Citation Information :
Shahid I, Seshadri M. Florid Cemento-osseous Dysplasia: A Report of Two Cases and Literature Review. J Contemp Dent Pract 2021; 22 (3):304-309.
Aim: This report aims to provide the clinical and radiographic features of two symptomatic Indian patients with florid cemento-osseous dysplasia (FCOD), along with a discussion of the differential diagnosis, potential challenges, and therapeutic implications.
Background: FCOD is a rare, multifocal, periapical, and bilateral condition involving the premolar and molar region of the posterior mandible and sometimes the maxilla.
Case description: The first patient is a 30-year-old female with a recent history of dental pain. The patient was otherwise healthy and the medical history was unremarkable. The second patient is a 50-year-old female with a history of orthodontic therapy. Radiographic evaluation using cone-beam computed tomography (CBCT) revealed bilateral involvement of the posterior mandible, sparing the entire maxilla in both patients
Clinical significance: For a pathognomonic condition like FCOD, a radiology survey alone is often sufficient to arrive at the final diagnosis, and therefore surgical interventions should ideally be avoided.
MacDonald-Jankowski DS. Florid cemento-osseous dysplasia: a systematic review. Dentomaxillofac Radiol 2003;32(3):141–149. DOI 10.1259/dmfr/32988764.
Waldron CA, Giansanti JS, Browand BC. Sclerotic cemental masses of the jaws (so called chronic sclerosingosteomyelitis, sclerosing osteitis, multiple enostosis, and gigantiform cementoma). Oral Surg Oral Med Oral Pathol 1975;39(4):590–604. DOI: 10.1016/0030-4220(75)90201-7.
Melrose RJ, Abrams AM, Mills BG. Florid osseous dysplasia. A clinical-pathologic study of thirty-four cases. Oral Surg Oral Med Oral Pathol 1976;41(1):62–82. DOI: 10.1016/0030-4220(76)90254-1.
Sarmento DJ, Monteiro BV, de Medeiros AM, et al. Severe florid cemento-osseous dysplasia: a case report treated conservatively and literature review. Oral Maxillofac Surg 2013;17(1):43–46. DOI: 10.1007/s10006-012-0314-0.
Delai D, Bernardi A, Felippe GS, et al. Florid cemento-osseous dysplasia: a case of misdiagnosis. J Endod 2015;41(11):1923–1926. DOI: 10.1016/j.joen.2015.08.016.
Huh J-K, Shin SJ. Misdiagnosis of florid cemento-osseous dysplasia leading to unnecessary root canal treatment: a case report. Restor Dent Endod 2013;38(3):160–166. DOI: 10.5395/rde.2013.38.3.160.
Krishnan U, Al Maslamani M, Moule AJ. Cone beam CT as an aid to diagnosing mixed radiopaque radiolucent lesions in the mandibular incisor region. BMJ Case Rep 2015;2015:bcr2014207617. DOI: 10.1136/bcr-2014-207617.
Wood NK, Goaz PW. Differential diagnosis of oral and maxillofacial lesions. 5th ed. St. Louis, MO: Mosby; 1997.
Martini MZ, Rocha AC, Lemos CA Jr, et al. Fibro-osseous lesions associated with simple bone cysts: three case reports and review of the literature. Minerva Stomatol 2010;59(11–12):671–676.
Peacock ME, Krishna R, Gustin JW, et al. Retrospective study on idiopathic bone cavity and its association with cemento-osseous dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol 2015;119(4):e246–e251. DOI: 10.1016/j.oooo.2014.09.032.
Grün P, Bandura P, Grün A, et al. Sensory disturbance along the inferior alveolar nerve as a first clinical sign of multiple florid cemento-osseous dysplasia of the mandible: a case report.Int J Surg Case Rep 2018;53:452–457. DOI: 10.1016/j.ijscr.2018.11.036.
Grewal HK, Goel P, Batra R, et al. A tender swelling of the left posterior mandible: an unusual case. J Oral Maxillofac Pathol 2014;18(2):332. DOI: 10.4103/0973-029X.140929.
Sarmento DJS, Carvalho SHG, JCWPA Filho, et al. Florid cemento-osseous dysplasia and peripheral giant cell granuloma in a patient with neurofibromatosis 1. An Bras Dermatol 2017;92:249–252. DOI: 10.1590/abd1806-4841.20175277
Sanjai K, Kumarswamy J, Kumar VK, et al. Florid cemento osseous dysplasia in association with dentigerous cyst. J Oral Maxillofac Pathol 2010;14(1):63–68. DOI: 10.4103/0973-029X.72503.
Schneider LC, Dolinsky HB, Grodjesk JE, et al. Malignant spindle cell tumor arising in the mandible of a patient with florid osseous dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88(1):69–73. DOI: 10.1016/s1079-2104(99)70195-2.
Cavalcante MB, de Oliveira Lima AL, Júnior MA, et al. Florid cemento-osseous dysplasia simultaneous the chronic suppurative osteomyelitis in mandible. J Craniofac Surg 2016;27(8):2173–2176. DOI: 10.1097/SCS.0000000000003095.
Singer SR, Mupparapu M, Rinaggio J. Florid cemento-osseous dysplasia and chronic diffuse osteomyelitis. Report of a simultaneous presentation and review of the literature. J Am Dent Assoc 2005;136(7): 927–931. DOI: 10.14219/jada.archive.2005.0294.
Lv M, You G, Wang J, et al. Identification of a novel ANO5 missense mutation in a Chinese family with familial florid osseous dysplasia. J Hum Genet 2019;64(7):599–607. DOI: 10.1038/s10038-019-0601-9.
Jin L, Liu Y, Sun F, et al. Three novel ANO5 missense mutations in Caucasian and Chinese families and sporadic cases with gnathodiaphyseal dysplasia. Sci Rep 2017;7:40935. DOI: 10.1038/srep40935.
Consolaro A, Paschoal SRB, Ponce JB, et al. Florid cemento-osseous dysplasia: a contraindication to orthodontic treatment in compromised areas. Dental Press J Orthod 2018;23(3)26–34. DOI: 10.1590/2177-6709.23.3.026-034.oin.
Minhas G, Hodge T, Gill DS. Orthodontic treatment and cemento-osseous dysplasia: a case report. J Orthod 2008;35(2):90–95. DOI: 10.1179/146531207225022500.
Sethusa MP, Khan MI. The orthodontic management of a patient presenting with cemento-osseous dysplasia. SADJ 2009;64(3):120–124. PMID: 19585913.
Kato CNAO, Sampaio JDA, Amaral TMP, et al. Oral management of a patient with cemento-osseous dysplasia: a case report. Rev Gaúch Odontol 2019;67:e20190012. DOI: 10.1590/1981-86 372019000123574.
Esfahanizadeh N, Yousefi H. Successful implant placement in a case of florid cemento-osseous dysplasia: a case report and literature review. J Oral Implantol 2018;44(4):275–279. DOI: 10.1563/aaid-joi-D-17-00140.
