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VOLUME 19 , ISSUE 9 ( 2018 ) > List of Articles

ORIGINAL RESEARCH

Role of E-cadherin in Progression of Oral Squamous Cell Carcinoma: A Retrospective Immunohistochemical Study

Awadhesh Gupta, Mohammed Abidullah, Swathi Bhuvinder, Padmavathi Katragadda

Keywords : Cell adhesion molecules, Dysplastic epithelium, E-cadherin, Immunohistochemistry, Tumor markers

Citation Information : Gupta A, Abidullah M, Bhuvinder S, Katragadda P. Role of E-cadherin in Progression of Oral Squamous Cell Carcinoma: A Retrospective Immunohistochemical Study. J Contemp Dent Pract 2018; 19 (9):1105-1110.

DOI: 10.5005/jp-journals-10024-2389

License: CC BY-NC 3.0

Published Online: 01-09-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim: The aim of present study was to assess the role of E-cadherin in oral carcinogenesis by comparing their expressions in normal oral mucosa, oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC). Materials and methods: To elucidate the pattern of E-cadherin expression in oral carcinogenesis, 21 archival cases of formalinfixed paraffin-embedded sections of OSCC, 21 OED, and 7 normal oral mucosa samples as control were used for the study. Results: We observed reduction/loss of E-cadherin in membranous expression pattern and staining intensity with progression from dysplasia to oral cancer. Conclusion: A decrease in staining intensity and loss of E-cadherin membranous expression were noted from dysplasia to carcinoma, suggesting its role as a tumor suppressor gene. Clinical significance: E-cadherin can be used as a biomarker to assess and evaluate the progression and prognosis of oral dysplastic lesions and OSCC.


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