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VOLUME 22 , ISSUE 6 ( June, 2021 ) > List of Articles

ORIGINAL RESEARCH

Assessment of Clinical and Radiographic Success Rate of Formocresol-based Pulpotomy versus Collagen-based Pulpotomy: An In Vivo Study

Vasanthakumari Anandan, Jaiganesh Inbanathan, Parthiban Saket, Vivek Krishnamoorthy, Shanmugavadivel Gandhi, Vignesh Krishnapillai Chandrababu

Keywords : Collagen-based pulpotomy, Formocresol-based pulpotomy

Citation Information : Anandan V, Inbanathan J, Saket P, Krishnamoorthy V, Gandhi S, Chandrababu VK. Assessment of Clinical and Radiographic Success Rate of Formocresol-based Pulpotomy versus Collagen-based Pulpotomy: An In Vivo Study. J Contemp Dent Pract 2021; 22 (6):680-685.

DOI: 10.5005/jp-journals-10024-3117

License: CC BY-NC 4.0

Published Online: 09-08-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim: The aim of the study is (a) To use collagen as a pulpotomy material in comparison with the gold standard formocresol-based pulpotomy, (b) to assess the clinical and radiographic success rate of formocresol pulpotomy and collagen-based pulpotomy, and (c) to compare the success rate of formocresol-based pulpotomy and collagen-based pulpotomy over a definitive interval of time. Materials and methods: Totally 30 primary first or second molars indicated for pulpotomy after confirming with the operative diagnosis were taken as samples for this study. This split-mouth technique consists of two groups: Group 1—formocresol pulpotomy (n = 15), and group 2—collagen-based pulpotomy (n = 15). Both the procedures were done in the same patient on regular appointments. Pre- and postoperative radiographs were taken. The children were recalled for clinical and radiographic follow-up at 2, 4, and 6 months. The success of the procedure was assessed based on clinical signs (pain, tenderness to percussion, abscess, swelling, fistula, and pathologic mobility) and radiographic findings (radicular radiolucency, internal and external root resorption, periodontal ligament (PDL) space widening, and furcation radiolucency). The Chi-square test was used to compare the differences between the groups. Result: The overall success rate for formocresol pulpotomy (n = 15) was 14, 13, and 10 for the second-, fourth-, and sixth-month review period, respectively. For collagen pulpotomy group (n = 15), the overall success rate was 14, 14, and 14 for the second-, fourth-, and sixth-month review period, respectively. The obtained data from the overall success rate were subjected to statistical analysis, and chi-square test was used. The p-value less than 0.1 was considered a statistically significant result. The chi-square value for the fourth- and sixth-month review was 0.37 and 3.33, respectively. Conclusion: Statistically significant value was obtained from the sixth-month review period (p <0.1), which describes that the overall success rate was better for the collagen pulpotomy group when compared with the formocresol pulpotomy group. Clinical significance: Collagen had proven to be a very good alternative for formocresol, its biocompatibility, and regenerative efficiency and is a benchmark for a better clinical success rate in dentistry. However, its implication in pulpotomy should be subjected to further comparative research study on mineral trioxide aggregate (MTA), Biodentine, etc.


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  1. Patino MG, Neiders ME, Andreana S, et al. Collagen as an implantable material in medicine and dentistry. J Oral Implantol 2002;28(5):220–225. DOI: 10.1563/1548-1336(2002)028<0220:CAAIMI>2.3.CO;2.
  2. Bunyaratavej P, Wang HL. Collagen Membrane a review. J Periodontol 2001;72:215-229. DOI:10.1902/jop.2001.72.2.215
  3. Rao KP. Recent developments of collagen-based materials for medical applications and drug delivery systems. J Biomater Sci Polym Ed 1995;7(7):623–645. DOI: 10.1163/156856295x00526.
  4. Burg KJL, Shalaby SW. Radiation sterilization of medical device sand pharmaceuticals. Irradiation of polymers. ACS Symp Ser 1996;620:240–245. DOI: 10.1021/bk-1996-0620.ch018.
  5. Hugar SM, Deshpande SD. Comparative investigation of clinical/radiographical signs of mineral trioxide aggregate and formocresol on pulpotomized primary molars. Contemp Clin Dent 2010;1(3):146–151. DOI: 10.4103/0976-237X.72779.
  6. Fuks AB. Pulp therapy for the primary dentition. In: Pinkham JR, Casamassimo PS, Fields HW Jr, et al., editors. Pediatric dentistry: infancy through adolescence. 5th ed. St. Louis, MO: Elsevier Saunders Co; 2013. p. 331–351.
  7. Juneja P, Kulkarni S. Clinical and radiographic comparison of biodentine, mineral trioxide aggregate and formocresol as pulpotomy agents in primary molars. Eur Arch Paediatr Dent 2017 Aug;18(4):271-278. DOI: 10.1007/s40368-017-0299-3
  8. Trairatvorakul C, Koothiratrakarn A. Calcium hydroxide partial pulpotomy is an alternative to formocresol pulpotomy based on a 3-year randomized trial. Int J Paediatr Dent 2012 Sep;22(5):382-389. DOI: 10.1111/j.1365-263X.2011.01211.x
  9. Hugar SM, Despande SD. Comparative investigation of clinical/radiographical signs of mineral trioxide aggregate and formocresol on pulpotomized primary molars. Contemp Clin Dent 2010 Jul;1(3):146-151. DOI: 10.4103/0976-237X.72779.
  10. Koubi G, Colon P, Franquin JC, et al. Clinical evaluation of the performance and safety of a new dentine substitute, Biodentine, in the restoration of posterior teeth – a prospective study. Clin Oral Investig 2013;17(1):243–249. DOI: 10.1007/s00784-012-0701-9.
  11. Laurent P, Camps J, About I. Biodentine (TM) induces TGF-β1 release from human pulp cells and early dental pulp mineralization. Int Endod J 2012;45(5):439–448. DOI: 10.1111/j.1365-2591.2011.01995.x.
  12. Airen P, Shigli A, Airen B. Comparative evaluation of formocresol and mineral trioxide aggregate in pulpotomized primary molars 2 year follow up. J Clin Pediatr Dent Winter 2012;37(2):143-7. DOI: 10.17796/jcpd.37.2.h427vr8157444462
  13. Olczak-Kowalczyk D. et al. Ferric Sulfate and Formocresol pulpotomies in paediatric dental practice. A prospective retrospective study. Eur J Paediatr Dent. 2019 Mar;20(1):27-32. DOI: 10.23804/ejpd.2019.20.01.06
  14. Hume WR. The pharmacologic and toxicological properties of zinc oxide-eugenol. J Am Dent Assoc 1986;113(5):789–791. DOI: 10.14219/jada.archive.1986.0256.
  15. Chakraborty A, Dey B, Jana S. A nonconventional approach to formocresol pulpotomy. Int J Clin Pediatr Dent 2018;11(6):490–495. DOI: 10.5005/jp-journals-10005-1563.
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