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VOLUME 23 , ISSUE 4 ( April, 2022 ) > List of Articles

ORIGINAL RESEARCH

Assessing the In Vitro Antioxidant and Anti-inflammatory Activity of Moringa oleifera Crude Extract

Shanmugapriya Ramamurthy, Kavitha Thiagarajan, Sheeja Varghese, B Prem Karthick

Keywords : Anti-inflammatory, Antioxidant, Moringa oleifera, Periodonatal disease

Citation Information : Ramamurthy S, Thiagarajan K, Varghese S, Karthick BP. Assessing the In Vitro Antioxidant and Anti-inflammatory Activity of Moringa oleifera Crude Extract. J Contemp Dent Pract 2022; 23 (4):437-442.

DOI: 10.5005/jp-journals-10024-3323

License: CC BY-NC 4.0

Published Online: 11-07-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Background: Chronic inflammation and oxidative stress play a vital role in the pathogenesis of various diseases of the oral cavity including periodontal disease. Phytochemicals present in plants with antioxidant (AO) and anti-inflammatory properties could aid as a therapeutic adjunct in the management of these diseases. Aim: To assess the antioxidant and anti-inflammatory effects of aqueous and ethanolic extracts of Moringa oleifera Lam. (MOL) in an in vitro environment. Materials and methods: Aqueous and ethanolic extracts of M. oleifera Lam. were prepared by maceration. Antioxidant activity was assessed by FRAP, hydroxyl radical scavenging activity, and DPPH radical scavenging assay. Anti-inflammatory activity was assessed by Albumin Denaturation Assay. Experiments were repeated thrice, and mean and standard deviation were calculated. Results: Both the test substances exhibited significant antioxidant and anti-inflammatory activity, and aqueous extracts exhibited higher activity than ethanolic extract. Summary and conclusion: The anti-inflammatory and antioxidant activity of M. oleifera Lam. could be further explored for the management of periodontal disease as a local drug delivery system with the extract could be developed.

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