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VOLUME 20 , ISSUE 7 ( July, 2019 ) > List of Articles

REVIEW ARTICLE

Histomorphological Evidence of Cellular Cannibalism in Ameloblastoma

Amol R Gadbail, Shailesh Gondivkar

Keywords : Ameloblastoma, CD68, Cellular cannibalism, Lysozyme

Citation Information : Gadbail AR, Gondivkar S. Histomorphological Evidence of Cellular Cannibalism in Ameloblastoma. J Contemp Dent Pract 2019; 20 (7):863-866.

DOI: 10.5005/jp-journals-10024-2612

License: CC BY-NC 4.0

Published Online: 01-07-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim: To study the cellular cannibalism (CC) in the tumor cells of ameloblastoma. Materials and methods: Hematoxylin and eosin (HE)-stained sections of ameloblastoma cases (50) were retrieved from the archived specimens and screened for cellular cannibalism (CC) by stellate reticulum-like cells. Further characterization of CC was performed using CD68 and lysozyme antibodies. Results: CC was observed in 15 (30%) cases [follicular 10 (66.66%), unicystic 3 (20%), and acanthomatous 2 (13.33%)]. In acanthomatous ameloblastoma, the CC was observed in the central metaplastic squamous cells, while in 3 cases of unicystic ameloblastoma, CC was seen in stellate reticulum-like cells of intraluminal (2) and mural proliferations (1). All the 15 cases of ameloblastoma showed a negative expression of CD68 as well as lysozyme. Conclusion: CC is a new addition to the pathogenesis of ameloblastoma.


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  1. Sharma N, Dey P. Cell cannibalism and cancer. Diagn Cytopathol 2011;39:229–233. DOI: 10.1002/dc.21402.
  2. Sarode GS, Sarode SC, et al. Complex cannibalism: an unusual finding in oral squamous cell carcinoma. Oral Oncol 2012;48:e4–e6. DOI: 10.1016/j.oraloncology.2011.08.013.
  3. Sarode SC, Sarode GS, et al. Endocytosis of keratinocytes in oral squamous cell carcinoma: expression of phagocytic markers. Transl Res Oral Oncol 2016. DOI: 10.1177/2057178X15618551.
  4. Alfarouk KO. Tumor acidity as evolutionary spite. Cancers 2011;3: 408–414. DOI: 10.3390/cancers3010408.
  5. Steinhaus J. Ueber carcinoma-einschlusse. Virchows Arch 1891; 126:533–535. DOI: 10.1007/BF01937613.
  6. Reichart PA, Philipsen HP, et al. Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol 1995;31B(2):86–99. DOI: 10.1016/0964-1955(94)00037-5.
  7. Ramprasad MP, Terpstra V, et al. Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein. Proc Natl Acad Sci U S A 1996;93:14833–14838. DOI: 10.1073/pnas.93.25.14833.
  8. Strynadka NC, James MN. Lysozyme revisited: crystallographic evidence for distortion of an N-acetylmuramic acid residue bound in site D. J Mol Biol 1991;220:401–424. DOI: 10.1016/0022-2836(91) 90021-W.
  9. Brouwer M, de Ley L, et al. Serum dependent “cannibalism” and auto-destruction in cultures of human small cell carcinoma of lung. Cancer Res 1984;44:2947–2951.
  10. Sarode SC, Sarode GS. Cellular cannibalism in central and peripheral giant cell granuloma of the oral cavity can predict biological behavior of the lesion. J Oral Pathol Med 2014;43(6):459–463. DOI: 10.1111/jop.12119.
  11. Sarode GS, Sarode SC, et al. Cellular cannibalism in giant cells of central giant cell granuloma of jaw bones and giant cell tumors of long bones. J Investig Clin Dent 2017;8(2). DOI: 10.1111/jicd.12214.
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