The Journal of Contemporary Dental Practice

Register      Login



Volume / Issue

Online First

Related articles

VOLUME 23 , ISSUE 10 ( October, 2022 ) > List of Articles


Efficacy of GLUMA for the Treatment of Dentin Hypersensitivity Compared to Lasers: A Systematic Review

Nassreen H Albar

Keywords : Dentin hypersensitivity, Desensitization, GLUMA, Low-level laser, Glutaraldehyde, Pain relief

Citation Information : Albar NH. Efficacy of GLUMA for the Treatment of Dentin Hypersensitivity Compared to Lasers: A Systematic Review. J Contemp Dent Pract 2022; 23 (10):1057-1065.

DOI: 10.5005/jp-journals-10024-3420

License: CC BY-NC 4.0

Published Online: 07-03-2023

Copyright Statement:  Copyright © 2022; The Author(s).


Objective: Dentin hypersensitivity (DH) is characterized by a short, sharp pain in response to a thermal or tactile stimulus. The application of desensitizing agents such as GLUMA and laser is a non-invasive and safe approach to decrease sensitivity. The evidence for the efficacy of GLUMA desensitizer compared to laser desensitization in patients with DH was evaluated for 6 months. Design: In March 2022, an electronic search of PubMed, Scopus, and Web of Science databases was conducted. Articles published in English that compared GLUMA and laser in the treatment of DH with a follow-up of 6 months or more were included. Randomized, non-randomized controlled trials, and clinical trials were included. Risk of bias assessment tools developed by the Cochrane collaboration ROB 2 and ROBINS-I were used to assess the quality of studies. The GRADE assessment method was used to assess the certainty of evidence. Results: About 36 studies were identified in the search results. After applying the predefined eligibility criteria, eight studies with 205 participants and 894 sites were included in this review. Of the eight studies, four were judged to be at high risk of bias, three had some concerns, and one had a serious risk of bias. The certainty of the evidence was graded as low. Conclusion: Based on limited evidence, GLUMA and laser appear to be equally effective in providing relief from DH. GLUMA showed an immediate effect and provided pain relief. Over the course of a week, laser showed long-term stable results. GLUMA is effective in providing immediate relief.

  1. Canadian Advisory Board on Dentin Hypersensitivity. Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. J Can Dent Assoc 2003;69(4):221–226. PMID: 12662460.
  2. Splieth CH, Tachou A. Epidemiology of dentin hypersensitivity. Clin Oral Investig 2013;17(1):3–8. DOI: 10.1007/s00784-012-0889-8.
  3. Cunha-Cruz J, Wataha JC. The burden of dentine hypersensitivity. In Dentine hypersensitivity 2015 (pp. 33–44). Elsevier.
  4. Graham FL, Tatton-Brown C, Meert G, et al. Prevalence and severity of dentin hypersensitivity: a global perspective. J Dent Res 2003; 82:(B134).
  5. Gillam DG. Current diagnosis of dentin hypersensitivity in the dental office: An overview. Clin Oral Investig 2013;17(S1):21–29. DOI: 10.1007/s00784-012-0911-1.
  6. Litonjua LA, Andreana S, Bush PJ, et al. Toothbrushing and gingival recession. Int Dent J 2003;53(2):67–72. DOI: 10.1111/j.1875-595X.2003.tb00661.x.
  7. Wichgers TG, Emert RL. Dentin hypersensitivity. Oral Health 1997;87(3):51–53, 55–56, 59; quiz 61. PMID: 9462135.
  8. Addy M. Dentine hypersensitivity: new perspectives on an old problem. Int Dent J 2002;52(5):367–375. DOI: 10.1002/j.1875-595X.2002.tb00936.x.
  9. Bamise CT, Olusile AO, Oginni AO. An analysis of the etiological and predisposing factors related to dentin hypersensitivity. J Contemp Dent Pract 2008;9(5):52–59. PMID: 18633469.
  10. Goh V, Corbet EF, Leung WK. Impact of dentine hypersensitivity on oral health-related quality of life in individuals receiving supportive periodontal care. J Clin Periodont 2016;43(7):595–602. DOI: 10.1111/jcpe.12552.
  11. Lima TC, Vieira-Barbosa NM, Grasielle de Sá Azevedo C, et al. Oral health-related quality of life before and after treatment of dentin hypersensitivity with cyanoacrylate and laser. J Periodont 2017;88(2):166–172. DOI: 10.1902/jop.2016.160216.
  12. Breivik H, Collett B, Ventafridda V, et al. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 2006;10(4):287–287. DOI: 10.1016/j.ejpain.2005.06.009.
  13. Schmidlin PR, Sahrmann P. Current management of dentin hypersensitivity. Clin Oral Investig 2013;17(S1):55–59. DOI: 10.1007/s00784-012-0912-0.
  14. Samuel SR, Khatri SG, Acharya S, et al. Evaluation of instant desensitization after a single topical application over 30 days: a randomized trial. Aust Dent J 2015;60(3):336–342. DOI: 10.1111/adj.12341.
  15. Arrais CAG, Chan DCN, Giannini M. Effects of desensitizing agents on dentinal tubule occlusion. J Appl Oral Sci 2004;12:144–148. DOI: 10.1590/s1678-77572004000200012.
  16. Dondi dall'Orologio G, Lone A, Finger WJ. Clinical evaluation of the role of glutardialdehyde in a one-bottle adhesive. Am J Dent 2002;15(5):330–334. PMID: 12537345.
  17. Patil S, Naik B, Suma R. Evaluation of three different agents for in-office treatment of dentinal hypersensitivity: a controlled clinical study. Ind J Dental Res 2015;26(1):38. DOI: 10.4103/0970-9290.156796.
  18. Vora J, Mehta D, Meena N, et al. Effects of two topical desensitizing agents and placebo on dentin hypersensitivity. Am J Dent 2012;25(5):293–298. PMID: 23243978.
  19. Orchardson R, Collins WJ. Clinical features of hypersensitive teeth. Br Dent J 1987;162(7):253–256. DOI: 10.1038/sj.bdj.4806096.
  20. Rosaiah K, Aruna K. Clinical efficacy of amorphous calcium phosphate, G.C. tooth mousse and Gluma desensitizer in treating dentin hypersensitivity. Int J Dent Clin 2011;3(1):1–4. ISSN 0975-8437.
  21. Lee SY, Jung HI, Jung BY, et al. Desensitizing efficacy of nano-carbonate apatite dentifrice and Er,Cr:YSGG laser: a randomized clinical trial. Photomed Laser Surg 2015;33(1):9–14. DOI: 10.1089/pho.2014.3787.
  22. Pourshahidi S, Ebrahimi H, Mansourian A, et al. Comparison of Er,Cr:YSGG and diode laser effects on dentin hypersensitivity: A split-mouth randomized clinical trial. Clin Oral Investig 2019;23(11): 4051–4058. DOI: 10.1007/s00784-019-02841-z.
  23. Gerschman JA, Ruben J, Gebart-Eaglemont J. Low level laser therapy for dentinal tooth hypersensitivity. Aust Dent J 1994;39(6):353–357. DOI: 10.1111/j.1834-7819.1994.tb03105.x.
  24. Orchardson Robert, Peacock JM, John Whitters C. Effect of pulsed Nd:YAG laser radiation on action potential conduction in isolated mammalian spinal nerves. Lasers Surg Med 1997;21(2):142–148. DOI: 10.1002/(SICI)1096-9101(1997)21:2<142::AID-LSM5>3.0.CO;2-Q.
  25. Asnaashari M, Moeini M. Effectiveness of lasers in the treatment of dentin hypersensitivity. J Lasers Med Sci 2013;4(1):1–7. PMID: 25606300.
  26. Corona SAM, Nascimento TN do, Catirse ABE, et al. Clinical evaluation of low-level laser therapy and fluoride varnish for treating cervical dentinal hypersensitivity. J Oral Rehabil 2003;30(12):1183–1189. DOI: 10.1111/j.1365-2842.2003.01185.x.
  27. Zhang C, Matsumoto K, Kimura Y, et al. Effects of CO2 laser in treatment of cervical dentinal hypersensitivity. J Endod 1998;24(9):595–597. DOI: 10.1016/S0099-2399(98)80117-9.
  28. Sgolastra Fabrizio, Petrucci A, Gatto R, et al. Effectiveness of laser in dentinal hypersensitivity treatment: a systematic review. J Endod 2011;37(3):297–303. DOI: 10.1016/j.joen.2010.11.034.
  29. Mahdian M, Behboodi S, Ogata Y, et al. Laser therapy for dentinal hypersensitivity. Cochrane Database Syst Rev 2021;13:(7)CD009434. DOI: 10.1002/14651858.
  30. Rezazadeh F, Dehghanian P, Jafarpour, D. Laser effects on the prevention and treatment of dentinal hypersensitivity: a systematic review. J Lasers Med Sci 2018;10(1):1–11. DOI: 10.15171/jlms.2019.01.
  31. Page MJ, McKenzie JE, Bossuyt PM, et al. Updating guidance for reporting systematic reviews: development of the PRISMA 2020 statement. J Clin Epidemiol 2021;134:103–112. DOI: 10.1016/j.jclinepi.2021.02.003.
  32. Higgins JPT, Thomas J, Chandler J et al. Cochrane handbook for systematic reviews of interventions. Cochrane Handb Syst Rev Interv [Internet] 2019;1(1):1–694. Available from:
  33. Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019;28(7)14898. DOI: 10.1136/bmj.l4898. DOI: 10.1136/bmj.l4898.
  34. Sterne JA, Hernán MA, Reeves BC, et al. ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions. BMJ 2016;355 (12):i4919. DOI: 10.1136/bmj.i4919.
  35. Schünemann HJ, Cuello C, Akl EA, et al. GRADE guidelines: 18. How ROBINS-I and other tools to assess risk of bias in nonrandomized studies should be used to rate the certainty of a body of evidence. J Clin Epidemiol 2019;111:105–114. DOI: 10.1016/j.jclinepi.2018.01.012.
  36. Aranha ACC, Pimenta LAF, Marchi GM. Clinical evaluation of desensitizing treatments for cervical dentin hypersensitivity. Braz Oral Res 2009;23(3):333–339. DOI: 10.1590/s1806-83242009000300018.
  37. Ehlers V, Ernst C-P, Reich M, et al. Clinical comparison of gluma and Er:YAG laser treatment of cervically exposed hypersensitive dentin. Am J Dent 2012;25(3):131–135. PMID: 22988681.
  38. Femiano F, Femiano R, Lanza A, et al. Efficacy of diode laser in association to sodium fluoride vs Gluma desensitizer on treatment of cervical dentin hypersensitivity. A double blind controlled trial. Am J Dent 2013;26(4):214–218. PMID: 24693632.
  39. Kara HB, Cakan U, Yilmaz B, et al. Efficacy of diode laser and Gluma on post-preparation sensitivity: a randomized split-mouth clinical study. J Esthet Restor Dent 2016;28(6):405–411. DOI: 10.1111/jerd.12230.
  40. Lopes AO, de Paula Eduardo C, Aranha ACC. Clinical evaluation of low-power laser and a desensitizing agent on dentin hypersensitivity. Lasers Med Sci 2015;30(2):823–829. DOI: 10.1007/s10103-013-1441-z.
  41. Lopes AO, de Paula Eduardo C, Aranha ACC. Evaluation of different treatment protocols for dentin hypersensitivity: an 18-month randomized clinical trial. Lasers Med Sci 2017;32(5):1023–1030. DOI: 10.1007/s10103-017-2203-0.
  42. Lopes AO, Aranha ACC. Comparative evaluation of the effects of Nd:YAG laser and a desensitizer agent on the treatment of dentin hypersensitivity: a clinical study. Photomed Laser Surg 2013;31(3): 132–138. DOI: 10.1089/pho.2012.3386.
  43. Ozlem K, Esad GM, Ayse A, et al. Efficiency of lasers and a desensitizer agent on dentin hypersensitivity treatment: a clinical study. Niger J Clin Pract 2018;21(2):225–230. DOI: 10.4103/njcp.njcp_411_16.
  44. McGuinness LA, Higgins JPT. Risk-of-bias VISualization (robvis): An R package and shiny web app for visualizing risk-of-bias assessments. Res Synth Methods 2021;12(1):55–61. DOI: 10.1002/jrsm.1411.
  45. Bartold PM. Dentinal hypersensitivity: a review. Aust Dent J 2006;51(3):212–218; quiz 276. PMID: 17037886.
  46. da Rosa WL de O, Lund RG, Piva E, et al. The effectiveness of current dentin desensitizing agents used to treat dental hypersensitivity: a systematic review. Quintessence Int 2013;44(7):535–546. DOI: 10.3290/j.qi.a29610.
  47. Sgolastra F, Petrucci A, Severino M, et al. Lasers for the treatment of dentin hypersensitivity. J Dent Res 2013;92(6):492–499. DOI: 10.1177/0022034513487212.
  48. Holland GR, Narhi MN, Addy M. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. J Clin Periodontol 1997;24(11):808–813. DOI: 10.1111/j.1600-051x.1997.tb01194.x.
  49. Schweikl H, Schmalz G. Glutaraldehyde-containing dentin bonding agents are mutagens in mammalian cells in vitro. J Biomed Mater Res 1997;36(3):284–288. DOI: 10.1002/(SICI)1097-4636(19970905)36:3<284::AID-JBM2>3.0.CO;2-A.
  50. Scheffel DLS, Soares DG, Basso FG, et al. Transdentinal cytotoxicity of glutaraldehyde on odontoblast-like cells. J Dent 2015;43(8):997–1006. DOI: 10.1016/j.jdent.2015.05.004.
  51. Meryon SD, Brook AM. In vitro cytotoxicity of three dentine bonding agents. J Dent 1989;17(6):279–283. DOI: 10.1016/0300-5712(89) 90035-3.
  52. Schünemann H, Brożek J, Guyatt G, et al. Grade handbook for grading quality of evidence and strength of recommendations. The GRADE Working Group 2013.
  53. He S, Wang Y, Li X, et al. Effectiveness of laser therapy and topical desensitising agents in treating dentine hypersensitivity: a systematic review. J Oral Rehabil 2011;38(5):348–358. DOI: 10.1111/j.1365-2842.2010.02193.x.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.