S, Pierpoint T, McKeigue P, Jacobs H. Cardiovascular disease in women with polycystic ovary syndrome at longterm follow-up: a retrospective cohort study. Clin Endocrinol (Oxf) 2000 May;52(5):595-600.
Hollinrake E, Abreu A, Maifeld M, Van Voorhis BJ, Dokras A. Increased risk of depressive disorders in women with polycystic ovary syndrome. Fertil Steril 2007 Jun;87(6): 1369-1376.
Zawadski JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome. In: Givens JHF, Merriman G, editors. The polycystic ovary syndrome. Cambridge, MA: Blackwell Scientific; 1992. p. 377-384.
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004 Jan;81(1):19-25.
Azziz R, Carmina E, DeWailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, et al. Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab 2006 Nov;91(11):4237-4245.
Lujan ME, Jarrett BY, Brooks ED, Reines JK, Peppin AK, Muhn N, Haider E, Pierson RA, Chizen DR. Updated ultrasound criteria for polycystic ovary syndrome: reliable thresholds for elevated follicle population and ovarian volume. Hum Reprod 2013 May;28(5):1361-1368.
Badawy A, Elnashar A. Treatment options for polycystic ovary syndrome. Int J Womens Health 2011 Feb;3:25-35.
ACOG Committee on Practice Bulletins—Gynecology. ACOG Practice Bulletin No 108: Polycystic ovary syndrome. Obstet Gynecol 2009 Oct;114(4):936-949.
Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Consensus on infertility treatment related to polycystic ovary syndrome. Fertil Steril 2008 Mar;89(3): 505-522.
Balen AH. Ovulation induction in the management of anovulatory polycystic ovary syndrome. Mol Cell Endocrinol 2013 Jul;373(1-2):77-82.
Berridge DL, Winter TC. Saline infusion sonohysterography: technique, indications, and imaging findings. J Ultrasound Med 2004 Jan;23(1):97-112.
Allison SJ, Horrow MM, Kim HY, Lev-Toaff AS. Salineinfused sonohysterography: tips for achieving greater success. Radiographics 2011 Nov-Dec;31(7):1991-2004.
O'Neill MJ. Sonohysterography. Radiol Clin North Am 2003 Jul;41(4):781-797.
Bonnamy L, Marret H, Perrotin F, Body G, Berger C, Lansac J. Sonohysterography: a prospective survey of results and complications in 81 patients. Eur J Obstet Gynecol Reprod Biol 2002 Apr;102(1):42-47.
Lindheim SR, Adsuar N, Kushner DM, Pritts EA, Olive DL. Sonohysterography: a valuable tool in evaluating the female pelvis. Obstet Gynecol Surv 2003 Nov;58(11):770-784.
Lindheim SR, Sprague C, Winter TC. Hysterosalpingography and sonohysterography: lessons in technique. AJR Am J Roentgenol 2006 Jan;186(1):24-29.
Jeanty P, Besnard S, Arnold A, Turner C, Crum P. Air-contrast sonohysterography as a first step assessment of tubal patency. J Ultrasound Med 2000 Aug;19(8):519-527.