Citation Information :
Ahmed N, Gopalakrishna V, Shetty A, Nagraj V, Imran M. Efficacy of PRF vs PRF + Biodegradable Collagen Plug in Post-extraction Preservation of Socket. J Contemp Dent Pract 2019; 20 (11):1323-1328.
Aim: To compare the clinical sequelae of the efficacy of PRF vs PRF + collagen plug in soft tissue healing and preservation of the socket width, height, and bone density in patients reporting for extractions of maxillary or mandibular anterior or posterior teeth and patients who desired replacement of teeth with dental implants in future.
Materials and methods: The study included 54 patients who were divided randomly into 3 groups consisting of 18 patients in each group: in group I, no preservation of extraction socket; in group II, PRF was used; and in group III, PRF + collagen plug was used for preservation of extraction socket. Assessment of the soft tissue healing, bone density, bone height, and width was done on 1st, 8th, 12th, and 16th weeks, postoperatively.
Result: Both PRF and PRF + Collaplug are comparable to each other in preserving the bone height, bone density, and also similar soft tissue healing; however PRF + Collaplug is better than PRF alone in preserving the bone width 4th month postoperatively, indicating that the resorbable Collaplug® does play an additional role in preserving the socket width.
Conclusion: PRF + Collaplug® has better clinical outcome in socket preservation in comparison to PRF alone. However, as results were not statistically significant, subjecting a larger sample size with PRF + Collaplug® for socket preservation may result in statistical critical values to substantiate our observations.
Clinical significance: PRF and Collaplug® can help in ridge preservation after extraction and also avoid additional bone grafting procedures in future implant placement for the patients.
Darby I, Chen S, et al. Ridge preservation: what is it and when should it be considered. Aust Dent J 2008;53:11–21. DOI: 10.1111/j.1834-7819.2007.00008.x.
Werbitt MJ, Goldberg PV. The immediate implant: bone preservation and bone regeneration. Int J Periodontics Restorative Dent 1992;12:206–217.
Chen ST, Wilson TG, et al. Immediate or early placement of implants following tooth extraction: review of biologic basis, clinical procedures and outcomes. Int J Oral Maxillofac Implants 2004;19(Suppl):12–25.
Lekovic V, Camargo PM, et al. Preservation of alveolar bone in extraction sockets using bioabsorable membranes. J Periodontol 1998 Sep;69(9):1044–1049. DOI: 10.1902/jop.19188.8.131.524.
Lekovic V, Kenney EB, et al. A bone regenerative approach to alveolar ridge maintenance following tooth extraction. Report of 10 cases. J Periodontol 1997 Jun;68(6):563–570. DOI: 10.1902/jop.19184.108.40.2063.
Schropp L, Wenzel A, et al. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent 2003;23:313–323.
Choukroun J, Adda F, et al. PRF: an opportunity in perio-implantology. Implantodontie 2000;42:55–62.
Tsai CH, Shen SY, et al. Platelet-rich fibrin modulates cell proliferation of human periodontally related cells in vitro. J Dent Sci 2009;4:130–135.
Landry R, Turnbull R, et al. Effectiveness of benzydamine HCl in the treatment of periodontal post-surgical patients. Res Clin Forums 1988;10:105–118.
Del Fabbro M, Bucchi C, et al. Healing of Post-Extraction Sockets Preserved with Autologous Platelet Concentrates. A Systematic Review and Meta-analysis. J Oral Maxillofac Surg 2017 Aug;75(8): 1601–1615. DOI: 10.1016/j.joms.2017.02.009.
Flugge T, Nelson K, et al. 2 Dimensional changes of the soft tissue profile of augmented and non-augmented human extraction sockets: a randomized pilot study. J Clin Periodontol 2015;42:390–397. DOI: 10.1111/jcpe.12386.
Dohan DM, de Peppo GM, et al. Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors 2009;27:63–69. DOI: 10.1080/08977190802636713.
Peck MT, Marnewick J, et al. Alveolar ridge preservation using leukocyte and platelet-rich fibrin: A report of a case. Case Rep Dent 2011;2011:345048. DOI: 10.1155/2011/345048.
Stevens MM. Biomaterials for bone tissue engineering. Mater Today 2008;11:18–25.
Serino G, Biancu S, et al. Ridge preservation following tooth extraction using a polylactide and polyglycolide sponge as space filler: a clinical and histological study in humans. Clin Oral Implants Res 2003;14:651–658.
Becker W, Becker BE, et al. A comparison of demineralized freeze-dried bone and autologous bone to induce bone formation in human extraction sockets. J Periodontol 1994;65:1128–1133. DOI: 10.1902/jop.19220.127.116.113.
Guarnieri R, Pecora G, et al. Medical grade calcium sulfate hemihydrate in healing of human extraction sockets: clinical and histological observations at 3 months. J Periodontol 2004;75:902–908. DOI: 10.1902/jop.2004.75.6.902.
Carmagnola D, Adriaens P, et al. Healing of human extraction sockets filled with Bio-Oss. Clin Oral Implants Res 2003;14(2):137–143.
Iasella JM, Greenwell H, et al. Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: A clinical and histologic study in humans. J Periodontol 2003;74:990–999. DOI: 10.1902/jop.2003.74.7.990.
Sasikarn S, Swasdison S, et al. Esthetic alveolar ridge preservation with calcium phosphate and collagen membrane: Preliminary report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:e24–e36. DOI: 10.1016/j.tripleo.2010.06.006.