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VOLUME 22 , ISSUE 3 ( March, 2021 ) > List of Articles

ORIGINAL RESEARCH

Clinical Efficacy of Aloe Vera Toothpaste on Periodontal Parameters of Patients with Gingivitis—A Randomized, Controlled, Single-masked Clinical Trial

Ferena Sayar, Amirhossein Farahmand, Maryam Rezazadeh

Keywords : Aloe vera, Gingivitis, Oral hygiene, Toothpaste

Citation Information : Sayar F, Farahmand A, Rezazadeh M. Clinical Efficacy of Aloe Vera Toothpaste on Periodontal Parameters of Patients with Gingivitis—A Randomized, Controlled, Single-masked Clinical Trial. J Contemp Dent Pract 2021; 22 (3):242-247.

DOI: 10.5005/jp-journals-10024-3059

License: CC BY-NC 4.0

Published Online: 01-03-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim and objective: This study aims to assess the effects of aloe vera toothpaste on dental plaques and gingivitis. Materials and methods: This single-center, single-blind, randomized, two-period crossover study was performed on 20 dental students with a mean age of 24.5 ± 4 years with gingivitis. Subjects were randomly assigned to two groups (n = 10). After 14 days of trial period, plaque index (PI) and gingival index (GI) were assessed for each group. The first group used aloe vera toothpaste for 30 days and then their PI and GI were recorded. A 2-week washout period was allowed and then the subjects used fluoride toothpaste for the next 30 days and underwent PI and GI assessment again. This order was reversed in group 2. Results: Toothpaste-containing aloe vera showed no significant improvement in the GI and PI scores as compared with a fluoride-containing dentifrice. PI was 2.14 ± 1.3 at baseline and 1.84 ± 1.02 in 30 days (p <0.098). GI was 0.62 ± 0.74 at baseline and 0.25 ± 0.46 at 30 days (p <0.068). During the trial, no side effects were seen due to the use of aloe vera or fluoride toothpaste. Conclusion: The effect of aloe vera toothpaste on PI and GI was similar to that of fluoride toothpaste and it seems that this toothpaste can be used as an alternative to a chemical toothpaste. Clinical significance: The use of an aloe vera toothpaste in improving the progression of gingivitis can be evaluated.


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  1. Silva N, Abusleme L, Bravo D,Dutzan N JGarcia-Sesnich J, Rolando Vernal Marcela Hernández, Jorge Gamonal. Host response mechanisms in periodontal diseases. J Appl Oral Sci May-Jun 2015;23(3):329-55.
  2. De la Rosa M, Zacarias Guerra J, Johnston DA, Radike AW. Plaque growth and removal with daily toothbrushing. J Periodontol 1979; 50:661-664.
  3. Anneroth G, Poppleman A. Histological evaluation of gingival damage by toothbrushing. An experimental study in the dog. Acta Odontologica Scandinavica 1975; 33: 119–27.
  4. Sangnes G. Traumatization of teeth and gingivae related to habitual tooth cleaning. Review article. Journal Clinical Periodontology 1976; 3:94–103.
  5. Sangnes G, Gjermo P. Prevalence of oral soft and hard tissue lesions related to mechanical tooth cleaning procedures. Community Dentistry and Oral Epidemiology 1976; 4:77–83.
  6. Sandholm L, Niemi ML, Ainamo J. Identification of soft tissue brushing lesion. A clinical and scanning electron microscopic study. Journal of Clinical Periodontology1982; 9:397–401.
  7. Niemi ML, Sandholm L, Ainamo J. Frequency of gingival lesions after standardized brushing as related to stiffness of toothbrush and abrasiveness of toothpaste. Journal of Clinical Periodontology 1984; 11:254–61.
  8. Forward GC, James AH, Barnett P, Jackson RJ. Gum health product formulations: What is in them and why? Periodontol 2000; 1997:15: 32-9.
  9. Rubido S, García-Caballero Lucía, Abeleira MT, Limeres J, García M, Diz P. Effect of che wing an apple on dental plaque removal and on salivary bacterial viability. PLoS One. 2018 Jul 18;13(7):e0199812.
  10. Mandel ID. Chemotherapeutic agents for controlling plaque and gingivitis. J Clin Periodontol 1988; 15:488-98.
  11. Jepsen S. The role of manual toothbrushes in effective plaque control: advantages and limitations. In: Lang, N.P., Attström, R. & Löe, H., eds. Proceedings of the European Workshop on Mechanical Plaque Control. London: Quintessence, 1998; 121-137.
  12. Samuels N, Grbic JT. Effect of an herbal mouth rinse in preventing periodontal inflammation in an experimental gingivitis model: a pilot study. Compend Contin Educ Dent. 2012:33(3):204-6,208-211.
  13. Ashwini Somu C, Ravindra S. Efficacy of an herbal exact gel in the treatment of gingivitis. J Ayurveda Inter Med 2012;3(2):85–90.
  14. De Oliveira SM, Torres TC, Pereira SL, et al. Effect of a dentifrice containing Aloe vera on plaque and gingivitis control. A double-blind clinical study in humans. J Appl Oral Sci 2008;16(4):293–296.
  15. Eshun K, He Q. Aloevera;a valuable ingredient for the food, pharmaceutical and cosmetic industries. Crit Rev Food Sci Nutr 2004;44(2):91–96. DOI: 10.1080/10408690490424694.
  16. Fani MM, Kohanteb J. Inhibitory activity of aloe vera on some clinically isolated cariogenic and periodontopathic bacteria. J Oral Sci 2012;54(1):15–21. DOI: 10.2334/josnusd.54.15.
  17. Lee SS, Zhang W, Li Y. The antimicrobial potential of 14 natural herbaldentifrices. J Am Dent Assoc 2004;135(8):1133–1141.
  18. Grindlay D, Reynolds T. The Aloe vera phenomenon: a review of the properties and modern uses of leaf parenchyma gel. J Ethnopharmacol 1986;16(2-3):117–151.
  19. Sudworth R. The use of Aloe Vera in dentistry. Philadelphia: Positive Health Publications Ltd; 2002.
  20. Tello CG, Ford P, Iacopino AM. In vitro evaluation of complex carbohydrate denture adhesive formulations. Quintessence Int1998 Sep ;29(9):585-93.
  21. Goerge J, Hegde S, Rajesh KS, et al. The efficacy of a herbal-based toothpaste in the control of plaque and gingivitis. Indian J Dent Res 2009;20(4):480-482.
  22. Pradeep AR, Agarwal E, Niak SB. Clinical and microbiologic effect of commercially available dentifrice containing aloe vera:A randomized controlled clinical trial. J Periodontol 2012;83(6):797–804.
  23. Ponnutis CM, Maltas J. Clinical effect of an herbal dentifrice on the control of plaque and gingivitis. Pesqui Odontol Bras 2003;17(4):314– 318.
  24. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract1999 Oct;49(447):823-8.
  25. Choi SW, Son BW. The wound-healing effect of a glycoprotein fraction isolated from aloe vera. Br J Dermatol 2001;145(4):535–545.
  26. Reuter J, Jocher A. Investigation of the anti-inflammatory potential of aloe vera gel (97.5) in the ultraviolet erythema test. Skin Pharmacol Physiol 2008;21(2):106–110.
  27. MaiaFilho AL, Villaverde AB. Comparative study of the topical application of Aloe vera gel, therapeutic ultrasound and phonophoresis on the tissue repair in collagenase-induced rat tendinitis. Ultrasound Med Biol 2010;36(10):1682–1690.
  28. Park MY, Kwon HJ,Sung MK. Ditaryaloein, aloesin, or aloe-gel extract anti-inflammatory activity in arat colitis model. Life Sci 2011;88(11– 12):486–492
  29. George D, Bhat SS, Antony B. Comparative evaluation of the antimicrobial efficacy of aloe vera tooth gel and two popular commercial toothpastes: an in- vitro study. GenDent. May-Jun2009;57(3):238-41.
  30. Loe H, Silness J. Periodontal diseases in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533–551.
  31. Quigley GA, Hein JW. Comparative cleansing efficiency of manual and power brushing. J Am Dent Assoc 1962;65:26–29.
  32. Turesky S, Gilmore ND, Glickman I. Reduced plaque formation by the chloromethyl analogue of vitamin C. J Periodontol 1970;41(1):41-43.
  33. Disyam L. A comparison of three methods of toothbrushing: roll, modified Bass and scrub technique. J Dent Assoc Thai Jan-Feb 1987; 37(1):1-10.
  34. Villalobos OJ, Salazar CR, Sánchez GR. Efecto de un enjuague bucal compuesto de aloe vera en la placa bacteriana e inflamación gingival. Acta Odontol Venez. 2001; 39(2):16–24.
  35. Axelsson P, Lindhe J. The significance of maintenance care in the treatment of periodontal disease. J Clin Periodontol 1981;8(4):281– 294.
  36. Wilson TG Jr, Glover ME, Malik AK, et al. Tooth loss in maintenance patients in a private periodontal practice. J Periodontol 1987;58(4):231–235.
  37. Al-kholani Al. Comparison between the Efficacy of Herbal and Conventional Dentifrices on Established Gingivitis. Dent Res J (Isfahan). Spring 2011;8(2):57-63.
  38. Cobb CM. Non-surgical pocket therapy: mechanical. Ann Periodontol 1996; 1(1):443-490.
  39. McNabb H, Mombelli A, Lang NP. Supragingival cleaning 3 times a week. The microbiological effects in moderately deep pockets. J Clin Periodontol 1992;19(5):348–356.
  40. Hellstrom MK, Ramberg P, Krok L, et al. The effect of supragingival plaque control on the subgingival microflora in human periodontitis. J Clin Periodontol 1996;23(10):934–940.
  41. Karim B, Bhaskar DJ, Agali C, et al. Effect of Aloe vera mouthwash on periodontal health: triple blind randomized control trial. Oral Health Dent Manag 2014;13(1):14–19.
  42. Saito H, Ishiguro T, Imanishi K, et al. Pharmacological studies on a plant lectin aloctin A. II. Inhibitory effect of aloctin A on experimental models of inflammation in rats. Jpn J Pharmacol 1982;32(1):139–142.
  43. Hutter JA, Salman M, Stavinoha WB, et al. Antiinflammatory C-glucosyl chromone from Aloe barbadensis. J Nat Prod 1996;59(5):541–543.
  44. Klein AD, Penneys NS. Aloe Vera. J Am Acad Dermatol 1988;18(4 Pt 1):714–720.
  45. Yagi A, Kabash A, Okamura N, et al. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Planta Med 2002;68(11):957–960.
  46. Heggers JP, Robson MC. Burns: prostaglandins and thromboxane. Crit Care Clin 1985;1:59–77.
  47. Vazquez B, Avila G, David S, et al. Anti-inflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol 1996;55(1):69–75.
  48. Fialkow L, Wang Y, Downey GP. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med 2007;42(2):153–164.
  49. Ashouri Moghaddam A, Radafshar G, Jahandideh Y, Kakaei N. Clinical evaluation of effects of local application of aloe vera gel as an adjunct to scaling and root planning in patients with chronic periodontitis. J Dent (Shiraz) 2017;18(3):165–172.
  50. Hudwekar AD, Beldar A, Murkute S, et al. Aloe vera on wound healing after periodontal flap surgery in chronic periodontitis patient: A randomized control trial. J Oral Res Rev 2019;11(2):72–76.
  51. Elsadek MF, Ahmed BM, Eskandrani RM, et al. Clinical and microbiological outcomes of topical aloe vera gel vs. photochemotherapy as an adjunct to non-surgical periodontal treatment in periodontitis. Planta Med Int Open 2020;7(3):e100–e105.
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