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VOLUME 24 , ISSUE 1 ( January, 2023 ) > List of Articles


Can Nasal Irrigation Serve as a Complementary Strategy for Preventing COVID-associated Mucormycosis?

Prashanth Panta, Archana Andhavarapu

Keywords : COVID-19, Mucormycosis, Nasal irrigation, Saline use, Severe acute respiratory syndrome coronavirus 2

Citation Information : Panta P, Andhavarapu A. Can Nasal Irrigation Serve as a Complementary Strategy for Preventing COVID-associated Mucormycosis?. J Contemp Dent Pract 2023; 24 (1):1-3.

DOI: 10.5005/jp-journals-10024-3477

License: CC BY-NC 4.0

Published Online: 04-05-2023

Copyright Statement:  Copyright © 2023; The Author(s).


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  1. Patel A, Kaur H, Xess I, et al. A multicentre observational study on the epidemiology, risk factors, management and outcomes of mucormycosis in India. Clin Microbiol Infect 2020;26(7):944.e9–944.e15. DOI: 10.1016/j.cmi.2019.11.021.
  2. John TM, Jacob CN, Kontoyiannis DP. When uncontrolled diabetes mellitus and severe COVID-19 converge: The perfect storm for mucormycosis. J Fungi (Basel) 2021;7(4):298. DOI: 10.3390/jof7040298.
  3. Moorthy A, Gaikwad R, Krishna S, et al. SARS-CoV-2, uncontrolled diabetes and corticosteroids – An unholy trinity in invasive fungal infections of the maxillofacial region? A retrospective, multi-centric analysis. J Maxillofac Oral Surg 2021;20(3):418–425. DOI: 10.1007/s12663-021-01532-1.
  4. Prakash H, Chakrabarti A. Epidemiology of mucormycosis in India. Microorganisms 2021;9(3):523. DOI: 10.3390/microorganisms9030523.
  5. Alba-Loureiro TC, Munhoz CD, Martins JO, et al. Neutrophil function and metabolism in individuals with diabetes mellitus. Braz J Med Biol Res 2007;40(8):1037–1044. DOI: 10.1590/S0100-879X2006005000143.
  6. Panta P, Stone N. COVID-associated mucormycosis (CAM) in India is a multidimensional problem. Br J Oral Maxillofac Surg 2021; 59(10):1332–1333. DOI: 10.1016/j.bjoms.2021.08.008.
  7. Panta P. Additional insights on COVID-associated mucormycosis. Br J Oral Maxillofac Surg 2022;60(4):e531–e532. DOI: 10.1016/j.bjoms.2021.09.020
  8. Patel A, Agarwal R, Rudramurthy SM, et al. Multicenter epidemiologic study of coronavirus disease-associated mucormycosis, India. Emerg Infect Dis 2021;27(9):2349–2359. DOI: 10.3201/eid2709.210934.
  9. Sen M, Honavar SG, Bansal R, et al. Epidemiology, clinical profile, management, and outcome of COVID-19-associated rhino-orbital-cerebral mucormycosis in 2826 patients in India – Collaborative OPAI-IJO Study on Mucormycosis in COVID-19 (COSMIC), Report 1. Indian J Ophthalmol 2021;69(7):1670–1692. DOI: 10.4103/ijo.IJO_1565_21.
  10. Panta P, Chatti K, Andhavarapu A. Do saline water gargling and nasal irrigation confer protection against COVID-19? Explore (NY) 2021;17(2):127–129. DOI: 10.1016/j.explore.2020.09.010.
  11. Panta P, Baruah B, Patil S. Hypertonic saline use and traditional nasal irrigation: A possible preventative measure against COVID-19. J Contemp Dent Pract 2022;23(4):379–382. PMID: 35945828.
  12. Kimura KS, Freeman MH, Wessinger BC, et al. Interim analysis of an open-label randomized controlled trial evaluating nasal irrigations in non-hospitalized patients with coronavirus disease 2019. Int Forum Allergy Rhinol 2020;10(12):1325–1328. DOI: 10.1002/alr.22703.
  13. Rastogi S, Verma A. Jalaneti (saline nasal irrigation) as primary intervention in suspected rhino-orbito-cerebral mucormycosis helps improving the recovery: A case report. J Ayurveda Integr Med 2021;13(2):100516. DOI: 10.1016/j.jaim.2021.08.009.
  14. Letscher-Bru V, Obszynski CM, Samsoen M, et al. Antifungal activity of sodium bicarbonate against fungal agents causing superficial infections. Mycopathologia 2013;175(1–2):153–158. DOI: 10.1007/s11046-012-9583-2.
  15. Ibrahim AS, Spellberg B, Edwards J, Jr. Iron acquisition: A novel perspective on mucormycosis pathogenesis and treatment. Curr Opin Infect Dis 2008;21(6):620–625. DOI: 10.1097/QCO.0b013e3283165fd1.
  16. Kim HJ, Lee JG, Kang JW, et al. Effects of a low concentration hypochlorous acid nasal irrigation solution on bacteria, fungi, and virus. Laryngoscope 2008;118(10):1862–1867. DOI: 10.1097/MLG.0b013e31817f4d34.
  17. Ramalingam S, Cai B, Wong J, et al. Antiviral innate immune response in non-myeloid cells is augmented by chloride ions via an increase in intracellular hypochlorous acid levels. Sci Rep 2018;8(1):13630. DOI: 10.1038/s41598-018-31936-y.
  18. Zmuda HM, Mohamed A, Raval YS, et al. Hypochlorous acid-generating electrochemical scaffold eliminates Candida albicans biofilms. J Appl Microbiol 2020;129(4):776–786. DOI: 10.1111/jam.14656.
  19. Kim HC, Kim DK, Kim JS, et al. Hypochlorous acid versus saline nasal irrigation in allergic rhinitis: A multicenter, randomized, double-blind, placebo-controlled study. Am J Rhinol Allergy 2022;36(1):129–134. DOI:10.1177/19458924211029428.
  20. Shirazi MA, Stankiewicz JA, Kammeyer P. Activity of nasal amphotericin B irrigation against fungal organisms in vitro. Am J Rhinol 2007;21(2):145–148. DOI: 10.2500/ajr.2007.21.2988.
  21. Khafagy R, Gupta S, Campisi P, et al. Treatment of localized mucormycosis using nasal amphotericin B irrigation in pediatric oncology. Pediatr Blood Cancer 2020;67(4):e28175. DOI: 10.1002/pbc.28175.
  22. Jiang R-S, Hsu S-H, Liang K-L. Amphotericin B nasal irrigation as an adjuvant therapy after functional endoscopic sinus surgery. Am J Rhinol Allergy 2015;29(6):435–440. DOI: 10.2500/ajra.2015.29.4246.
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