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VOLUME 20 , ISSUE 4 ( April, 2019 ) > List of Articles

ORIGINAL RESEARCH

Correlation of Blood Glucose Levels, Salivary Glucose Levels and Oral Colony Forming Units of Candida albicans in Type 2 Diabetes Mellitus Patients

Aparna Trivedi, Sajda K Gajdhar, Harshad Bhagwat, Gaurav K Khutwad, Prashant E Mall

Keywords : Diabetics, Glucose oxidase kit, Oral candidal carriage, Salivary glucose, Sabouraud\'s dextrose agar

Citation Information : Trivedi A, Gajdhar SK, Bhagwat H, Khutwad GK, Mall PE. Correlation of Blood Glucose Levels, Salivary Glucose Levels and Oral Colony Forming Units of Candida albicans in Type 2 Diabetes Mellitus Patients. J Contemp Dent Pract 2019; 20 (4):494-498.

DOI: 10.5005/jp-journals-10024-2545

License: CC BY-NC 4.0

Published Online: 01-04-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim: The study aims to correlate salivary glucose, blood glucose levels and oral colony forming units of Candida albicans and to evaluate whether saliva can be used as noninvasive means to measure glycemic status in type II diabetics without the need for the invasive procedure. Materials and methods: The study included 100 type II diabetic patients (group I) of both genders with age 40 years and above and 100 healthy patients (group II), age and sex matched with the study group. Group I includes uncontrolled and controlled diabetics as groups IA and IB, respectively. Salivary glucose measurement was done using the enzymatic colorimetric method and blood glucose levels measured by doing venepuncture and centrifuged. The oral candidal carriage was calculated by incubation in Sabouraud\'s dextrose agar supplemented with chloramphenicol and incubated aerobically for 48 hours. To compare the mean values Z test was applied. To determine the relationship between two variables Pearson\'s correlation coefficient was used. Results: The salivary glucose levels showed a significant correlation with blood glucose levels. The salivary candida carriage was higher in uncontrolled as compared to controlled diabetics and healthy individuals. Conclusion: Positive correlation was obtained between salivary glucose and blood glucose in diabetics and candidal carriage has a positive correlation with blood glucose levels. This salivary glucose and blood glucose levels correlation confirms its use to find glycemic status in diabetic patients. Clinical significance: The positive correlation of salivary glucose with blood glucose shows that it can be utilized as a noninvasive tool for monitoring glycemic status in diabetic patients.


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  1. Sashikumar R, Kannan R. Salivary glucose levels and oral candidal carriage in type II diabetics. Oral Surgery, Oral Medicine Oral Pathology, Oral Radiology and Endodontology 2010;109(5):706-711.
  2. Manfredi M, Cullough MJ, Vescovi P, et al. Updates on diabetes mellitus and related oral diseases. Oral Diseases 2004;10: 187-200.
  3. Soares MSM, Batista- Filho MMV, Pimentel MJ, et al. Determination of salivary glucose in healthy adults. Med Oral Patol Oral Cir Buccal 2009;14(10):e510-e513.
  4. Ship JA. Diabetes and oral health, an overview. Journal of American Dental Association 2003;134:4s-10s.
  5. Vaziri PB, Vahedi M, Mortazavi H, et al. Evaluation of salivary glucose, IgA and flow rate in diabetic patients: a case control study. Journal of Dentistry 2010;7(1):13-18.
  6. Elkafri IH, Mashlah A, Shaqifa A. Relationship between blood glucose levels and salivary pH and buffering capacity in type II diabetes patients. East Mediterr Health J 2014;20:139-45.
  7. Panchbhai AS. Correlation of salivary glucose level with blood glucose level in diabetes mellitus. J Oral Maxillofac Res. 2012;3:e3.
  8. Carda C, Mosquera-Lloreda N, Salom L, et al. Structural and functional salivary disorders in type 2 diabetic patients. Med Oral Patol Oral Cir Bucal. 2006;11:E309-E314. [PubMed]
  9. AL-Attas A, Amro SO. Candidal colonization, strain diversity and antifungal susceptibility among adult diabetic patients. Ann Saudi Med 2010 Mar-Apr;30(2): 101-108.
  10. Abu-Elteen KH, Hamad MA, Salah SA. Prevalence of oral candida infections in diabetic patients. Bahrain Medical Bulletin 2006; 28 (1): 1-8.
  11. Borg Andersson A, Birkhed D, Berntorp K, et al. Glucose concentration in parotid saliva after glucose/food intake in individuals with glucose intolerance and diabetes mellitus. Eur J Oral Sci 1998;106:931-937
  12. Panchbhai AS, Degewekar SS, Bhowte R. Estimation of salivary glucose, salivary amylase, salivary total protein, salivary flow rate in diabetics in India. Journal of Oral Science 2010;52:359-368.
  13. Amer S, Yousef M, Siddique PQ, et al. Salivary glucose concentration in patients with diabetes mellitus - a minimally invasive technique for monitoring blood glucose levels. Pak J of Pharm Sci Jan 2001;14(1):33-37.
  14. Tapper-Jones LM, Aldred MJ, Walker DM, Hayes TM. Candidal infections and populations of candida albicans in mouths of diabetics. J Clin Pathol 1981; 34:706-711.
  15. Kumar BV, Padshetty NS et al. Prevalence of candida in the oral cavity of diabetic subjects. Journal of Biomedicine & Biotechnology 2009; 10:11-55
  16. Darwazeh AM, MacFarlane TW, McCuish A, et al. Mixed salivary glucose levels and candidal carriage in patients with diabetes mellitus. J Oral Pathol Med 1991;20:280-283.
  17. Kartheeki B, Abhishek S N, Ravikiran A, et al. Serum and salivary glucose levels in diabetes mellitus: A Review. Nigerian J of general practice 2017;15(2):17-21.
  18. Abikshyeet P, Ramesh V, Oza N. Glucose estimation in the salivary secretion of diabetes mellitus patients. Diabetes Metab Syndr Obes 2012;5:149-154.
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