The Journal of Contemporary Dental Practice

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 21 , ISSUE 9 ( September, 2020 ) > List of Articles


A Comparative Study of Platelet-rich Fibrin (PRF) and Titanium-prepared Platelet-rich Fibrin (T-PRF) in Management of Endo-perio Lesions

Mohammed A Razi, Ankit Mahajan, Seema Qamar, Salil Mehra, Tulika Rani Roy, Puja Kumari

Keywords : Endo-perio lesions, Platelet-rich fibrin, Titanium-prepared platelet-rich fibrin

Citation Information : Razi MA, Mahajan A, Qamar S, Mehra S, Roy TR, Kumari P. A Comparative Study of Platelet-rich Fibrin (PRF) and Titanium-prepared Platelet-rich Fibrin (T-PRF) in Management of Endo-perio Lesions. J Contemp Dent Pract 2020; 21 (9):997-1001.

DOI: 10.5005/jp-journals-10024-2865

License: CC BY-NC 4.0

Published Online: 21-10-2020

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Aim: The aim of the study was to compare the platelet-rich fibrin (PRF) and titanium-prepared platelet-rich fibrin (T-PRF) in the management of endo-perio lesions. Materials and methods: This study was conducted with 140 patients who are affected by endo-perio lesions, and the patients were divided into two groups. In group I, patients were treated with PRF, and in group II, patients were treated with T-PRF. Endodontic treatment was done in all cases, following a standardized aseptic method. Probing pocket and relative attachment level were recorded after 3 months and 6 months in both groups. Results: After 3 months, the mean change of probing pocket depth (PPD) was 68% in group I and 33.41% in group II. The intergroup distinction was not significant (p > 0.05), whereas the intragroup evaluation was significant (p < 0.05). The mean change after 6 months was 42.59% in group I and 43.90% in group II. The difference was not significant (p > 0.05). After 3 months, the mean% change of relative attachment level (RAL) was 31.20% in group I and 31.60% in group II. The intergroup distinction was not significant (p > 0.05), whereas the intragroup evaluation established a considerable discrepancy (p < 0.05). The mean change after 6 months was 40.82% in group I and 42.12% in group II. Conclusion: Both PRF and T-PRF were effective in inducing a reduction in pocket depth and useful in gaining attachment level. Clinical significance: With the use of PRF and T-PRF, the complex case of endo-perio lesions can be efficiently managed.

PDF Share
  1. Sharma A, Pradeep AR. Treatment of 3-wall intrabony defects in patients with chronic periodontitis with autologous platelet-rich fibrin: a randomized controlled clinical trial. J Periodontol 2011;82(12):1705–1712. DOI: 10.1902/jop.2011.110075.
  2. Thorat M, Pradeep AR, Pallavi B. Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial. J Clin Periodontol 2011;38(10):925–932. DOI: 10.1111/j.1600-051X.2011.01760.x.
  3. Aroca S, Keglevich T, Barbieri B, et al. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 2009;80(2):244–252. DOI: 10.1902/jop.2009.080253.
  4. Vishwanath V, Rao HM, Keshava Prasad BS, et al. Successful endodontic management of endo-perio lesions with different treatment modalities: case series. SRM J Res Dent Sci 2019;10(2):105–109. DOI: 10.4103/srmjrds.srmjrds_16_19.
  5. Tunalı M, Özdemir H, Küçükodacı Z, et al. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg 2012;51(5):438–443. DOI: 10.1016/j.bjoms.2012.08.003.
  6. Chatterjee A, Pradeep AR, Garg V, et al. Treatment of periodontal intrabony defects using autologous platelet-rich fibrin and titanium platelet rich fibrin: a randomized, clinical, comparative study. J Investig Clint Dent 2017;8:e12231. DOI: 10.1111/jicd.12231.
  7. Eren G, Tervahartiala T, Sorsa T, et al. Cytokine (interleukin-1beta) and MMP levels in gingival crevicular fluid after use of platelet-rich fibrin or connective tissue graft in the treatment of localized gingival recessions. J Periodontal Res 2016;51:481–488. DOI: 10.1111/jre.12325.
  8. Dohan Ehrenfest DM, Del Corso M, Diss A, et al. Three-dimensional architecture and cell composition of a Choukroun's platelet-rich fibrin clot and membrane. J Periodontol 2010;81:546–555. DOI: 10.1902/jop.2009.090531.
  9. Dambhare A, Bhongade ML, Dhadse PV, et al. A randomized controlled clinical study of autologous platelet rich fibrin (PRF) in combination with HA and beta-TCP or HA and beta-TCP alone for treatment of furcation defects. J Hard Tissue Biol 2019;28(2):185–190. DOI: 10.2485/jhtb.28.185.
  10. Goyal L, Gupta N, Gupta ND. Autologous platelet-rich derivatives along with alloplastic bone substitute in the management of complex perio-endo cases. J Indian Soc Periodontol 2020;24(2):182–185. DOI: 10.4103/jisp.jisp_81_19.
  11. Patel GK, Deepika PC, Sisodia N, et al. Platelet rich fibrin in management of complex endoperio cases. Kathmandu Univ Med J (KUMJ) 2017;15(57):102–105.
  12. Singh PK, Kumari A. Prevalence and distribution of different types of bone defects in chronic periodontitis in Bagalkot subjects: a clinical study. Int J Sci Stud 2017;5(3):284–289.
  13. Indurkar MS, Verma R. Evaluation of the prevalence and distribution of bone defects associated with chronic periodontitis using cone-beam computed tomography: a radiographic study. J Interdiscip Dent 2016;6(3):104–109. DOI: 10.4103/2229-5194.201647.
  14. Sachdeva S, Phadnaik MB, Mania A, et al. Prevalence and distribution of bone defects associated with moderate and severe periodontitis patients. Clinical Epidemiology and Global Health 2020; 1–6. [In press].
  15. Najim U, Norderyd O. Prevalence of intrabony defects in a swedish adult population. A radiographic epidemiological study. Acta Odontologica Scandinavica 2017;17(2):123–129. DOI: 10.1080/00016357.2016.1265665.
  16. Wu SK, Yeh HC, Chan CP. The prevalence and distribution of bone defects in patients with moderate to advanced periodontitis. Chang Gung Med J 2001;24(7):423–430.
  17. Mitra DK, Potdar PN, Prithyani SS, et al. Comparative study using autologous platelet-rich fibrin and titanium prepared platelet-rich fibrin in the treatment of infrabony defects: an in vitro and in vivo study. J Indian Soc Periodontol 2019;23(6):554–561. DOI: 10.4103/jisp.jisp_562_18.
  18. Shashikumar P, Nisha S. Autologous platelet concentrate as a potential regenerative biomaterial in the treatment of endo-perio lesion. Indian J Oral Health Res 2016;2:106–109. DOI: 10.4103/2393-8692.196148.
  19. Yu-Chao C, Kuo-Chin W, Jiing-Huei Z. Clinical application of platelet-rich fibrin as the sole grafting material in periodontal intrabony defects. J Dent Sci 2011;6:181–188. DOI: 10.1016/j.jds.2011. 05.010.
  20. Maniyar N, Sarode GS, Sarode SC, et al. Platelet-rich fibrin: a “wonder material” in advanced surgical dentistry. Med J DY Patil Vidyapeeth 2018;11:287–290. DOI: 10.4103/MJDRDYPU.MJDRDYPU_204_17.
  21. Del Fabbro M, Ceresoli V, Lolato A, et al. Effect of platelet concentrate on quality of life after periradicular surgery: a randomized clinical study. J Endod 2012;38(6):733–739. DOI: 10.1016/j.joen.2012. 02.022.
  22. Monga P, Grover R, Mahajan P, et al. A comparative clinical study to evaluate the healing of large periapical lesions using platelet-rich fibrin and hydroxyapatite. Endodontology 2016;28:27–31. DOI: 10.4103/0970-7212.184336.
  23. Jayalakshmi KB, Agarwal S, Singh MP, et al. Platelet-rich fibrin with β-tricalcium phosphate-a novel approach for bone augmentation in chronic periapical lesion: a case report. Case Rep Dent 2012;2012:902858. DOI: 10.1155/2012/902858.
  24. Thanikasalam M, Ahamed S, Narayana SS, et al. Evaluation of healing after periapical surgery using platelet-rich fibrin and nanocrystalline hydroxyapatite with collagen in combination with platelet-rich fibrin. Endodontology 2018;30:25–31.
  25. Deenadayalan E, Kumar A, Tewari RK, et al. Management of large periapical lesion with the combination of second generation platelet extract and hydroxyapatite bone graft: a report of three cases. J Clin Diagn Res 2015;9(1):ZD24–ZD27. DOI: 10.7860/JCDR/2015/10885.5482.
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.