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VOLUME 23 , ISSUE 7 ( July, 2022 ) > List of Articles


Monocyte-to-High-density Lipoprotein Cholesterol Ratio as a Novel Inflammatory Marker in Periodontal Disease: A Pilot Study

TA Lalitha, Archana Balakrishnan, S Parthiban, R Kadhiresan, T Sivasankari

Keywords : Biomarker, High-density lipoprotein cholesterol, Inflammation, Malondialdehyde, Monocytes, Periodontitis

Citation Information : Lalitha T, Balakrishnan A, Parthiban S, Kadhiresan R, Sivasankari T. Monocyte-to-High-density Lipoprotein Cholesterol Ratio as a Novel Inflammatory Marker in Periodontal Disease: A Pilot Study. J Contemp Dent Pract 2022; 23 (7):709-712.

DOI: 10.5005/jp-journals-10024-3359

License: CC BY-NC 4.0

Published Online: 10-11-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Aim: The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has currently been proposed as an indicator of inflammation. The aim of the present study was to assess the relationship between the monocyte-to-high-density lipoprotein cholesterol ratio and periodontal health and disease. Materials and methods: A total of 90 patients were selected for the study – 30 healthy patients (group I) and 60 periodontitis patients (groups II and III). All the patients were subjected to blood sampling and serum malondialdehyde (MDA), high-density lipoprotein cholesterol (HDL) levels and monocyte counts were estimated. Results: Monocyte-to-high-density lipoprotein cholesterol ratio was 80.64 ± 28.71 for patients with moderate periodontitis (group II), 95.14 ± 53.21 in severe periodontitis (group III), and 14.28 ± 16.05 for the healthy patients. Monocyte-to-high-density lipoprotein cholesterol ratio values were found to be statistically significantly higher than the control group (p < 0.001). Monocyte-to-high-density lipoprotein cholesterol ratio also showed significantly positive correlation with the severity of periodontitis. Conclusion: Malondialdehyde and MHR are increased in periodontal disease and correlate with severity of the periodontal disease. Clinical significance: Monocyte-to-high-density lipoprotein cholesterol ratio is a novel, readily available inflammatory and oxidative stress marker in patients with periodontitis and can be useful to evaluate periodontitis and disease severity.

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