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VOLUME 21 , ISSUE 4 ( April, 2020 ) > List of Articles


Effect of Nonsurgical Periodontal Therapy on Serum Level of Interleukin-6 and Tumor Necrosis Factor-α in Chronic Periodontitis Patients with and without Hypothyroidism

Indhuja R Saraswathi, Arun Sadasivan, Elizabeth Koshi, Steffi Vijayakumar, Chitra G Vallabhan, Sheethel M Vrinda

Keywords : Hypothyroidism, Interleukin-6, Periodontitis, Thyroid function test, Tumor necrosis factor-α

Citation Information : Saraswathi IR, Sadasivan A, Koshi E, Vijayakumar S, Vallabhan CG, Vrinda SM. Effect of Nonsurgical Periodontal Therapy on Serum Level of Interleukin-6 and Tumor Necrosis Factor-α in Chronic Periodontitis Patients with and without Hypothyroidism. J Contemp Dent Pract 2020; 21 (4):410-415.

DOI: 10.5005/jp-journals-10024-2812

License: CC BY-NC 4.0

Published Online: 25-06-2012

Copyright Statement:  Copyright © 2020; The Author(s).


Aim: The aim of this article was to determine the effect of nonsurgical periodontal therapy on clinical parameters and also to evaluate serum level of interleukin (IL)-6 and tumor necrosis factor (TNF)-α in chronic periodontitis patients with and without hypothyroidism. Materials and methods: Subjects were 40 female patients (20 systemically healthy subjects with chronic periodontitis and 20 subjects with hypothyroidism and chronic periodontitis). Clinical parameters like plaque score, gingival score, gingival recession, probing pocket depth, and clinical attachment level were recorded at baseline and 4 weeks after nonsurgical periodontal therapy. Nonsurgical periodontal therapy included oral hygiene instructions and full-mouth scaling and root planing. A total of 5 mL of venous blood sample was collected from each subject at baseline and 4 weeks after nonsurgical periodontal therapy. Results: The clinical parameters and biochemical parameters like IL-6 and TNF-α in both groups showed pronounced reduction at the end of 4 weeks following nonsurgical periodontal therapy. However, simultaneous comparison of clinical and biochemical parameters between the two groups was not statistically significant. Conclusion: This study provides evidence that nonsurgical periodontal therapy contribute to reduction in serum level of IL-6 and TNF-α in systemically healthy subjects with chronic periodontitis and subjects with hypothyroidism and chronic periodontitis. Clinical significance: The prevalence of periodontitis as well as hypothyroidism is increasing nowadays. Interleukin-6 and TNF-α are found to play a significant role in pathobiology of both periodontitis and hypothyroidism. With the treatment of periodontitis, it is found that there is improvement in periodontal and thyroid status of the patients. So, it is an alert to health professionals about the relation of hypothyroidism and periodontitis so that they consider a multidisciplinary approach.

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