Aim and objective: To determine and compare remineralizing efficacy of NovaMin, CPP-ACP, silver diamine fluoride (SDF), and P11-4. Materials and methods: Sixty permanent premolars were divided into four groups with 15 samples in each group; group I: self-assembling peptide (P11-4), group II: SDF, group III: Casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP), and group IV: NovaMin. Mineral content was assessed using a scanning electron microscope at 7, 14, and 21 days after remineralization with each agent. Results: The mean remineralization in group I at 7 days was 1.73 ± 0.02, at 14 days was 1.79 ± 0.01, and at 21 days was 1.90±0.03. Mean remineralization in group II was 1.61 ± 0.01, 1.64 ± 0.02, and 1.73 ± 0.03 at 7, 14, and 21 days, respectively. Mean remineralization in group III was 1.62 ± 0.01, 1.65 ± 0.02, and 1.74 ± 0.05 at 7, 14, and 21 days, respectively. Mean remineralization in group IV was 1.59 ± 0.02, 1.62 ± 0.07, and 1.70 ± 0.09 at 7, 14, and 21 days, respectively. The maximum value was obtained on day 21. There was a significant difference in mean remineralization values between group I vs group II, group I vs group III, and group I vs group IV (p < 0.05). Conclusion: Self-assembling peptides showed maximum remineralization in tested specimens followed by CPP-ACP, SDF, and NovaMin-containing toothpaste. Clinical significance: CPP-ACP, SDF, and NovaMin-containing toothpaste can be indicated for remineralization of initial caries in clinical use.
Gjorgievska ES, Nicholson JW. A preliminary study of enamel remineralization by dentifrices based on Recalden (CPP-ACP) and NovaMin (calcium-sodium-phosphosilicate). Acta Odontol Latinoam 2010;23(3):234–239.
Rose RK. Effects of an anticariogenic casein phosphopeptide on calcium diffusion in streptococcal model dental plaques. Arch Oral Biol 2000;45(7):569–575. DOI: 10.1016/s0003-9969(00)00017-0.
Kirkham J, Firth A, Vernals D, et al. Self-assembling peptide scaffolds promote enamel remineralization. J Dent Res 2007;86(5):426–430. DOI: 10.1177/154405910708600507.
Neel EAA, Aljabo A, Strange A, et al. Demineralization–remineralization dynamics in teeth and bone. Int J Nanomedicine 2016;11:4743–4763. DOI: 10.2147/IJN.S107624.
Vinod D, Gopalakrishnan A, Subramani SM, et al. A comparative evaluation of remineralizing potential of three commercially available remineralizing agents: an in vitro study. Int J Clin Pediatr Dent 2020 Jan–Feb;13(1):61–65. DOI: 10.5005/jp-journals-10005-1715.
La Torre G, Greenspan DC. The role of ionic release from NovaMin (calcium sodium phosphocilicate) in tubule occlusion: an exploratory in vitro study using radio-labeled isotopes. J Clin Dent 2010;21(3): 72–76.
Jayarajan J, Janardhanam P, Jayakumar P, et al. Efficacy of CPP-ACP and CPP-ACPF on enamel remineralization—an in vitro study using scanning electron microscope and DIAGNOdent. Indian J Dent Res 2011;22(1):77–82. DOI: 10.4103/0970-9290.80001.
Divyapriya GK, Yavagal PC, Veeresh DJ. Casein phosphopeptideamorphous calcium phosphate in dentistry: an update. Int J Oral Health Sci 2016;6(1):18–25. DOI: 10.4103/2231-6027.186660.
Rai R, Verma S, Bhardwaj A. NovaMin®: a promising antihypersensitivity agent. SPER J Pharm Res 2016;1(1):1–3.
Llodra JC, Rodriguez, Ferrer B, et al. Efficacy of silver diamine fluoride for caries reduction in primary teeth and first permanent molars of schoolchildren: 36-month clinical trial. J Dent Res 2005;84(8):721–724. DOI: 10.1177/154405910508400807.
Duangthip D, Fung MHT, Wong MCM, et al. Adverse effects of silver diamine fluoride treatment among preschool children. J Dent Res 2018;97(4):395–401. DOI: 10.1177/0022034517746678.
Welk A, Ratzmann A, Reich M, et al. Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions. Sci Rep Pub 2020;10(1):6819. DOI: 10.1038/s41598-020-63633-0.
Patil N, Choudhari S, Kulkarni S, et al. Comparative evaluation of remineralizing potential of three agents on artificially demineralized human enamel: an in vitro study. J Conserv Dent 2013;16(2):116–120. DOI: 10.4103/0972-0707.108185.
Gjorgievska E, Nicholson JW. Prevention of enamel demineralization after tooth bleaching by bioactive glass incorporated into toothpaste. Aust Dent J 2011;56(2):193–200. DOI: 10.1111/j.1834-7819.2011.01323.x.
Ogata K, Warita S, Shimazu K, et al. Combined effect of paste containing casein phosphopeptide-amorphous calcium phosphate and fluoride on enamel lesions: an in vitro pH-cycling study. Pediatr Dent 2010;32(5):433–438.
Sinha N, Gupta A, Logani A, et al. Remineralizing efficacy of silver diamine fluoride and glass ionomer type VII for their proposed use as indirect pulp capping materials–Part II (A clinical study). J Conserv Dent 2011;14(3):233–236. DOI: 10.4103/0972-0707.85796.
Manoharan V, Kumar RK, Sivanraj AK, et al. Comparative evaluation of remineralization potential of casein phosphopeptide-amorphous calcium fluoride phosphate and NovaMin on artificially demineralized human enamel: an in vitro study. Contemp Clin Dent 2018;9(Suppl 1):S58–S63. DOI: 10.4103/ccd.ccd_28_18.
Kamal D, Hassanein H, Elkassas D, et al. Comparative evaluation of remineralizing efficacy of biomimetic self-assembling peptide on artificially induced enamel lesions: an in vitro study. J Conserv Dent 2018 21(5):536–541. DOI: 10.4103/JCD.JCD_123_18.
Kumar K, Sreedharan S. Comparative evaluation of the remineralization potential of monofluorophosphate, casein phosphopeptideamorphous calcium phosphate and calcium sodium phosphosilicate on demineralized enamel lesions: an in vitro study. Cureus 2018; 27;10(7):e3059. DOI: 10.7759/cureus.3059.
Elsayad I, Sakr A, Badr Y. Combining casein phosphopeptideamorphous calcium phosphate with f luoride: synergistic remineralization potential of artificially demineralized enamel or not? J Biomed Opt 2009 Jul–Aug;14(4):044039. DOI: 10.1117/1.3210780.
de Oliveira PRA, Barboza CM, Barreto LSC, et al. Effect of CPP-ACP on remineralization of artificial caries-like lesion: an in situ study. Braz Oral Res 2020;34:e061. DOI: 10.1590/1807-3107bor-2020. vol34.0061.
Narayana SS, Deepa VK, Ahamed S, et al. Remineralization efficiency of bioactive glass on artificially induced carious lesion an in-vitro study. J Indian Soc Pedod Prev Dent [serial online] 2014 [cited 2020 Dec 27];32(1):19–25. DOI: 10.4103/0970-4388.127047.
Akyildiz M, Sonmez IS. Comparison of remineralising potential of nano silver fluoride, silver diamine fluoride and sodium fluoride varnish on artificial caries: an in vitro study. Oral Health Prev Dent 2019;17(5):469–477. DOI: 10.3290/j.ohpd.a42739.
Wierichs RJ, Stausberg S, Lausch J, et al. Caries-preventive effect of NaF, NaF plus TCP, NaF plus CPP-ACP, and SDF varnishes on sound dentin and artificial dentin caries in vitro. Caries Res 2018;52(3):199–211. DOI: 10.1159/000484483.
Sindhura V, Uloopi KS, Vinay C, et al. Evaluation of enamel remineralizing potential of self-assembling peptide P11-4 on artificially induced enamel lesions in vitro. J Indian Soc Pedod Prev Dent 2018;36(4):352–356. DOI: 10.4103/JISPPD.JISPPD_255_18.