The Journal of Contemporary Dental Practice

Register      Login

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue

Online First

Archive
Related articles

VOLUME 20 , ISSUE 11 ( November, 2019 ) > List of Articles

ORIGINAL RESEARCH

Local Formula with Mucoadhesive Property: A Randomized Clinical Trial of a Therapeutic Agent for the Treatment of Oral Aphthous Ulcers

Enrica Giammarinaro, Saverio Cosola, Giacomo Oldoini, Francesco Gulia, David Peñarrocha-Oltra, Simone Marconcini, Anna Maria Genovesi

Keywords : Keywords: Adjuvant therapy, Laser therapy, Mucoadhesive gel, Oral aphthous ulcers, Recurrent aphthosis

Citation Information : Giammarinaro E, Cosola S, Oldoini G, Gulia F, Peñarrocha-Oltra D, Marconcini S, Genovesi AM. Local Formula with Mucoadhesive Property: A Randomized Clinical Trial of a Therapeutic Agent for the Treatment of Oral Aphthous Ulcers. J Contemp Dent Pract 2019; 20 (11):1249-1253.

DOI: 10.5005/jp-journals-10024-2709

License: CC BY-NC 4.0

Published Online: 01-11-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: Recurrent or occasional aphthous lesions represent a painful oral condition with high prevalence. Since the etiology is still unclear and most likely related to a dysfunction in the local immune system, several treatment strategies have been proposed, including systemic agents, local agents, and laser therapy, to reduce the pain and discomfort for the patient without acting on the causes. Materials and methods: The purpose of the present randomized study was to assess the clinical efficacy of a new topical gel with mucoadhesive property to reduce the pain and the dimension of the aphthosis lesions. Fifty patients presenting at least one minor ulcer were randomized to a control group (placebo prescription), a first test group (topical agent with laser), and a second test group (topical agent only). The healing rate, the visual analog scale (VAS) score for pain, and the diameter reduction were monitored for 10 days. Results: Both test groups showed better results than control group, significant clinical efficacy, and a median total reduction time of 4 days with no significant adjunctive benefit from the use of laser. Conclusion: The clinical results are encouraging; nevertheless other studies are needed to valid this kind of treatment. Clinical significance: The present randomized clinical study suggested that the use of topical mucoadhesive agents could represent a valid therapy for minor aphthous lesions.


PDF Share
  1. Belenguer-Guallar I, Jiménez-Soriano Y, Claramunt-Lozano A. Treatment of recurrent aphthous stomatitis. A literature review. J Clin Exp Dent 2014;6(2):e168. DOI: 10.4317/jced.51401.
  2. Chavan M, Jain H, Diwan N, et al. Recurrent aphthous stomatitis: a review. J Oral Pathol Med 2012;41(8):577–583. DOI: 10.1111/j.1600-0714.2012.01134.x.
  3. Akintoye SO, Greenberg MS. Recurrent aphthous stomatitis. Dental Clin 2005;49(1):31–47.
  4. Natah SS, Konttinen YT, Enattah NS, et al. Recurrent aphthous ulcers today: a review of the growing knowledge. Int J oral Maxillofac Surg 2004;33(3):221–234. DOI: 10.1006/ijom.2002.0446.
  5. Barrons RW. Treatment strategies for recurrent oral aphthous ulcers. Am J Health Syst Pharm 2001;58(1):41–53.
  6. Suter VGA, Sjölund S, Bornstein MM. Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review. Lasers Med Sci 2017;32(4):953–963. DOI: 10.1007/s10103-017-2184-z.
  7. Zand N, Ataie-Fashtami L, Djavid GE, et al. Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation. Lasers Med Sci 2009;24(4):515–520. DOI: 10.1007/s10103-008-0555-1.
  8. Yilmaz HG, Albaba MR, Caygur A, et al. Treatment of recurrent aphthous stomatitis with Er, Cr:YSGG laser irradiation: a randomized controlled split mouth clinical study. J Photochem Photobiol B 2017;170:1–5. DOI: 10.1016/j.jphotobiol.2017.03.011.
  9. Zand N, Fateh M, Ataie-Fashtami L, et al. Promoting wound healing in minor recurrent aphthous stomatitis by non-thermal, non-ablative CO(2) laser therapy: a pilot study. Photomed Laser Surg 2012;30(12):719–723. DOI: 10.1089/pho.2012.3301.
  10. Cosola S, Giammarinaro E, Genovesi AM, et al. A short-term study of the effects of ozone irrigation in an orthodontic population with fixed appliances. Eur J Paediatr Dent 2019;20(1):15–18. DOI: 10.23804/ejpd.2019.20.01.03.
  11. Ofluoglu D, Ergun S, Warnakulasuriya S, et al. An evaluation of the efficacy of a topical gel with triester glycerol oxide (TGO) in the treatment of minor recurrent aphthous stomatitis in a Turkish cohort: a randomized, double-blind, placebo-controlled clinical trial. Med Oral Patol Oral Cir Bucal 2017;22(2):e159–e166. DOI: 10.4317/medoral.21469.
  12. Aslani A, Zolfaghari B, Davoodvandi F. Design, formulation and evaluation of an oral gel from punica granatum flower extract for the treatment of recurrent aphthous stomatitis. Adv Pharm Bull 2016;6(3):391–398. DOI: 10.15171/apb.2016.051.
  13. Samet N, Laurent C, Susarla SM, et al. The effect of bee propolis on recurrent aphthous stomatitis: a pilot study. Clin Oral Investig 2007;11(2):143–147. DOI: 10.1007/s00784-006-0090-z.
  14. Daněk Z, Gajdziok J, Doležel P, et al. Buccal films as a dressing for the treatment of aphthous lesions. J Oral Pathol Med 2017;46(4):301–306. DOI: 10.1111/jop.12563.
  15. Arafa MG, Ghalwash D, El-Kersh DM, et al. Propolis-based niosomes as oromucoadhesive films: a randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers. Sci Rep 2018;8(1):18056. DOI: 10.1038/s41598-018-37157-7.
  16. Giammarinaro E, Marconcini S, Genovesi A, et al. Propolis as an adjuvant to non-surgical periodontal treatment: a clinical study with salivary anti-oxidant capacity assessment. Minerva Stomatol 2018;67(5):183–188. DOI: 10.23736/S0026-4970.18.04143-2.
  17. Peterson DE, Srivastava R, Lalla RV. Oral mucosal injury in oncology patients: perspectives on maturation of a field. Oral Dis 2015;21(2):133–141. DOI: 10.1111/odi.12167.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.