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VOLUME 20 , ISSUE 7 ( July, 2019 ) > List of Articles


Histomorphological Evidence of Cellular Cannibalism in Ameloblastoma

Amol R Gadbail, Shailesh Gondivkar

Keywords : Ameloblastoma, CD68, Cellular cannibalism, Lysozyme

Citation Information : Gadbail AR, Gondivkar S. Histomorphological Evidence of Cellular Cannibalism in Ameloblastoma. J Contemp Dent Pract 2019; 20 (7):863-866.

DOI: 10.5005/jp-journals-10024-2612

License: CC BY-NC 4.0

Published Online: 01-08-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Aim: To study the cellular cannibalism (CC) in the tumor cells of ameloblastoma. Materials and methods: Hematoxylin and eosin (HE)-stained sections of ameloblastoma cases (50) were retrieved from the archived specimens and screened for cellular cannibalism (CC) by stellate reticulum-like cells. Further characterization of CC was performed using CD68 and lysozyme antibodies. Results: CC was observed in 15 (30%) cases [follicular 10 (66.66%), unicystic 3 (20%), and acanthomatous 2 (13.33%)]. In acanthomatous ameloblastoma, the CC was observed in the central metaplastic squamous cells, while in 3 cases of unicystic ameloblastoma, CC was seen in stellate reticulum-like cells of intraluminal (2) and mural proliferations (1). All the 15 cases of ameloblastoma showed a negative expression of CD68 as well as lysozyme. Conclusion: CC is a new addition to the pathogenesis of ameloblastoma.

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